BAM15 as a mitochondrial uncoupler: a promising therapeutic agent for diverse diseases
Subcellular organelles dysfunction is implicated in various diseases, including metabolic diseases, neurodegenerative diseases, cancer, and cardiovascular diseases. BAM15, a selective mitochondrial uncoupler, has emerged as a promising therapeutic agent due to its ability to enhance mitochondrial re...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1252141/full |
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| author | Guoji Xiong Guoji Xiong Kexin Zhang Kexin Zhang Yujie Ma Yixin Song Yixin Song Wenqiang Zhang Wenqiang Zhang Wenqiang Zhang Tongbing Qi Tongbing Qi Hongyan Qiu Hongyan Qiu Junfeng Shi Junfeng Shi Chengxia Kan Chengxia Kan Jingwen Zhang Jingwen Zhang Xiaodong Sun Xiaodong Sun |
| author_facet | Guoji Xiong Guoji Xiong Kexin Zhang Kexin Zhang Yujie Ma Yixin Song Yixin Song Wenqiang Zhang Wenqiang Zhang Wenqiang Zhang Tongbing Qi Tongbing Qi Hongyan Qiu Hongyan Qiu Junfeng Shi Junfeng Shi Chengxia Kan Chengxia Kan Jingwen Zhang Jingwen Zhang Xiaodong Sun Xiaodong Sun |
| author_sort | Guoji Xiong |
| collection | DOAJ |
| description | Subcellular organelles dysfunction is implicated in various diseases, including metabolic diseases, neurodegenerative diseases, cancer, and cardiovascular diseases. BAM15, a selective mitochondrial uncoupler, has emerged as a promising therapeutic agent due to its ability to enhance mitochondrial respiration and metabolic flexibility. By disrupting the coupling between electron transport and ATP synthesis, BAM15 dissipates the proton gradient, leading to increased mitochondrial respiration and energy expenditure. This review provides a comprehensive overview of BAM15, including its mechanism of action and potential therapeutic applications in diverse disease contexts. BAM15 has shown promise in obesity by increasing energy expenditure and reducing fat accumulation. In diabetes, it improves glycemic control and reverses insulin resistance. Additionally, BAM15 has potential in non-alcoholic fatty liver disease, sepsis, and cardiovascular diseases by mitigating oxidative stress, modulating inflammatory responses, and promoting cardioprotection. The safety profile of BAM15 is encouraging, with minimal adverse effects and remarkable tolerability. However, challenges such as its high lipophilicity and the need for alternative delivery methods need to be addressed. Further research is necessary to fully understand the therapeutic potential of BAM15 and optimize its application in clinical settings. |
| first_indexed | 2024-03-11T18:51:12Z |
| format | Article |
| id | doaj.art-e3298b5188624f889ea62cdd99188808 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-11T18:51:12Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-e3298b5188624f889ea62cdd991888082023-10-11T12:21:29ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-10-011410.3389/fendo.2023.12521411252141BAM15 as a mitochondrial uncoupler: a promising therapeutic agent for diverse diseasesGuoji Xiong0Guoji Xiong1Kexin Zhang2Kexin Zhang3Yujie Ma4Yixin Song5Yixin Song6Wenqiang Zhang7Wenqiang Zhang8Wenqiang Zhang9Tongbing Qi10Tongbing Qi11Hongyan Qiu12Hongyan Qiu13Junfeng Shi14Junfeng Shi15Chengxia Kan16Chengxia Kan17Jingwen Zhang18Jingwen Zhang19Xiaodong Sun20Xiaodong Sun21Department of Endocrinology and Metabolism, Affiliated Hospital of Weifang Medical University, School of Clinical Medicine, Weifang Medical University, Weifang, ChinaClinical Research Center, Affiliated Hospital of Weifang Medical University, Weifang, ChinaDepartment of Endocrinology and Metabolism, Affiliated Hospital of Weifang Medical University, School of Clinical Medicine, Weifang Medical University, Weifang, ChinaClinical Research Center, Affiliated Hospital of Weifang Medical University, Weifang, ChinaDepartment of Pathophysiology, School of Basic Medical Sciences, Weifang Medical University, Weifang, ChinaDepartment of Endocrinology and Metabolism, Affiliated Hospital of Weifang Medical University, School of Clinical Medicine, Weifang Medical University, Weifang, ChinaClinical Research Center, Affiliated Hospital of Weifang Medical University, Weifang, ChinaDepartment of Endocrinology and Metabolism, Affiliated Hospital of Weifang Medical University, School of Clinical Medicine, Weifang Medical University, Weifang, ChinaClinical Research Center, Affiliated Hospital of Weifang Medical University, Weifang, ChinaDepartment of Pathology, Affiliated Hospital of Weifang Medical University, Weifang, ChinaDepartment of Endocrinology and Metabolism, Affiliated Hospital of Weifang Medical University, School of Clinical Medicine, Weifang Medical University, Weifang, ChinaClinical Research Center, Affiliated Hospital of Weifang Medical University, Weifang, ChinaDepartment of Endocrinology and Metabolism, Affiliated Hospital of Weifang Medical University, School of Clinical Medicine, Weifang Medical University, Weifang, ChinaClinical Research Center, Affiliated Hospital of Weifang Medical University, Weifang, ChinaDepartment of Endocrinology and Metabolism, Affiliated Hospital of Weifang Medical University, School of Clinical Medicine, Weifang Medical University, Weifang, ChinaClinical Research Center, Affiliated Hospital of Weifang Medical University, Weifang, ChinaDepartment of Endocrinology and Metabolism, Affiliated Hospital of Weifang Medical University, School of Clinical Medicine, Weifang Medical University, Weifang, ChinaClinical Research Center, Affiliated Hospital of Weifang Medical University, Weifang, ChinaDepartment of Endocrinology and Metabolism, Affiliated Hospital of Weifang Medical University, School of Clinical Medicine, Weifang Medical University, Weifang, ChinaClinical Research Center, Affiliated Hospital of Weifang Medical University, Weifang, ChinaDepartment of Endocrinology and Metabolism, Affiliated Hospital of Weifang Medical University, School of Clinical Medicine, Weifang Medical University, Weifang, ChinaClinical Research Center, Affiliated Hospital of Weifang Medical University, Weifang, ChinaSubcellular organelles dysfunction is implicated in various diseases, including metabolic diseases, neurodegenerative diseases, cancer, and cardiovascular diseases. BAM15, a selective mitochondrial uncoupler, has emerged as a promising therapeutic agent due to its ability to enhance mitochondrial respiration and metabolic flexibility. By disrupting the coupling between electron transport and ATP synthesis, BAM15 dissipates the proton gradient, leading to increased mitochondrial respiration and energy expenditure. This review provides a comprehensive overview of BAM15, including its mechanism of action and potential therapeutic applications in diverse disease contexts. BAM15 has shown promise in obesity by increasing energy expenditure and reducing fat accumulation. In diabetes, it improves glycemic control and reverses insulin resistance. Additionally, BAM15 has potential in non-alcoholic fatty liver disease, sepsis, and cardiovascular diseases by mitigating oxidative stress, modulating inflammatory responses, and promoting cardioprotection. The safety profile of BAM15 is encouraging, with minimal adverse effects and remarkable tolerability. However, challenges such as its high lipophilicity and the need for alternative delivery methods need to be addressed. Further research is necessary to fully understand the therapeutic potential of BAM15 and optimize its application in clinical settings.https://www.frontiersin.org/articles/10.3389/fendo.2023.1252141/fullsubcellular organellesenergy homeostasismitochondrialmetabolic diseaseobesitydiabetes |
| spellingShingle | Guoji Xiong Guoji Xiong Kexin Zhang Kexin Zhang Yujie Ma Yixin Song Yixin Song Wenqiang Zhang Wenqiang Zhang Wenqiang Zhang Tongbing Qi Tongbing Qi Hongyan Qiu Hongyan Qiu Junfeng Shi Junfeng Shi Chengxia Kan Chengxia Kan Jingwen Zhang Jingwen Zhang Xiaodong Sun Xiaodong Sun BAM15 as a mitochondrial uncoupler: a promising therapeutic agent for diverse diseases Frontiers in Endocrinology subcellular organelles energy homeostasis mitochondrial metabolic disease obesity diabetes |
| title | BAM15 as a mitochondrial uncoupler: a promising therapeutic agent for diverse diseases |
| title_full | BAM15 as a mitochondrial uncoupler: a promising therapeutic agent for diverse diseases |
| title_fullStr | BAM15 as a mitochondrial uncoupler: a promising therapeutic agent for diverse diseases |
| title_full_unstemmed | BAM15 as a mitochondrial uncoupler: a promising therapeutic agent for diverse diseases |
| title_short | BAM15 as a mitochondrial uncoupler: a promising therapeutic agent for diverse diseases |
| title_sort | bam15 as a mitochondrial uncoupler a promising therapeutic agent for diverse diseases |
| topic | subcellular organelles energy homeostasis mitochondrial metabolic disease obesity diabetes |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1252141/full |
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