PD-1-Associated Gene Expression Signature of Neoadjuvant Trastuzumab-Treated Tumors Correlates with Patient Survival in HER2-Positive Breast Cancer

PD-1-Associated Gene Expression Signature of Neoadjuvant Trastuzumab-Treated Tumors Correlates with Patient Survival in HER2-Positive Breast Cancer

The therapeutic HER2-targeting antibody trastuzumab has been shown to elicit tumor immune response in a subset of HER2-positive (HER2+) breast cancer. We performed genomic and immunohistochemical profiling of tumors from eight patients who have completed multiple rounds of neoadjuvant trastuzumabb t...

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Bibliographic Details
Main Authors: William P. D. Hendricks, Natalia Briones, Rebecca F. Halperin, Salvatore Facista, Paul R. Heaton, Daruka Mahadevan, Suwon Kim
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cancers
Subjects:
breast cancer
her2
trastuzumab
gene signature
pd-1
survival outcome
tumor evolution
Online Access:https://www.mdpi.com/2072-6694/11/10/1566

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