New insight into the role of autophagy in tumorigenesis
Autophagy plays an important role in maintaining cellular homeostasis. Its dysfunction can cause many diseases, including neurodegenerative diseases, metabolic diseases and cancer. The role of autophagy in carcinogenesis is complex, as it was shown to have pro-tumorigenic functions in some reports,...
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| Format: | Article |
| Language: | English |
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Shared Science Publishers OG
2017-12-01
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| Series: | Cell Stress |
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| Online Access: | http://www.cell-stress.com/researcharticles/new-insight-into-the-role-of-autophagy-in-tumorigenesis/ |
| _version_ | 1828451922508513280 |
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| author | Yongjun Tian Linya Wang Jing-hsiung James Ou |
| author_facet | Yongjun Tian Linya Wang Jing-hsiung James Ou |
| author_sort | Yongjun Tian |
| collection | DOAJ |
| description | Autophagy plays an important role in maintaining cellular homeostasis. Its dysfunction can cause many diseases, including neurodegenerative diseases, metabolic diseases and cancer. The role of autophagy in carcinogenesis is complex, as it was shown to have pro-tumorigenic functions in some reports, but anti-tumorigenic functions in others. By using mice with hepatocyte-specific knockout of Atg5, a gene essential for autophagy, we had previously demonstrated that impairing autophagy in hepatocytes would induce oxidative stress and DNA damage, followed by the initiation of hepatocarcinogenesis. Interestingly, these mice developed only benign tumors with no hepatocellular carcinoma (HCC), even after they were treated with the carcinogen diethylnitrosamine (DEN), which induced HCC in wild-type mice. Our recent studies indicated that the inability of mice to develop HCC when autophagy was impaired was at least partially due to the activation of the tumor suppressor TP53, which suppressed the expression of NANOG, a transcription factor critical for the self-renewal and the maintenance of cancer stem cells (CSCs). |
| first_indexed | 2024-12-10T23:44:44Z |
| format | Article |
| id | doaj.art-e32a3747d1ea4e46a640921eff6ebdcb |
| institution | Directory Open Access Journal |
| issn | 2523-0204 |
| language | English |
| last_indexed | 2024-12-10T23:44:44Z |
| publishDate | 2017-12-01 |
| publisher | Shared Science Publishers OG |
| record_format | Article |
| series | Cell Stress |
| spelling | doaj.art-e32a3747d1ea4e46a640921eff6ebdcb2022-12-22T01:28:57ZengShared Science Publishers OGCell Stress2523-02042017-12-011313613810.15698/cst2017.12.116New insight into the role of autophagy in tumorigenesisYongjun Tian0Linya Wang1Jing-hsiung James Ou2Department of Hematology, Quest Diagnostics Inc, West Hills, Los Angeles, California, USA.Department of Molecular Microbiology and Immunology, University of Southern California Keck School of Medicine, Los Angeles, California, USA.Department of Molecular Microbiology and Immunology, University of Southern California Keck School of Medicine, Los Angeles, California, USA.Autophagy plays an important role in maintaining cellular homeostasis. Its dysfunction can cause many diseases, including neurodegenerative diseases, metabolic diseases and cancer. The role of autophagy in carcinogenesis is complex, as it was shown to have pro-tumorigenic functions in some reports, but anti-tumorigenic functions in others. By using mice with hepatocyte-specific knockout of Atg5, a gene essential for autophagy, we had previously demonstrated that impairing autophagy in hepatocytes would induce oxidative stress and DNA damage, followed by the initiation of hepatocarcinogenesis. Interestingly, these mice developed only benign tumors with no hepatocellular carcinoma (HCC), even after they were treated with the carcinogen diethylnitrosamine (DEN), which induced HCC in wild-type mice. Our recent studies indicated that the inability of mice to develop HCC when autophagy was impaired was at least partially due to the activation of the tumor suppressor TP53, which suppressed the expression of NANOG, a transcription factor critical for the self-renewal and the maintenance of cancer stem cells (CSCs).http://www.cell-stress.com/researcharticles/new-insight-into-the-role-of-autophagy-in-tumorigenesis/autophagymitophagyhepatic cancer stem cellshepatocarcinogenesisp53PINK1 |
| spellingShingle | Yongjun Tian Linya Wang Jing-hsiung James Ou New insight into the role of autophagy in tumorigenesis Cell Stress autophagy mitophagy hepatic cancer stem cells hepatocarcinogenesis p53 PINK1 |
| title | New insight into the role of autophagy in tumorigenesis |
| title_full | New insight into the role of autophagy in tumorigenesis |
| title_fullStr | New insight into the role of autophagy in tumorigenesis |
| title_full_unstemmed | New insight into the role of autophagy in tumorigenesis |
| title_short | New insight into the role of autophagy in tumorigenesis |
| title_sort | new insight into the role of autophagy in tumorigenesis |
| topic | autophagy mitophagy hepatic cancer stem cells hepatocarcinogenesis p53 PINK1 |
| url | http://www.cell-stress.com/researcharticles/new-insight-into-the-role-of-autophagy-in-tumorigenesis/ |
| work_keys_str_mv | AT yongjuntian newinsightintotheroleofautophagyintumorigenesis AT linyawang newinsightintotheroleofautophagyintumorigenesis AT jinghsiungjamesou newinsightintotheroleofautophagyintumorigenesis |