Prenatal GABAB Receptor Agonist Administration Corrects the Inheritance of Autism-Like Core Behaviors in Offspring of Mice Prenatally Exposed to Valproic Acid

Prenatal GABAB Receptor Agonist Administration Corrects the Inheritance of Autism-Like Core Behaviors in Offspring of Mice Prenatally Exposed to Valproic Acid

This study was performed to evaluate the effects of prenatal baclofen (a GABAB receptor agonist) treatment on the inheritance of autism-like behaviors in valproic acid (VPA)-exposed mice. VPA model mice (first generation, F1) that were prenatally exposed to VPA exhibited robust core autism-like beha...

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Bibliographic Details
Main Authors: Shucai Jiang, Maotao He, Lifei Xiao, Yu Sun, Jiangwei Ding, Wenchao Li, Baorui Guo, Lei Wang, Yangyang Wang, Caibin Gao, Tao Sun, Feng Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Psychiatry
Subjects:
autism spectrum disorder (ASD)
valproic acid (VPA)
baclofen
GABAB
inheritance
mice
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2022.835993/full

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