The effect of vaginal cream containing herbal extracts (Foeniculum vulgare, Salvia officinalis and Flaxseed) on the mental symptoms of vaginal atrophy in postmenopausal women: A randomized controlled clinical trial
Introduction: Most menopausal women experience changes due to decreased estrogen secretion. Vaginal atrophy is one of the most common changes during menopause. This study was performed with aim to determine the effect of vaginal cream containing herbal extract (Foeniculum vulgare, Salvia officinalis...
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| Format: | Article |
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Mashhad University of Medical Sciences
2021-12-01
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| Series: | Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān |
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| Online Access: | https://ijogi.mums.ac.ir/article_19540_95fde52b98d9858e87d2fa6f4f2da0d2.pdf |
| _version_ | 1797984719356297216 |
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| author | Golshan Tahmasebi Sharareh Jannesari Foroogh Namjooyan Malihe Nasiri Aryan Sadeghyan |
| author_facet | Golshan Tahmasebi Sharareh Jannesari Foroogh Namjooyan Malihe Nasiri Aryan Sadeghyan |
| author_sort | Golshan Tahmasebi |
| collection | DOAJ |
| description | Introduction: Most menopausal women experience changes due to decreased estrogen secretion. Vaginal atrophy is one of the most common changes during menopause. This study was performed with aim to determine the effect of vaginal cream containing herbal extract (Foeniculum vulgare, Salvia officinalis and Flaxseed) on mental symptoms of vaginal atrophy in postmenopausal women.
Methods: The triple-blind clinical trial study was performed in 2019 on 60 postmenopausal women with symptoms of vaginal atrophy referred to the selected health centers in Ahvaz, Iran. The subjects were randomly divided into two groups of 30 women to receive vaginal cream containing herbal extract (Foeniculum vulgare, Salvia officinalis and Flaxseed) and placebo for eight weeks. Mental symptoms of vaginal atrophy including dryness, burning and itching, vaginal pain and pain during intercourse were assessed using the most bothersome symptom (MBS) checklist before the intervention and two, four and eight weeks after the treatment. Data were analyzed by SPSS software (version 22) and Mann-Whitney, Friedman and independent t-test. P<0.05 was considered statistically significant.
Results: After treatment with the vaginal cream containing herbal extracts (Foeniculum vulgare, Salvia officinalis and Flaxseed) in the intervention group, the mental symptoms of vaginal atrophy significantly reduced compared to the beginning of the study (P<0.001). The vaginal cream containing herbal extracts (Foeniculum vulgare, Salvia officinalis and Flaxseed) compared to placebo cream significantly reduced the mental symptoms of vaginal atrophy in postmenopausal women after two weeks (P=0.046), four weeks (P<0.000) and eight weeks (P<0.000).
Conclusion: The use of vaginal cream containing herbal extracts (Foeniculum vulgare, Salvia officinalis and Flaxseed) compared with placebo cream reduces the symptoms of vaginal atrophy in postmenopausal women. Therefore, this cream is recommended for women with vaginal atrophy. |
| first_indexed | 2024-04-11T07:07:18Z |
| format | Article |
| id | doaj.art-e313fcbcf5a04109b7fbfc375dd713f9 |
| institution | Directory Open Access Journal |
| issn | 1680-2993 2008-2363 |
| language | fas |
| last_indexed | 2024-04-11T07:07:18Z |
| publishDate | 2021-12-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān |
| spelling | doaj.art-e313fcbcf5a04109b7fbfc375dd713f92022-12-22T04:38:22ZfasMashhad University of Medical SciencesMajallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān1680-29932008-23632021-12-012411596910.22038/ijogi.2021.1954019540The effect of vaginal cream containing herbal extracts (Foeniculum vulgare, Salvia officinalis and Flaxseed) on the mental symptoms of vaginal atrophy in postmenopausal women: A randomized controlled clinical trialGolshan Tahmasebi0Sharareh Jannesari1Foroogh Namjooyan2Malihe Nasiri3Aryan Sadeghyan4M.Sc. in Midwifery, Student Research Committee, School of Nursing & Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Instructor, Department of Midwifery and Reproductive Health, Midwifery and Reproductive Health Research Center, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Assistant professor, Department of Pharmacongnosy, Research Center for Traditional Medicine and History of Medicine, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.Assistant professor, Department of Biostatistics, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.Student of Electrical engineering, Student Research Committee, School of Electrical and Computer Engineering, Semnan University, Semnan, Iran.Introduction: Most menopausal women experience changes due to decreased estrogen secretion. Vaginal atrophy is one of the most common changes during menopause. This study was performed with aim to determine the effect of vaginal cream containing herbal extract (Foeniculum vulgare, Salvia officinalis and Flaxseed) on mental symptoms of vaginal atrophy in postmenopausal women. Methods: The triple-blind clinical trial study was performed in 2019 on 60 postmenopausal women with symptoms of vaginal atrophy referred to the selected health centers in Ahvaz, Iran. The subjects were randomly divided into two groups of 30 women to receive vaginal cream containing herbal extract (Foeniculum vulgare, Salvia officinalis and Flaxseed) and placebo for eight weeks. Mental symptoms of vaginal atrophy including dryness, burning and itching, vaginal pain and pain during intercourse were assessed using the most bothersome symptom (MBS) checklist before the intervention and two, four and eight weeks after the treatment. Data were analyzed by SPSS software (version 22) and Mann-Whitney, Friedman and independent t-test. P<0.05 was considered statistically significant. Results: After treatment with the vaginal cream containing herbal extracts (Foeniculum vulgare, Salvia officinalis and Flaxseed) in the intervention group, the mental symptoms of vaginal atrophy significantly reduced compared to the beginning of the study (P<0.001). The vaginal cream containing herbal extracts (Foeniculum vulgare, Salvia officinalis and Flaxseed) compared to placebo cream significantly reduced the mental symptoms of vaginal atrophy in postmenopausal women after two weeks (P=0.046), four weeks (P<0.000) and eight weeks (P<0.000). Conclusion: The use of vaginal cream containing herbal extracts (Foeniculum vulgare, Salvia officinalis and Flaxseed) compared with placebo cream reduces the symptoms of vaginal atrophy in postmenopausal women. Therefore, this cream is recommended for women with vaginal atrophy.https://ijogi.mums.ac.ir/article_19540_95fde52b98d9858e87d2fa6f4f2da0d2.pdfflaxseedfoeniculum vulgaremenopausephytoestrogensalvia officinalis |
| spellingShingle | Golshan Tahmasebi Sharareh Jannesari Foroogh Namjooyan Malihe Nasiri Aryan Sadeghyan The effect of vaginal cream containing herbal extracts (Foeniculum vulgare, Salvia officinalis and Flaxseed) on the mental symptoms of vaginal atrophy in postmenopausal women: A randomized controlled clinical trial Majallah-i Zanān, Māmā̓ī va Nāzā̓ī-i Īrān flaxseed foeniculum vulgare menopause phytoestrogen salvia officinalis |
| title | The effect of vaginal cream containing herbal extracts (Foeniculum vulgare, Salvia officinalis and Flaxseed) on the mental symptoms of vaginal atrophy in postmenopausal women: A randomized controlled clinical trial |
| title_full | The effect of vaginal cream containing herbal extracts (Foeniculum vulgare, Salvia officinalis and Flaxseed) on the mental symptoms of vaginal atrophy in postmenopausal women: A randomized controlled clinical trial |
| title_fullStr | The effect of vaginal cream containing herbal extracts (Foeniculum vulgare, Salvia officinalis and Flaxseed) on the mental symptoms of vaginal atrophy in postmenopausal women: A randomized controlled clinical trial |
| title_full_unstemmed | The effect of vaginal cream containing herbal extracts (Foeniculum vulgare, Salvia officinalis and Flaxseed) on the mental symptoms of vaginal atrophy in postmenopausal women: A randomized controlled clinical trial |
| title_short | The effect of vaginal cream containing herbal extracts (Foeniculum vulgare, Salvia officinalis and Flaxseed) on the mental symptoms of vaginal atrophy in postmenopausal women: A randomized controlled clinical trial |
| title_sort | effect of vaginal cream containing herbal extracts foeniculum vulgare salvia officinalis and flaxseed on the mental symptoms of vaginal atrophy in postmenopausal women a randomized controlled clinical trial |
| topic | flaxseed foeniculum vulgare menopause phytoestrogen salvia officinalis |
| url | https://ijogi.mums.ac.ir/article_19540_95fde52b98d9858e87d2fa6f4f2da0d2.pdf |
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