CRISPR/Cas9 genome editing to create nonhuman primate models for studying stem cell therapies for HIV infection

CRISPR/Cas9 genome editing to create nonhuman primate models for studying stem cell therapies for HIV infection

Abstract Nonhuman primates (NHPs) are well-established basic and translational research models for human immunodeficiency virus (HIV) infections and pathophysiology, hematopoietic stem cell (HSC) transplantation, and assisted reproductive technologies. Recent advances in CRISPR/Cas9 gene editing tec...

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Bibliographic Details
Main Authors: Jenna Kropp Schmidt, Matthew R. Reynolds, Thaddeus G. Golos, Igor I. Slukvin
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Retrovirology
Subjects:
Nonhuman primates
HIV
SIV
CRISPR/Cas9
CCR5
HSC transplantation
Online Access:https://doi.org/10.1186/s12977-022-00604-5

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