A novel role for the ROS-ATM-Chk2 axis mediated metabolic and cell cycle reprogramming in the M1 macrophage polarization

A novel role for the ROS-ATM-Chk2 axis mediated metabolic and cell cycle reprogramming in the M1 macrophage polarization

Reactive oxygen species (ROS) play a pivotal role in macrophage-mediated acute inflammation. However, the precise molecular mechanism by which ROS regulate macrophage polarization remains unclear. Here, we show that ROS function as signaling molecules that regulate M1 macrophage polarization through...

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Bibliographic Details
Main Authors: Chunlu Li, Chengsi Deng, Siwei Wang, Xiang Dong, Bing Dai, Wendong Guo, Qiqiang Guo, Yanling Feng, Hongde Xu, Xiaoyu Song, Liu Cao
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Redox Biology
Subjects:
Macrophage
ROS
Chk2
PKM2
p21
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724000351

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