Expression of Pgp in cells of neurovascular unit in perinatal hypoxic-ischemic brain injury
We have studied peculiarities of P-glycoprotein (Pgp) expressionon neuronal, astroglial and endothelial cells in newborn rats (P10)underwent perinatal hypoxic-ischemic brain damage. Expressionof Pgp was markedly elevated in all the cells tested reaching thehighest levels in astrocytes (4 hrs after i...
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| Format: | Article |
| Language: | English |
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Research Center of Neurology
2017-02-01
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| Series: | Анналы клинической и экспериментальной неврологии |
| Subjects: | |
| Online Access: | https://annaly-nevrologii.com/journal/pathID/article/viewFile/192/36 |
| _version_ | 1811244307718340608 |
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| author | A. V. Morgun T. E. Taranushenko N. A. Malinovskaya O. S. Okuneva S. I. Ustinova L. N. Karpova A. B. Salmina E. A. Pozhilenkova D. I. Laletin O. V. Frolova N. V. Reusheva L. V. Trufanova |
| author_facet | A. V. Morgun T. E. Taranushenko N. A. Malinovskaya O. S. Okuneva S. I. Ustinova L. N. Karpova A. B. Salmina E. A. Pozhilenkova D. I. Laletin O. V. Frolova N. V. Reusheva L. V. Trufanova |
| author_sort | A. V. Morgun |
| collection | DOAJ |
| description | We have studied peculiarities of P-glycoprotein (Pgp) expressionon neuronal, astroglial and endothelial cells in newborn rats (P10)underwent perinatal hypoxic-ischemic brain damage. Expressionof Pgp was markedly elevated in all the cells tested reaching thehighest levels in astrocytes (4 hrs after injury) followed by increasedlevels in neuronal and endothelial cells (12 hrs after injury). Thepossible role of Pgp in pathogenesis of perinatal brain injury is discussed. |
| first_indexed | 2024-04-12T14:22:27Z |
| format | Article |
| id | doaj.art-e3190735389a432bbb392948eadf2103 |
| institution | Directory Open Access Journal |
| issn | 2075-5473 2409-2533 |
| language | English |
| last_indexed | 2024-04-12T14:22:27Z |
| publishDate | 2017-02-01 |
| publisher | Research Center of Neurology |
| record_format | Article |
| series | Анналы клинической и экспериментальной неврологии |
| spelling | doaj.art-e3190735389a432bbb392948eadf21032022-12-22T03:29:32ZengResearch Center of NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-25332017-02-0181404310.17816/psaic19298Expression of Pgp in cells of neurovascular unit in perinatal hypoxic-ischemic brain injuryA. V. Morgun0T. E. Taranushenko1N. A. Malinovskaya2O. S. Okuneva3S. I. Ustinova4L. N. Karpova5A. B. Salmina6E. A. Pozhilenkova7D. I. Laletin8O. V. Frolova9N. V. Reusheva10L. V. Trufanova11Krasnoyarsk State Medical University named after Professor V.F. Voino-YasenetskyKrasnoyarsk State Medical University named after Professor V.F. Voino-YasenetskyKrasnoyarsk State Medical University named after Professor V.F. Voino-YasenetskyKrasnoyarsk State Medical University named after Professor V.F. Voino-YasenetskyKrasnoyarsk State Medical University named after Professor V.F. Voino-YasenetskyKrasnoyarsk State Medical University named after Professor V.F. Voino-YasenetskyKrasnoyarsk State Medical University named after Professor V.F. Voino-YasenetskyKrasnoyarsk State Medical University named after Professor V.F. Voino-YasenetskyKrasnoyarsk State Medical University named after Professor V.F. Voino-YasenetskyKrasnoyarsk State Medical University named after Professor V.F. Voino-YasenetskyKrasnoyarsk State Medical University named after Professor V.F. Voino-YasenetskyKrasnoyarsk State Medical University named after Professor V.F. Voino-YasenetskyWe have studied peculiarities of P-glycoprotein (Pgp) expressionon neuronal, astroglial and endothelial cells in newborn rats (P10)underwent perinatal hypoxic-ischemic brain damage. Expressionof Pgp was markedly elevated in all the cells tested reaching thehighest levels in astrocytes (4 hrs after injury) followed by increasedlevels in neuronal and endothelial cells (12 hrs after injury). Thepossible role of Pgp in pathogenesis of perinatal brain injury is discussed.https://annaly-nevrologii.com/journal/pathID/article/viewFile/192/36p-glycoprotein/pgpperinatal brain injuryneurovascular unit |
| spellingShingle | A. V. Morgun T. E. Taranushenko N. A. Malinovskaya O. S. Okuneva S. I. Ustinova L. N. Karpova A. B. Salmina E. A. Pozhilenkova D. I. Laletin O. V. Frolova N. V. Reusheva L. V. Trufanova Expression of Pgp in cells of neurovascular unit in perinatal hypoxic-ischemic brain injury Анналы клинической и экспериментальной неврологии p-glycoprotein/pgp perinatal brain injury neurovascular unit |
| title | Expression of Pgp in cells of neurovascular unit in perinatal hypoxic-ischemic brain injury |
| title_full | Expression of Pgp in cells of neurovascular unit in perinatal hypoxic-ischemic brain injury |
| title_fullStr | Expression of Pgp in cells of neurovascular unit in perinatal hypoxic-ischemic brain injury |
| title_full_unstemmed | Expression of Pgp in cells of neurovascular unit in perinatal hypoxic-ischemic brain injury |
| title_short | Expression of Pgp in cells of neurovascular unit in perinatal hypoxic-ischemic brain injury |
| title_sort | expression of pgp in cells of neurovascular unit in perinatal hypoxic ischemic brain injury |
| topic | p-glycoprotein/pgp perinatal brain injury neurovascular unit |
| url | https://annaly-nevrologii.com/journal/pathID/article/viewFile/192/36 |
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