Peptide-Based Nanoparticles for Systemic Extrahepatic Delivery of Therapeutic Nucleotides

Peptide-Based Nanoparticles for Systemic Extrahepatic Delivery of Therapeutic Nucleotides

Peptide-based nanoparticles (PBN) for nucleotide complexation and targeting of extrahepatic diseases are gaining recognition as potent pharmaceutical vehicles for fine-tuned control of protein production (up- and/or down-regulation) and for gene delivery. Herein, we review the principles and mechani...

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Bibliographic Details
Main Authors: Samuel A. Wickline, Kirk K. Hou, Hua Pan
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:International Journal of Molecular Sciences
Subjects:
nanoparticles
peptide polyplexes
RNA
siRNA
mRNA
nucleic acids
Online Access:https://www.mdpi.com/1422-0067/24/11/9455

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