A New Preoperative Scoring System for Predicting Aggressiveness of Non-Functioning Pancreatic Neuroendocrine Neoplasms
The management of non-functioning pancreatic neuroendocrine neoplasms (NF-PanNENs) is still controversial. This study aimed to develop a new scoring system for treatment decisions at initial diagnosis based on the identification of the predictive factors for aggressive NF-PanNENs. Seventy-seven pati...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/2/397 |
| _version_ | 1797481249287176192 |
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| author | Tetsuya Takikawa Kazuhiro Kikuta Shin Hamada Kiyoshi Kume Shin Miura Naoki Yoshida Yu Tanaka Ryotaro Matsumoto Mio Ikeda Fumiya Kataoka Akira Sasaki Hidehiro Hayashi Waku Hatta Yohei Ogata Kei Nakagawa Michiaki Unno Atsushi Masamune |
| author_facet | Tetsuya Takikawa Kazuhiro Kikuta Shin Hamada Kiyoshi Kume Shin Miura Naoki Yoshida Yu Tanaka Ryotaro Matsumoto Mio Ikeda Fumiya Kataoka Akira Sasaki Hidehiro Hayashi Waku Hatta Yohei Ogata Kei Nakagawa Michiaki Unno Atsushi Masamune |
| author_sort | Tetsuya Takikawa |
| collection | DOAJ |
| description | The management of non-functioning pancreatic neuroendocrine neoplasms (NF-PanNENs) is still controversial. This study aimed to develop a new scoring system for treatment decisions at initial diagnosis based on the identification of the predictive factors for aggressive NF-PanNENs. Seventy-seven patients who had been pathologically diagnosed with NF-PanNENs were enrolled. We retrospectively reviewed 13 variables that could be assessed preoperatively. Univariate and multivariate stepwise logistic regression analyses were performed to identify factors for the aggressiveness of NF-PanNENs, and a scoring system was developed by assigning weighted points proportional to their β regression coefficient. Tumor size > 20 mm on contrast-enhanced computed tomography, tumor non-vascularity, and Ki-67 labeling index ≥5% on endoscopic ultrasound-guided fine-needle aspiration specimens were identified as independent factors for predicting the aggressiveness of NF-PanNENs. The new scoring system, developed using the identified factors, had an excellent discrimination ability, with area under the curve of 0.92 (95% CI, 0.85–0.99), and good calibration (<i>p</i> = 0.72, Hosmer-Lemeshow test). Ten-year overall survival rates in low-risk (0 point), intermediate-risk (1 to 2 points), and high-risk (3 to 4 points) groups were 100%, 90.9%, and 24.3%, respectively. This new scoring system would be useful for treatment decisions and prognostic prediction at initial diagnosis. |
| first_indexed | 2024-03-09T22:11:48Z |
| format | Article |
| id | doaj.art-e32e2354b4d94d4a8fcd7d55209d66e1 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T22:11:48Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-e32e2354b4d94d4a8fcd7d55209d66e12023-11-23T19:31:22ZengMDPI AGDiagnostics2075-44182022-02-0112239710.3390/diagnostics12020397A New Preoperative Scoring System for Predicting Aggressiveness of Non-Functioning Pancreatic Neuroendocrine NeoplasmsTetsuya Takikawa0Kazuhiro Kikuta1Shin Hamada2Kiyoshi Kume3Shin Miura4Naoki Yoshida5Yu Tanaka6Ryotaro Matsumoto7Mio Ikeda8Fumiya Kataoka9Akira Sasaki10Hidehiro Hayashi11Waku Hatta12Yohei Ogata13Kei Nakagawa14Michiaki Unno15Atsushi Masamune16Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980-8574, JapanDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980-8574, JapanDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980-8574, JapanDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980-8574, JapanDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980-8574, JapanDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980-8574, JapanDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980-8574, JapanDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980-8574, JapanDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980-8574, JapanDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980-8574, JapanDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980-8574, JapanDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980-8574, JapanDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980-8574, JapanDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980-8574, JapanDepartment of Surgery, Graduate School of Medicine, Tohoku University, Sendai 980-8574, JapanDepartment of Surgery, Graduate School of Medicine, Tohoku University, Sendai 980-8574, JapanDivision of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai 980-8574, JapanThe management of non-functioning pancreatic neuroendocrine neoplasms (NF-PanNENs) is still controversial. This study aimed to develop a new scoring system for treatment decisions at initial diagnosis based on the identification of the predictive factors for aggressive NF-PanNENs. Seventy-seven patients who had been pathologically diagnosed with NF-PanNENs were enrolled. We retrospectively reviewed 13 variables that could be assessed preoperatively. Univariate and multivariate stepwise logistic regression analyses were performed to identify factors for the aggressiveness of NF-PanNENs, and a scoring system was developed by assigning weighted points proportional to their β regression coefficient. Tumor size > 20 mm on contrast-enhanced computed tomography, tumor non-vascularity, and Ki-67 labeling index ≥5% on endoscopic ultrasound-guided fine-needle aspiration specimens were identified as independent factors for predicting the aggressiveness of NF-PanNENs. The new scoring system, developed using the identified factors, had an excellent discrimination ability, with area under the curve of 0.92 (95% CI, 0.85–0.99), and good calibration (<i>p</i> = 0.72, Hosmer-Lemeshow test). Ten-year overall survival rates in low-risk (0 point), intermediate-risk (1 to 2 points), and high-risk (3 to 4 points) groups were 100%, 90.9%, and 24.3%, respectively. This new scoring system would be useful for treatment decisions and prognostic prediction at initial diagnosis.https://www.mdpi.com/2075-4418/12/2/397endoscopic ultrasound-guided fine-needle aspirationpancreatic cancerpancreatic neuroendocrine neoplasmprediction modelKi-67 |
| spellingShingle | Tetsuya Takikawa Kazuhiro Kikuta Shin Hamada Kiyoshi Kume Shin Miura Naoki Yoshida Yu Tanaka Ryotaro Matsumoto Mio Ikeda Fumiya Kataoka Akira Sasaki Hidehiro Hayashi Waku Hatta Yohei Ogata Kei Nakagawa Michiaki Unno Atsushi Masamune A New Preoperative Scoring System for Predicting Aggressiveness of Non-Functioning Pancreatic Neuroendocrine Neoplasms Diagnostics endoscopic ultrasound-guided fine-needle aspiration pancreatic cancer pancreatic neuroendocrine neoplasm prediction model Ki-67 |
| title | A New Preoperative Scoring System for Predicting Aggressiveness of Non-Functioning Pancreatic Neuroendocrine Neoplasms |
| title_full | A New Preoperative Scoring System for Predicting Aggressiveness of Non-Functioning Pancreatic Neuroendocrine Neoplasms |
| title_fullStr | A New Preoperative Scoring System for Predicting Aggressiveness of Non-Functioning Pancreatic Neuroendocrine Neoplasms |
| title_full_unstemmed | A New Preoperative Scoring System for Predicting Aggressiveness of Non-Functioning Pancreatic Neuroendocrine Neoplasms |
| title_short | A New Preoperative Scoring System for Predicting Aggressiveness of Non-Functioning Pancreatic Neuroendocrine Neoplasms |
| title_sort | new preoperative scoring system for predicting aggressiveness of non functioning pancreatic neuroendocrine neoplasms |
| topic | endoscopic ultrasound-guided fine-needle aspiration pancreatic cancer pancreatic neuroendocrine neoplasm prediction model Ki-67 |
| url | https://www.mdpi.com/2075-4418/12/2/397 |
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