Localization microscopy (SPDM) reveals clustered formations of P-glycoprotein in a human blood-brain barrier model.

Localization microscopy (SPDM) reveals clustered formations of P-glycoprotein in a human blood-brain barrier model.

P-glycoprotein (Pgp; also known as MDR1, ABCB1) is the most important and best studied efflux transporter at the blood-brain barrier (BBB); however, the organization of Pgp is unknown. The aim of this study was to employ the recently developed super-resolution fluorescence microscopy method spectral...

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Bibliographic Details
Main Authors: Olga Huber, Alexander Brunner, Patrick Maier, Rainer Kaufmann, Pierre-Olivier Couraud, Christoph Cremer, Gert Fricker
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3440331?pdf=render

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