Importance of subchondral bone in the pathogenesis and management of osteoarthritis from bench to bed
Osteoarthritis (OA) is the most common form of joint disorders, which is the leading cause of pain and walking disability in older adults. The primary concern of OA is loss of articular cartilage. Yet the integrity of articular cartilage relies on subchondral bone to provide mechanical support and n...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2014-01-01
|
| Series: | Journal of Orthopaedic Translation |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214031X1300051X |
| _version_ | 1818140168021868544 |
|---|---|
| author | Chunyi Wen Weijia William Lu Kwong Yuen Chiu |
| author_facet | Chunyi Wen Weijia William Lu Kwong Yuen Chiu |
| author_sort | Chunyi Wen |
| collection | DOAJ |
| description | Osteoarthritis (OA) is the most common form of joint disorders, which is the leading cause of pain and walking disability in older adults. The primary concern of OA is loss of articular cartilage. Yet the integrity of articular cartilage relies on subchondral bone to provide mechanical support and nutrition supply. The term “osteo”-arthritis has indicated the importance of subchondral bone in the pathogenesis and management of knee OA. This review focuses on the current understanding of subchondral bone pathophysiology in human and animal models, and discusses how to translate it from bench to bedside for early diagnosis and intervention of OA. |
| first_indexed | 2024-12-11T10:39:41Z |
| format | Article |
| id | doaj.art-e316d678b6374725a81807606007887e |
| institution | Directory Open Access Journal |
| issn | 2214-031X |
| language | English |
| last_indexed | 2024-12-11T10:39:41Z |
| publishDate | 2014-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Orthopaedic Translation |
| spelling | doaj.art-e316d678b6374725a81807606007887e2022-12-22T01:10:38ZengElsevierJournal of Orthopaedic Translation2214-031X2014-01-0121162510.1016/j.jot.2013.11.004Importance of subchondral bone in the pathogenesis and management of osteoarthritis from bench to bedChunyi WenWeijia William LuKwong Yuen ChiuOsteoarthritis (OA) is the most common form of joint disorders, which is the leading cause of pain and walking disability in older adults. The primary concern of OA is loss of articular cartilage. Yet the integrity of articular cartilage relies on subchondral bone to provide mechanical support and nutrition supply. The term “osteo”-arthritis has indicated the importance of subchondral bone in the pathogenesis and management of knee OA. This review focuses on the current understanding of subchondral bone pathophysiology in human and animal models, and discusses how to translate it from bench to bedside for early diagnosis and intervention of OA.http://www.sciencedirect.com/science/article/pii/S2214031X1300051XAnimal modelArticular cartilageOsteoarthritisSubchondral bone |
| spellingShingle | Chunyi Wen Weijia William Lu Kwong Yuen Chiu Importance of subchondral bone in the pathogenesis and management of osteoarthritis from bench to bed Journal of Orthopaedic Translation Animal model Articular cartilage Osteoarthritis Subchondral bone |
| title | Importance of subchondral bone in the pathogenesis and management of osteoarthritis from bench to bed |
| title_full | Importance of subchondral bone in the pathogenesis and management of osteoarthritis from bench to bed |
| title_fullStr | Importance of subchondral bone in the pathogenesis and management of osteoarthritis from bench to bed |
| title_full_unstemmed | Importance of subchondral bone in the pathogenesis and management of osteoarthritis from bench to bed |
| title_short | Importance of subchondral bone in the pathogenesis and management of osteoarthritis from bench to bed |
| title_sort | importance of subchondral bone in the pathogenesis and management of osteoarthritis from bench to bed |
| topic | Animal model Articular cartilage Osteoarthritis Subchondral bone |
| url | http://www.sciencedirect.com/science/article/pii/S2214031X1300051X |
| work_keys_str_mv | AT chunyiwen importanceofsubchondralboneinthepathogenesisandmanagementofosteoarthritisfrombenchtobed AT weijiawilliamlu importanceofsubchondralboneinthepathogenesisandmanagementofosteoarthritisfrombenchtobed AT kwongyuenchiu importanceofsubchondralboneinthepathogenesisandmanagementofosteoarthritisfrombenchtobed |