Urinary Cell Transcriptome Profiling and Identification of ITM2A, SLAMF6, and IKZF3 as Biomarkers of Acute Rejection in Human Kidney Allografts

Urinary Cell Transcriptome Profiling and Identification of ITM2A, SLAMF6, and IKZF3 as Biomarkers of Acute Rejection in Human Kidney Allografts

Background. Identification of a shared gene expression pattern between T cell–mediated rejection (TCMR) and antibody-mediated rejection (AMR) in human kidney allografts may help prioritize targets for the treatment of both types of acute rejection. Methods. We performed RNA sequencing and bioinforma...

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Main Authors: Bryan J. Dooley, MD, Akanksha Verma, BA, Ruchuang Ding, MD, Hua Yang, MD, Thangamani Muthukumar, MD, Michele Lubetzky, MD, Divya Shankaranarayanan, MD, Olivier Elemento, PhD, Manikkam Suthanthiran, MD
Format: Article
Language:English
Published: Wolters Kluwer 2020-08-01
Series:Transplantation Direct
Online Access:http://journals.lww.com/transplantationdirect/fulltext/10.1097/TXD.0000000000001035

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