An ionophore breaks the multi-drug-resistance of Acinetobacter baumannii
Within intensive care units, multi-drug resistant Aci-netobacter baumannii outbreaks are a frequent cause of ventilator-associated pneumonia. During the on-going COVID-19 pandemic, patients who receive venti-lator support experience a 2-fold increased risk of mor-tality when they contract a secondar...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Shared Science Publishers OG
2022-02-01
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| Series: | Microbial Cell |
| Subjects: | |
| Online Access: | http://microbialcell.com/researcharticles/2022a-de-oliveira-microbial-cell/ |
| _version_ | 1826532128601407488 |
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| author | David M.P. De Oliveira Mark J. Walker |
| author_facet | David M.P. De Oliveira Mark J. Walker |
| author_sort | David M.P. De Oliveira |
| collection | DOAJ |
| description | Within intensive care units, multi-drug resistant Aci-netobacter baumannii outbreaks are a frequent cause of ventilator-associated pneumonia. During the on-going COVID-19 pandemic, patients who receive venti-lator support experience a 2-fold increased risk of mor-tality when they contract a secondary A. baumannii pulmonary infection. In our recent paper (De Oliveira et al. (2022), Mbio, doi: 10.1128/mbio.03517-21), we demonstrate that the 8-hydroxquinoline ionophore, PBT2 breaks the resistance of A. baumannii to tetracy-cline class antibiotics. In vitro, the combination of PBT2 and zinc with either tetracycline, doxycycline, or tigecy-cline was shown to be bactericidal against multi-drug-resistant A. baumannii, and any resistance that did arise imposed a fitness cost. Using a murine model of pulmo-nary infection, treatment with PBT2 in combination with tetracycline or tigecycline proved efficacious against multidrug-resistant A. baumannii. These find-ings suggest that PBT2 may find utility as a resistance breaker to rescue the efficacy of tetracycline-class anti-biotics commonly employed to treat multi-drug re-sistant A. baumannii infections. |
| first_indexed | 2024-12-13T12:54:36Z |
| format | Article |
| id | doaj.art-e315cf518c0840aabad91d6643e8b523 |
| institution | Directory Open Access Journal |
| issn | 2311-2638 |
| language | English |
| last_indexed | 2025-03-14T01:46:19Z |
| publishDate | 2022-02-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Microbial Cell |
| spelling | doaj.art-e315cf518c0840aabad91d6643e8b5232025-03-12T13:46:40ZengShared Science Publishers OGMicrobial Cell2311-26382022-02-0193697110.15698/mic2022.03.772An ionophore breaks the multi-drug-resistance of Acinetobacter baumanniiDavid M.P. De Oliveira0Mark J. Walker1The University of Queensland, School of Chemistry and Molecular Biosciences, Australian Infectious Diseases Research Centre, Bris-bane, QLD, Australia.The University of Queensland, School of Chemistry and Molecular Biosciences, Australian Infectious Diseases Research Centre, Bris-bane, QLD, Australia.Within intensive care units, multi-drug resistant Aci-netobacter baumannii outbreaks are a frequent cause of ventilator-associated pneumonia. During the on-going COVID-19 pandemic, patients who receive venti-lator support experience a 2-fold increased risk of mor-tality when they contract a secondary A. baumannii pulmonary infection. In our recent paper (De Oliveira et al. (2022), Mbio, doi: 10.1128/mbio.03517-21), we demonstrate that the 8-hydroxquinoline ionophore, PBT2 breaks the resistance of A. baumannii to tetracy-cline class antibiotics. In vitro, the combination of PBT2 and zinc with either tetracycline, doxycycline, or tigecy-cline was shown to be bactericidal against multi-drug-resistant A. baumannii, and any resistance that did arise imposed a fitness cost. Using a murine model of pulmo-nary infection, treatment with PBT2 in combination with tetracycline or tigecycline proved efficacious against multidrug-resistant A. baumannii. These find-ings suggest that PBT2 may find utility as a resistance breaker to rescue the efficacy of tetracycline-class anti-biotics commonly employed to treat multi-drug re-sistant A. baumannii infections.http://microbialcell.com/researcharticles/2022a-de-oliveira-microbial-cell/ionophorepbt2antimicrobial resistanceacinetobacter baumanniitetracyclines |
| spellingShingle | David M.P. De Oliveira Mark J. Walker An ionophore breaks the multi-drug-resistance of Acinetobacter baumannii Microbial Cell ionophore pbt2 antimicrobial resistance acinetobacter baumannii tetracyclines |
| title | An ionophore breaks the multi-drug-resistance of Acinetobacter baumannii |
| title_full | An ionophore breaks the multi-drug-resistance of Acinetobacter baumannii |
| title_fullStr | An ionophore breaks the multi-drug-resistance of Acinetobacter baumannii |
| title_full_unstemmed | An ionophore breaks the multi-drug-resistance of Acinetobacter baumannii |
| title_short | An ionophore breaks the multi-drug-resistance of Acinetobacter baumannii |
| title_sort | ionophore breaks the multi drug resistance of acinetobacter baumannii |
| topic | ionophore pbt2 antimicrobial resistance acinetobacter baumannii tetracyclines |
| url | http://microbialcell.com/researcharticles/2022a-de-oliveira-microbial-cell/ |
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