Evaluation of Some Serum Antioxidants in Mandibular Bone Defect Healing in Rabbits Orally Supplemented with Pomegranate Peel Extract
Background: Pomegranate (PG) fruit (punicagranatum L, Punicaceae contains many bioactive substances that play important role in the treatment of a variety of medical problems. Among PG parts, it was observed that the peel had the most potent antioxidant activity. Objective: To evaluate some seru...
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| Format: | Article |
| Language: | English |
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College of medicine/ University of Diyala
2021-10-01
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| Series: | Diyala Journal of Medicine |
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| Online Access: | https://www.djm.uodiyala.edu.iq/index.php/djm/article/view/836 |
| _version_ | 1827690318234910720 |
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| author | Sarchil Ezadeen Mohyadeen Rezan Majeed Omer Bakhtiar Muhialdin Ahmed |
| author_facet | Sarchil Ezadeen Mohyadeen Rezan Majeed Omer Bakhtiar Muhialdin Ahmed |
| author_sort | Sarchil Ezadeen Mohyadeen |
| collection | DOAJ |
| description |
Background: Pomegranate (PG) fruit (punicagranatum L, Punicaceae contains many bioactive substances that play important role in the treatment of a variety of medical problems. Among PG parts, it was observed that the peel had the most potent antioxidant activity.
Objective: To evaluate some serum antioxidants levels in mandibular bone injury healing in rabbits orally supplemented with pomegranate peel extract (PPE).
Patients and Methods: Forty-five male rabbits (1-1.2 kg) were used and they were divided into 3 groups; the baseline group consisted of 5 rabbits without creating mandibular bone defects. 20 rabbits were used as a study group with creating mandibular bone defects and they received orally 1ml/day of PPE. Another 20 rabbits were used as a control group with creating mandibular bone defects without receiving PPE. For each rabbit of both study and control groups, a circular defect of 3 mm in diameter was made in the mid labial area of the alveolar bone of the lower right central incisor. Blood samples were taken from the baseline group and both the study and control groups at time intervals; 3hrs, 1, 3, and 7days after bone defect creation, for estimation of serum albumin (Alb), bilirubin (Bili), zinc (Zn), and magnesium (Mg) levels.
Results: Serum Bili levels significantly increased 1and 3 days after bone defect creation in both study and control groups, while the levels returned back to baseline in a study group, 7 days after the operation. Serum Alb, Zn, and Mg levels showed a significant decrease in study and control groups, 1 day and 3 days after the operation, while the levels of these parameters returned back to baseline, in a study group, 7 days after bone defect.
Conclusion: Supplementation of PPE can affect serum antioxidants and this was accompanied by the increase in the bone healing rate process.
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| first_indexed | 2024-03-10T10:35:37Z |
| format | Article |
| id | doaj.art-e31cbe855aaa416e80c9aab45bf8ecbc |
| institution | Directory Open Access Journal |
| issn | 2219-9764 2617-8982 |
| language | English |
| last_indexed | 2024-03-10T10:35:37Z |
| publishDate | 2021-10-01 |
| publisher | College of medicine/ University of Diyala |
| record_format | Article |
| series | Diyala Journal of Medicine |
| spelling | doaj.art-e31cbe855aaa416e80c9aab45bf8ecbc2023-11-21T23:20:37ZengCollege of medicine/ University of DiyalaDiyala Journal of Medicine2219-97642617-89822021-10-01211Evaluation of Some Serum Antioxidants in Mandibular Bone Defect Healing in Rabbits Orally Supplemented with Pomegranate Peel ExtractSarchil Ezadeen Mohyadeen Rezan Majeed OmerBakhtiar Muhialdin Ahmed Background: Pomegranate (PG) fruit (punicagranatum L, Punicaceae contains many bioactive substances that play important role in the treatment of a variety of medical problems. Among PG parts, it was observed that the peel had the most potent antioxidant activity. Objective: To evaluate some serum antioxidants levels in mandibular bone injury healing in rabbits orally supplemented with pomegranate peel extract (PPE). Patients and Methods: Forty-five male rabbits (1-1.2 kg) were used and they were divided into 3 groups; the baseline group consisted of 5 rabbits without creating mandibular bone defects. 20 rabbits were used as a study group with creating mandibular bone defects and they received orally 1ml/day of PPE. Another 20 rabbits were used as a control group with creating mandibular bone defects without receiving PPE. For each rabbit of both study and control groups, a circular defect of 3 mm in diameter was made in the mid labial area of the alveolar bone of the lower right central incisor. Blood samples were taken from the baseline group and both the study and control groups at time intervals; 3hrs, 1, 3, and 7days after bone defect creation, for estimation of serum albumin (Alb), bilirubin (Bili), zinc (Zn), and magnesium (Mg) levels. Results: Serum Bili levels significantly increased 1and 3 days after bone defect creation in both study and control groups, while the levels returned back to baseline in a study group, 7 days after the operation. Serum Alb, Zn, and Mg levels showed a significant decrease in study and control groups, 1 day and 3 days after the operation, while the levels of these parameters returned back to baseline, in a study group, 7 days after bone defect. Conclusion: Supplementation of PPE can affect serum antioxidants and this was accompanied by the increase in the bone healing rate process. https://www.djm.uodiyala.edu.iq/index.php/djm/article/view/836Pomegranate peel, mandibular bone defect, albumin, bilirubin, divalent cations, antioxidant |
| spellingShingle | Sarchil Ezadeen Mohyadeen Rezan Majeed Omer Bakhtiar Muhialdin Ahmed Evaluation of Some Serum Antioxidants in Mandibular Bone Defect Healing in Rabbits Orally Supplemented with Pomegranate Peel Extract Diyala Journal of Medicine Pomegranate peel, mandibular bone defect, albumin, bilirubin, divalent cations, antioxidant |
| title | Evaluation of Some Serum Antioxidants in Mandibular Bone Defect Healing in Rabbits Orally Supplemented with Pomegranate Peel Extract |
| title_full | Evaluation of Some Serum Antioxidants in Mandibular Bone Defect Healing in Rabbits Orally Supplemented with Pomegranate Peel Extract |
| title_fullStr | Evaluation of Some Serum Antioxidants in Mandibular Bone Defect Healing in Rabbits Orally Supplemented with Pomegranate Peel Extract |
| title_full_unstemmed | Evaluation of Some Serum Antioxidants in Mandibular Bone Defect Healing in Rabbits Orally Supplemented with Pomegranate Peel Extract |
| title_short | Evaluation of Some Serum Antioxidants in Mandibular Bone Defect Healing in Rabbits Orally Supplemented with Pomegranate Peel Extract |
| title_sort | evaluation of some serum antioxidants in mandibular bone defect healing in rabbits orally supplemented with pomegranate peel extract |
| topic | Pomegranate peel, mandibular bone defect, albumin, bilirubin, divalent cations, antioxidant |
| url | https://www.djm.uodiyala.edu.iq/index.php/djm/article/view/836 |
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