N-Terminal Pro-B Type Natriuretic Peptide as a Predictive Biomarker of Bronchopulmonary Dysplasia or Death Due to Bronchopulmonary Dysplasia in Preterm Neonates: A Systematic Review and Meta-Analysis
Background: Emerging evidence suggests the clinical utility of N terminal pro B type natriuretic peptide (NT-proBNP) in multiple cardiac and pulmonary abnormalities both in adult and pediatric populations. To date, however, there is no consensus regarding its efficacy for the prediction and severity...
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| Format: | Article |
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MDPI AG
2023-08-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/13/9/1287 |
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| author | Kalliopi Rodolaki Vasilios Pergialiotis Ioakeim Sapantzoglou Marianna Theodora Panagiotis Antsaklis Kalliopi Pappa Georgios Daskalakis Aggeliki Papapanagiotou |
| author_facet | Kalliopi Rodolaki Vasilios Pergialiotis Ioakeim Sapantzoglou Marianna Theodora Panagiotis Antsaklis Kalliopi Pappa Georgios Daskalakis Aggeliki Papapanagiotou |
| author_sort | Kalliopi Rodolaki |
| collection | DOAJ |
| description | Background: Emerging evidence suggests the clinical utility of N terminal pro B type natriuretic peptide (NT-proBNP) in multiple cardiac and pulmonary abnormalities both in adult and pediatric populations. To date, however, there is no consensus regarding its efficacy for the prediction and severity of bronchopulmonary dysplasia in premature neonates. The objective of the present meta-analysis was to determine differences in NT-proBNP among neonates that develop BPD or die from BPD and to evaluate if there is relative information on the diagnostic accuracy of the method. Methods: We conducted a systematic search according to the PRISMA guidelines and looked into Medline (1966–2023), Scopus (2004–2023), Clinicaltrials.gov (2008–2023), EMBASE (1980–2023), Cochrane Central Register of Controlled Trials CENTRAL (1999–2022) and Google Scholar (2004–2023) together with the reference lists from included studies. The potential risk of bias encountered in our study was evaluated using the QUADAS -2 tool. Finally, a total of 9 studies met the eligibility criteria, comprising 1319 newborns, from which 397 developed BPD and 922 were unaffected controls. Results: The results retrieved from our meta-analysis showed that newborns suffering from BPD had notably elevated NT-proBNP levels after birth when compared with healthy neonates (SMD 2.57, 95% CI 0.41, 4.72). The summary effect of the AUC meta-analysis showed that NT-proBNP was very accurate in detecting neonates at risk of developing severe BPD or dying from the disease (AUC −0.16, 95% CI −0.23, −0.08). No studies reported data relevant to the sensitivity and/or specificity of the method in diagnosing BPD. Conclusion: Serum NT-proBNP levels represent a potential future biomarker with great diagnostic validity for the prediction of BPD complicating preterm deliveries. The limited amount of studies included and the significant variations in cutoff values and timing of measurement still restrict the application of NT-proBNP as an established clinical biomarker for BPD. The design of larger prospective studies will provide a more representative number of participants and will address the discrepancies in existing literature. |
| first_indexed | 2024-03-10T22:34:40Z |
| format | Article |
| id | doaj.art-e32cc5550a074faca192340d89025f0a |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-10T22:34:40Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-e32cc5550a074faca192340d89025f0a2023-11-19T11:30:09ZengMDPI AGJournal of Personalized Medicine2075-44262023-08-01139128710.3390/jpm13091287N-Terminal Pro-B Type Natriuretic Peptide as a Predictive Biomarker of Bronchopulmonary Dysplasia or Death Due to Bronchopulmonary Dysplasia in Preterm Neonates: A Systematic Review and Meta-AnalysisKalliopi Rodolaki0Vasilios Pergialiotis1Ioakeim Sapantzoglou2Marianna Theodora3Panagiotis Antsaklis4Kalliopi Pappa5Georgios Daskalakis6Aggeliki Papapanagiotou71st Department of Pediatrics, National and Kapodistrian University of Athens, Aghia Sophia Children’s Hospital, 11527 Athens, Greece1st Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece1st Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece1st Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece1st Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece1st Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece1st Department of Obstetrics and Gynecology, Alexandra Hospital, National and Kapodistrian University of Athens, 11527 Athens, GreeceDepartment of Biological Chemistry, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, GreeceBackground: Emerging evidence suggests the clinical utility of N terminal pro B type natriuretic peptide (NT-proBNP) in multiple cardiac and pulmonary abnormalities both in adult and pediatric populations. To date, however, there is no consensus regarding its efficacy for the prediction and severity of bronchopulmonary dysplasia in premature neonates. The objective of the present meta-analysis was to determine differences in NT-proBNP among neonates that develop BPD or die from BPD and to evaluate if there is relative information on the diagnostic accuracy of the method. Methods: We conducted a systematic search according to the PRISMA guidelines and looked into Medline (1966–2023), Scopus (2004–2023), Clinicaltrials.gov (2008–2023), EMBASE (1980–2023), Cochrane Central Register of Controlled Trials CENTRAL (1999–2022) and Google Scholar (2004–2023) together with the reference lists from included studies. The potential risk of bias encountered in our study was evaluated using the QUADAS -2 tool. Finally, a total of 9 studies met the eligibility criteria, comprising 1319 newborns, from which 397 developed BPD and 922 were unaffected controls. Results: The results retrieved from our meta-analysis showed that newborns suffering from BPD had notably elevated NT-proBNP levels after birth when compared with healthy neonates (SMD 2.57, 95% CI 0.41, 4.72). The summary effect of the AUC meta-analysis showed that NT-proBNP was very accurate in detecting neonates at risk of developing severe BPD or dying from the disease (AUC −0.16, 95% CI −0.23, −0.08). No studies reported data relevant to the sensitivity and/or specificity of the method in diagnosing BPD. Conclusion: Serum NT-proBNP levels represent a potential future biomarker with great diagnostic validity for the prediction of BPD complicating preterm deliveries. The limited amount of studies included and the significant variations in cutoff values and timing of measurement still restrict the application of NT-proBNP as an established clinical biomarker for BPD. The design of larger prospective studies will provide a more representative number of participants and will address the discrepancies in existing literature.https://www.mdpi.com/2075-4426/13/9/1287NT-proBNPbronchopulmonary dysplasiapreterm birthpremature neonatemeta-analysis |
| spellingShingle | Kalliopi Rodolaki Vasilios Pergialiotis Ioakeim Sapantzoglou Marianna Theodora Panagiotis Antsaklis Kalliopi Pappa Georgios Daskalakis Aggeliki Papapanagiotou N-Terminal Pro-B Type Natriuretic Peptide as a Predictive Biomarker of Bronchopulmonary Dysplasia or Death Due to Bronchopulmonary Dysplasia in Preterm Neonates: A Systematic Review and Meta-Analysis Journal of Personalized Medicine NT-proBNP bronchopulmonary dysplasia preterm birth premature neonate meta-analysis |
| title | N-Terminal Pro-B Type Natriuretic Peptide as a Predictive Biomarker of Bronchopulmonary Dysplasia or Death Due to Bronchopulmonary Dysplasia in Preterm Neonates: A Systematic Review and Meta-Analysis |
| title_full | N-Terminal Pro-B Type Natriuretic Peptide as a Predictive Biomarker of Bronchopulmonary Dysplasia or Death Due to Bronchopulmonary Dysplasia in Preterm Neonates: A Systematic Review and Meta-Analysis |
| title_fullStr | N-Terminal Pro-B Type Natriuretic Peptide as a Predictive Biomarker of Bronchopulmonary Dysplasia or Death Due to Bronchopulmonary Dysplasia in Preterm Neonates: A Systematic Review and Meta-Analysis |
| title_full_unstemmed | N-Terminal Pro-B Type Natriuretic Peptide as a Predictive Biomarker of Bronchopulmonary Dysplasia or Death Due to Bronchopulmonary Dysplasia in Preterm Neonates: A Systematic Review and Meta-Analysis |
| title_short | N-Terminal Pro-B Type Natriuretic Peptide as a Predictive Biomarker of Bronchopulmonary Dysplasia or Death Due to Bronchopulmonary Dysplasia in Preterm Neonates: A Systematic Review and Meta-Analysis |
| title_sort | n terminal pro b type natriuretic peptide as a predictive biomarker of bronchopulmonary dysplasia or death due to bronchopulmonary dysplasia in preterm neonates a systematic review and meta analysis |
| topic | NT-proBNP bronchopulmonary dysplasia preterm birth premature neonate meta-analysis |
| url | https://www.mdpi.com/2075-4426/13/9/1287 |
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