Pain-Related Brain Connectivity Changes in Migraine: A Narrative Review and Proof of Concept about Possible Novel Treatments Interference
A neuronal dysfunction based on the imbalance between excitatory and inhibitory cortical-subcortical neurotransmission seems at the basis of migraine. Intercritical neuronal abnormal excitability can culminate in the bioelectrical phenomenon of Cortical Spreading Depression (CSD) with secondary invo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Brain Sciences |
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| Online Access: | https://www.mdpi.com/2076-3425/11/2/234 |
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| author | Marina de Tommaso Eleonora Vecchio Silvia Giovanna Quitadamo Gianluca Coppola Antonio Di Renzo Vincenzo Parisi Marcello Silvestro Antonio Russo Gioacchino Tedeschi |
| author_facet | Marina de Tommaso Eleonora Vecchio Silvia Giovanna Quitadamo Gianluca Coppola Antonio Di Renzo Vincenzo Parisi Marcello Silvestro Antonio Russo Gioacchino Tedeschi |
| author_sort | Marina de Tommaso |
| collection | DOAJ |
| description | A neuronal dysfunction based on the imbalance between excitatory and inhibitory cortical-subcortical neurotransmission seems at the basis of migraine. Intercritical neuronal abnormal excitability can culminate in the bioelectrical phenomenon of Cortical Spreading Depression (CSD) with secondary involvement of the vascular system and release of inflammatory mediators, modulating in turn neuronal activity. Neuronal dysfunction encompasses the altered connectivity between the brain areas implicated in the genesis, maintenance and chronic evolution of migraine. Advanced neuroimaging techniques allow to identify changes in functional connectivity (FC) between brain areas involved in pain processes. Through a narrative review, we re-searched case-control studies on FC in migraine, between 2015 and 2020, by inserting the words migraine, fMRI, EEG, MEG, connectivity, pain in Pubmed. Studies on FC have shown that cortical processes, in the neurolimbic pain network, are likely to be prevalent for triggering attacks, in response to predisposing factors, and that these lead to a demodulation of the subcortical areas, at the basis of migraine maintenance. The link between brain dysfunction and peripheral interactions through the inhibition of CGRP, the main mediator of sterile migraine inflammation needs to be further investigated. Preliminary evidence could suggest that peripheral nerves inference at somatic and trigeminal levels, appears to change brain FC. |
| first_indexed | 2024-03-09T00:56:06Z |
| format | Article |
| id | doaj.art-e31fec85819143e0941f53b9f1c54daf |
| institution | Directory Open Access Journal |
| issn | 2076-3425 |
| language | English |
| last_indexed | 2024-03-09T00:56:06Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Brain Sciences |
| spelling | doaj.art-e31fec85819143e0941f53b9f1c54daf2023-12-11T16:56:28ZengMDPI AGBrain Sciences2076-34252021-02-0111223410.3390/brainsci11020234Pain-Related Brain Connectivity Changes in Migraine: A Narrative Review and Proof of Concept about Possible Novel Treatments InterferenceMarina de Tommaso0Eleonora Vecchio1Silvia Giovanna Quitadamo2Gianluca Coppola3Antonio Di Renzo4Vincenzo Parisi5Marcello Silvestro6Antonio Russo7Gioacchino Tedeschi8Applied Neurophysiology and Pain Unit, Bari Aldo Moro University, 70121 Bari, ItalyApplied Neurophysiology and Pain Unit, Bari Aldo Moro University, 70121 Bari, ItalyApplied Neurophysiology and Pain Unit, Bari Aldo Moro University, 70121 Bari, ItalyDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome Polo Pontino, Latina, 00185 Rome, ItalyIRCCS—Fondazione Bietti, 00198 Rome, ItalyIRCCS—Fondazione Bietti, 00198 Rome, ItalyClinica Neurologica e Neurofisiopatologia Università della Campania ‘Luigi Vanvitelli’, 81100 Napoli, ItalyClinica Neurologica e Neurofisiopatologia Università della Campania ‘Luigi Vanvitelli’, 81100 Napoli, ItalyClinica Neurologica e Neurofisiopatologia Università della Campania ‘Luigi Vanvitelli’, 81100 Napoli, ItalyA neuronal dysfunction based on the imbalance between excitatory and inhibitory cortical-subcortical neurotransmission seems at the basis of migraine. Intercritical neuronal abnormal excitability can culminate in the bioelectrical phenomenon of Cortical Spreading Depression (CSD) with secondary involvement of the vascular system and release of inflammatory mediators, modulating in turn neuronal activity. Neuronal dysfunction encompasses the altered connectivity between the brain areas implicated in the genesis, maintenance and chronic evolution of migraine. Advanced neuroimaging techniques allow to identify changes in functional connectivity (FC) between brain areas involved in pain processes. Through a narrative review, we re-searched case-control studies on FC in migraine, between 2015 and 2020, by inserting the words migraine, fMRI, EEG, MEG, connectivity, pain in Pubmed. Studies on FC have shown that cortical processes, in the neurolimbic pain network, are likely to be prevalent for triggering attacks, in response to predisposing factors, and that these lead to a demodulation of the subcortical areas, at the basis of migraine maintenance. The link between brain dysfunction and peripheral interactions through the inhibition of CGRP, the main mediator of sterile migraine inflammation needs to be further investigated. Preliminary evidence could suggest that peripheral nerves inference at somatic and trigeminal levels, appears to change brain FC.https://www.mdpi.com/2076-3425/11/2/234migrainepathophysiologybrain connectivityFMRIEEGMEG |
| spellingShingle | Marina de Tommaso Eleonora Vecchio Silvia Giovanna Quitadamo Gianluca Coppola Antonio Di Renzo Vincenzo Parisi Marcello Silvestro Antonio Russo Gioacchino Tedeschi Pain-Related Brain Connectivity Changes in Migraine: A Narrative Review and Proof of Concept about Possible Novel Treatments Interference Brain Sciences migraine pathophysiology brain connectivity FMRI EEG MEG |
| title | Pain-Related Brain Connectivity Changes in Migraine: A Narrative Review and Proof of Concept about Possible Novel Treatments Interference |
| title_full | Pain-Related Brain Connectivity Changes in Migraine: A Narrative Review and Proof of Concept about Possible Novel Treatments Interference |
| title_fullStr | Pain-Related Brain Connectivity Changes in Migraine: A Narrative Review and Proof of Concept about Possible Novel Treatments Interference |
| title_full_unstemmed | Pain-Related Brain Connectivity Changes in Migraine: A Narrative Review and Proof of Concept about Possible Novel Treatments Interference |
| title_short | Pain-Related Brain Connectivity Changes in Migraine: A Narrative Review and Proof of Concept about Possible Novel Treatments Interference |
| title_sort | pain related brain connectivity changes in migraine a narrative review and proof of concept about possible novel treatments interference |
| topic | migraine pathophysiology brain connectivity FMRI EEG MEG |
| url | https://www.mdpi.com/2076-3425/11/2/234 |
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