BSA-assisted synthesis of nanoreactors with dual pH and glutathione responses for ferroptosis and photodynamic synergistic therapy of colorectal cancer
Colorectal cancer (CRC) is the third most common cancer in global incidence and second most common cancer in global mortality rates, accounting for 10% of all cancer cases and 9.4% of all cancer-related deaths. CRC is a heterogeneous disease, mostly comprising sporadic tumors. Approximately 19%–28%...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-12-01
|
| Series: | Materials Today Advances |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590049822001047 |
| _version_ | 1811178893485277184 |
|---|---|
| author | Xiaoyan Liang Min Mu Bo Chen Di Chuan Na Zhao Rangrang Fan Xin Tang Haifeng Chen Bo Han Gang Guo |
| author_facet | Xiaoyan Liang Min Mu Bo Chen Di Chuan Na Zhao Rangrang Fan Xin Tang Haifeng Chen Bo Han Gang Guo |
| author_sort | Xiaoyan Liang |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is the third most common cancer in global incidence and second most common cancer in global mortality rates, accounting for 10% of all cancer cases and 9.4% of all cancer-related deaths. CRC is a heterogeneous disease, mostly comprising sporadic tumors. Approximately 19%–28% of patients have postoperative metastasis. In this study, we report an epigallocatechin gallate (EGCG)-based metal polyphenol network (MPN) with CD44 targeting, glutathione (GSH) sensitivity and pH response for the codelivery of the photosensitizers chlorin e6 (Ce6) and Fe3+. Photodynamic therapy (PDT) has become a potential clinical treatment method because of its noninvasive nature, low toxicity and spatiotemporally controlled treatment capability. Ferroptosis is a nonapoptotic cell death caused by peroxidative modification of phospholipid membranes via iron-dependent mechanisms. We unified ferroptosis and PDT into a nanoreactor (BSA-Ce6@MPN, BCM) to treat CRC. In vitro analysis showed that laser-irradiated BCM increased the cellular reactive oxygen species (ROS) and lipid peroxide (LPO) contents and decreased the expression levels of GSH and glutathione peroxidase 4 (GPX4). BCM-mediated ferroptosis and PDT synergistic therapy were significantly effective in the CT26 tumor-bearing mouse model, demonstrating the efficacy of the combination therapy. These results suggest that the nanoreactor for the synergistic treatment of ferroptosis and PDT holds great promise for clinical translation. |
| first_indexed | 2024-04-11T06:25:40Z |
| format | Article |
| id | doaj.art-e317ee3e58fd471a9f18e766cb8a04b0 |
| institution | Directory Open Access Journal |
| issn | 2590-0498 |
| language | English |
| last_indexed | 2024-04-11T06:25:40Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Advances |
| spelling | doaj.art-e317ee3e58fd471a9f18e766cb8a04b02022-12-22T04:40:23ZengElsevierMaterials Today Advances2590-04982022-12-0116100308BSA-assisted synthesis of nanoreactors with dual pH and glutathione responses for ferroptosis and photodynamic synergistic therapy of colorectal cancerXiaoyan Liang0Min Mu1Bo Chen2Di Chuan3Na Zhao4Rangrang Fan5Xin Tang6Haifeng Chen7Bo Han8Gang Guo9State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, ChinaState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, ChinaState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, ChinaState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, ChinaSchool of Pharmacy, Shihezi University, Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, Shihezi, 832002, ChinaDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, 610041, ChinaDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, 610041, ChinaDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, 610041, ChinaSchool of Pharmacy, Shihezi University, Key Laboratory of Xinjiang Phytomedicine Resource and Utilization, Ministry of Education, Shihezi, 832002, ChinaState Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, China; Corresponding author.Colorectal cancer (CRC) is the third most common cancer in global incidence and second most common cancer in global mortality rates, accounting for 10% of all cancer cases and 9.4% of all cancer-related deaths. CRC is a heterogeneous disease, mostly comprising sporadic tumors. Approximately 19%–28% of patients have postoperative metastasis. In this study, we report an epigallocatechin gallate (EGCG)-based metal polyphenol network (MPN) with CD44 targeting, glutathione (GSH) sensitivity and pH response for the codelivery of the photosensitizers chlorin e6 (Ce6) and Fe3+. Photodynamic therapy (PDT) has become a potential clinical treatment method because of its noninvasive nature, low toxicity and spatiotemporally controlled treatment capability. Ferroptosis is a nonapoptotic cell death caused by peroxidative modification of phospholipid membranes via iron-dependent mechanisms. We unified ferroptosis and PDT into a nanoreactor (BSA-Ce6@MPN, BCM) to treat CRC. In vitro analysis showed that laser-irradiated BCM increased the cellular reactive oxygen species (ROS) and lipid peroxide (LPO) contents and decreased the expression levels of GSH and glutathione peroxidase 4 (GPX4). BCM-mediated ferroptosis and PDT synergistic therapy were significantly effective in the CT26 tumor-bearing mouse model, demonstrating the efficacy of the combination therapy. These results suggest that the nanoreactor for the synergistic treatment of ferroptosis and PDT holds great promise for clinical translation.http://www.sciencedirect.com/science/article/pii/S2590049822001047Colorectal cancerPhotodynamic therapyFerroptosisEpigallocatechin gallateHyaluronic acidMetal polyphenol network |
| spellingShingle | Xiaoyan Liang Min Mu Bo Chen Di Chuan Na Zhao Rangrang Fan Xin Tang Haifeng Chen Bo Han Gang Guo BSA-assisted synthesis of nanoreactors with dual pH and glutathione responses for ferroptosis and photodynamic synergistic therapy of colorectal cancer Materials Today Advances Colorectal cancer Photodynamic therapy Ferroptosis Epigallocatechin gallate Hyaluronic acid Metal polyphenol network |
| title | BSA-assisted synthesis of nanoreactors with dual pH and glutathione responses for ferroptosis and photodynamic synergistic therapy of colorectal cancer |
| title_full | BSA-assisted synthesis of nanoreactors with dual pH and glutathione responses for ferroptosis and photodynamic synergistic therapy of colorectal cancer |
| title_fullStr | BSA-assisted synthesis of nanoreactors with dual pH and glutathione responses for ferroptosis and photodynamic synergistic therapy of colorectal cancer |
| title_full_unstemmed | BSA-assisted synthesis of nanoreactors with dual pH and glutathione responses for ferroptosis and photodynamic synergistic therapy of colorectal cancer |
| title_short | BSA-assisted synthesis of nanoreactors with dual pH and glutathione responses for ferroptosis and photodynamic synergistic therapy of colorectal cancer |
| title_sort | bsa assisted synthesis of nanoreactors with dual ph and glutathione responses for ferroptosis and photodynamic synergistic therapy of colorectal cancer |
| topic | Colorectal cancer Photodynamic therapy Ferroptosis Epigallocatechin gallate Hyaluronic acid Metal polyphenol network |
| url | http://www.sciencedirect.com/science/article/pii/S2590049822001047 |
| work_keys_str_mv | AT xiaoyanliang bsaassistedsynthesisofnanoreactorswithdualphandglutathioneresponsesforferroptosisandphotodynamicsynergistictherapyofcolorectalcancer AT minmu bsaassistedsynthesisofnanoreactorswithdualphandglutathioneresponsesforferroptosisandphotodynamicsynergistictherapyofcolorectalcancer AT bochen bsaassistedsynthesisofnanoreactorswithdualphandglutathioneresponsesforferroptosisandphotodynamicsynergistictherapyofcolorectalcancer AT dichuan bsaassistedsynthesisofnanoreactorswithdualphandglutathioneresponsesforferroptosisandphotodynamicsynergistictherapyofcolorectalcancer AT nazhao bsaassistedsynthesisofnanoreactorswithdualphandglutathioneresponsesforferroptosisandphotodynamicsynergistictherapyofcolorectalcancer AT rangrangfan bsaassistedsynthesisofnanoreactorswithdualphandglutathioneresponsesforferroptosisandphotodynamicsynergistictherapyofcolorectalcancer AT xintang bsaassistedsynthesisofnanoreactorswithdualphandglutathioneresponsesforferroptosisandphotodynamicsynergistictherapyofcolorectalcancer AT haifengchen bsaassistedsynthesisofnanoreactorswithdualphandglutathioneresponsesforferroptosisandphotodynamicsynergistictherapyofcolorectalcancer AT bohan bsaassistedsynthesisofnanoreactorswithdualphandglutathioneresponsesforferroptosisandphotodynamicsynergistictherapyofcolorectalcancer AT gangguo bsaassistedsynthesisofnanoreactorswithdualphandglutathioneresponsesforferroptosisandphotodynamicsynergistictherapyofcolorectalcancer |