Exercise, mitochondrial dysfunction and inflammasomes in skeletal muscle
In the broad field of inflammation, skeletal muscle is a tissue that is understudied. Yet it represents about 40% of body mass in non-obese individuals and is therefore of fundamental importance for whole body metabolism and health. This article provides an overview of the unique features of skeleta...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Biomedical Journal |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2319417023000732 |
| _version_ | 1797242985411248128 |
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| author | Mikhaela B. Slavin Priyanka Khemraj David A. Hood |
| author_facet | Mikhaela B. Slavin Priyanka Khemraj David A. Hood |
| author_sort | Mikhaela B. Slavin |
| collection | DOAJ |
| description | In the broad field of inflammation, skeletal muscle is a tissue that is understudied. Yet it represents about 40% of body mass in non-obese individuals and is therefore of fundamental importance for whole body metabolism and health. This article provides an overview of the unique features of skeletal muscle tissue, as well as its adaptability to exercise. This ability to adapt, particularly with respect to mitochondrial content and function, confers a level of metabolic “protection” against energy consuming events, and adds a measure of quality control that determines the phenotypic response to stress. Thus, we describe the particular role of mitochondria in promoting inflammasome activation in skeletal muscle, contributing to muscle wasting and dysfunction in aging, disuse and metabolic disease. We will then discuss how exercise training can be anti-inflammatory, mitigating the chronic inflammation that is observed in these conditions, potentially through improvements in mitochondrial quality and function. |
| first_indexed | 2024-03-08T13:02:42Z |
| format | Article |
| id | doaj.art-e3143114cf824a3990c5303cf895a8dc |
| institution | Directory Open Access Journal |
| issn | 2319-4170 |
| language | English |
| last_indexed | 2024-04-24T18:47:55Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedical Journal |
| spelling | doaj.art-e3143114cf824a3990c5303cf895a8dc2024-03-27T04:52:18ZengElsevierBiomedical Journal2319-41702024-02-01471100636Exercise, mitochondrial dysfunction and inflammasomes in skeletal muscleMikhaela B. Slavin0Priyanka Khemraj1David A. Hood2School of Kinesiology and Health Science, Muscle Health Research Centre, York University, Toronto, ON, M3J 1P3, CanadaSchool of Kinesiology and Health Science, Muscle Health Research Centre, York University, Toronto, ON, M3J 1P3, CanadaCorresponding author. School of Kinesiology and Health Science, York University, 4700 Keele St., Toronto, ON, M3J 1P3, Canada.; School of Kinesiology and Health Science, Muscle Health Research Centre, York University, Toronto, ON, M3J 1P3, CanadaIn the broad field of inflammation, skeletal muscle is a tissue that is understudied. Yet it represents about 40% of body mass in non-obese individuals and is therefore of fundamental importance for whole body metabolism and health. This article provides an overview of the unique features of skeletal muscle tissue, as well as its adaptability to exercise. This ability to adapt, particularly with respect to mitochondrial content and function, confers a level of metabolic “protection” against energy consuming events, and adds a measure of quality control that determines the phenotypic response to stress. Thus, we describe the particular role of mitochondria in promoting inflammasome activation in skeletal muscle, contributing to muscle wasting and dysfunction in aging, disuse and metabolic disease. We will then discuss how exercise training can be anti-inflammatory, mitigating the chronic inflammation that is observed in these conditions, potentially through improvements in mitochondrial quality and function.http://www.sciencedirect.com/science/article/pii/S2319417023000732MitochondriaSkeletal muscleAgingMuscle disuseExerciseInflammation |
| spellingShingle | Mikhaela B. Slavin Priyanka Khemraj David A. Hood Exercise, mitochondrial dysfunction and inflammasomes in skeletal muscle Biomedical Journal Mitochondria Skeletal muscle Aging Muscle disuse Exercise Inflammation |
| title | Exercise, mitochondrial dysfunction and inflammasomes in skeletal muscle |
| title_full | Exercise, mitochondrial dysfunction and inflammasomes in skeletal muscle |
| title_fullStr | Exercise, mitochondrial dysfunction and inflammasomes in skeletal muscle |
| title_full_unstemmed | Exercise, mitochondrial dysfunction and inflammasomes in skeletal muscle |
| title_short | Exercise, mitochondrial dysfunction and inflammasomes in skeletal muscle |
| title_sort | exercise mitochondrial dysfunction and inflammasomes in skeletal muscle |
| topic | Mitochondria Skeletal muscle Aging Muscle disuse Exercise Inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S2319417023000732 |
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