Exosomes derived from adipose-derived stem cells overexpressing glyoxalase-1 protect endothelial cells and enhance angiogenesis in type 2 diabetic mice with limb ischemia

Exosomes derived from adipose-derived stem cells overexpressing glyoxalase-1 protect endothelial cells and enhance angiogenesis in type 2 diabetic mice with limb ischemia

Abstract Background Diabetic limb ischemia is a clinical syndrome and refractory to therapy. Our previous study demonstrated that adipose-derived stem cells (ADSCs) overexpressing glyoxalase-1 (GLO-1) promoted the regeneration of ischemic lower limbs in diabetic mice, but low survival rate, difficul...

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Bibliographic Details
Main Authors:	Xing Zhang, Yihong Jiang, Qun Huang, Zhaoyu Wu, Hongji Pu, Zhijue Xu, Bo Li, Xinwu Lu, Xinrui Yang, Jinbao Qin, Zhiyou Peng
Format:	Article
Language:	English
Published:	BMC 2021-07-01
Series:	Stem Cell Research & Therapy
Subjects:	Glyoxalase-1 Adipose-derived stem cells Exosomes T2DM Endothelial cells Angiogenesis
Online Access:	https://doi.org/10.1186/s13287-021-02475-7

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