Enzymatic one-step ring contraction for quinolone biosynthesis
Viridicatin is a fungal alkaloid. Here, the authors identify and characterize the cyclopenase that catalyzes the last step of its biosynthesis in Aspergillus nidulans, the conversion of cyclopenin to viridicatin, and find that the reaction proceeds via an unusual elimination mechanism.
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2018-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-05221-5 |
| _version_ | 1818952157630562304 |
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| author | Shinji Kishimoto Kodai Hara Hiroshi Hashimoto Yuichiro Hirayama Pier Alexandre Champagne Kendall N. Houk Yi Tang Kenji Watanabe |
| author_facet | Shinji Kishimoto Kodai Hara Hiroshi Hashimoto Yuichiro Hirayama Pier Alexandre Champagne Kendall N. Houk Yi Tang Kenji Watanabe |
| author_sort | Shinji Kishimoto |
| collection | DOAJ |
| description | Viridicatin is a fungal alkaloid. Here, the authors identify and characterize the cyclopenase that catalyzes the last step of its biosynthesis in Aspergillus nidulans, the conversion of cyclopenin to viridicatin, and find that the reaction proceeds via an unusual elimination mechanism. |
| first_indexed | 2024-12-20T09:45:55Z |
| format | Article |
| id | doaj.art-e314b137eb8e447180aa93d7b1b86b62 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T09:45:55Z |
| publishDate | 2018-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-e314b137eb8e447180aa93d7b1b86b622022-12-21T19:44:45ZengNature PortfolioNature Communications2041-17232018-07-01911710.1038/s41467-018-05221-5Enzymatic one-step ring contraction for quinolone biosynthesisShinji Kishimoto0Kodai Hara1Hiroshi Hashimoto2Yuichiro Hirayama3Pier Alexandre Champagne4Kendall N. Houk5Yi Tang6Kenji Watanabe7Department of Pharmaceutical Sciences, University of ShizuokaDepartment of Pharmaceutical Sciences, University of ShizuokaDepartment of Pharmaceutical Sciences, University of ShizuokaDepartment of Pharmaceutical Sciences, University of ShizuokaDepartment of Chemistry and Biochemistry, University of CaliforniaDepartment of Chemistry and Biochemistry, University of CaliforniaDepartment of Chemistry and Biochemistry, University of CaliforniaDepartment of Pharmaceutical Sciences, University of ShizuokaViridicatin is a fungal alkaloid. Here, the authors identify and characterize the cyclopenase that catalyzes the last step of its biosynthesis in Aspergillus nidulans, the conversion of cyclopenin to viridicatin, and find that the reaction proceeds via an unusual elimination mechanism.https://doi.org/10.1038/s41467-018-05221-5 |
| spellingShingle | Shinji Kishimoto Kodai Hara Hiroshi Hashimoto Yuichiro Hirayama Pier Alexandre Champagne Kendall N. Houk Yi Tang Kenji Watanabe Enzymatic one-step ring contraction for quinolone biosynthesis Nature Communications |
| title | Enzymatic one-step ring contraction for quinolone biosynthesis |
| title_full | Enzymatic one-step ring contraction for quinolone biosynthesis |
| title_fullStr | Enzymatic one-step ring contraction for quinolone biosynthesis |
| title_full_unstemmed | Enzymatic one-step ring contraction for quinolone biosynthesis |
| title_short | Enzymatic one-step ring contraction for quinolone biosynthesis |
| title_sort | enzymatic one step ring contraction for quinolone biosynthesis |
| url | https://doi.org/10.1038/s41467-018-05221-5 |
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