Circulating Tumour DNAs and Non-Coding RNAs as Liquid Biopsies for the Management of Colorectal Cancer Patients
Circulating tumour DNAs and non-coding RNAs present in body fluids have been under investigation as tools for cancer diagnosis, disease monitoring, and prognosis for many years. These so-called liquid biopsies offer the opportunity to obtain information about the molecular make-up of a cancer in a m...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-07-01
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| Series: | Gastrointestinal Disorders |
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| Online Access: | https://www.mdpi.com/2624-5647/2/3/22 |
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| author | Andrea Lampis Michele Ghidini Margherita Ratti Milko B. Mirchev Ali Fuat Okuducu Nicola Valeri Jens Claus Hahne |
| author_facet | Andrea Lampis Michele Ghidini Margherita Ratti Milko B. Mirchev Ali Fuat Okuducu Nicola Valeri Jens Claus Hahne |
| author_sort | Andrea Lampis |
| collection | DOAJ |
| description | Circulating tumour DNAs and non-coding RNAs present in body fluids have been under investigation as tools for cancer diagnosis, disease monitoring, and prognosis for many years. These so-called liquid biopsies offer the opportunity to obtain information about the molecular make-up of a cancer in a minimal invasive way and offer the possibility to implement theranostics for precision oncology. Furthermore, liquid biopsies could overcome the limitations of tissue biopsies in capturing the complexity of tumour heterogeneity within the primary cancer and among different metastatic sites. Liquid biopsies may also be implemented to detect early tumour formation or to monitor cancer relapse of response to therapy with greater sensitivity compared with the currently available protein-based blood biomarkers. Most colorectal cancers are often diagnosed at late stages and have a high mortality rate. Hence, biomolecules as nucleic acids present in liquid biopsies might have prognostic potential and could serve as predictive biomarkers for chemotherapeutic regimens. This review will focus on the role of circulating tumour DNAs and non-coding RNAs as diagnostic, prognostic, and predictive biomarkers in the context of colorectal cancer. |
| first_indexed | 2024-03-10T18:17:24Z |
| format | Article |
| id | doaj.art-e32fa9381af545cab13012afdc8ebdfd |
| institution | Directory Open Access Journal |
| issn | 2624-5647 |
| language | English |
| last_indexed | 2024-03-10T18:17:24Z |
| publishDate | 2020-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gastrointestinal Disorders |
| spelling | doaj.art-e32fa9381af545cab13012afdc8ebdfd2023-11-20T07:37:33ZengMDPI AGGastrointestinal Disorders2624-56472020-07-012321223510.3390/gidisord2030022Circulating Tumour DNAs and Non-Coding RNAs as Liquid Biopsies for the Management of Colorectal Cancer PatientsAndrea Lampis0Michele Ghidini1Margherita Ratti2Milko B. Mirchev3Ali Fuat Okuducu4Nicola Valeri5Jens Claus Hahne6Division of Molecular Pathology, The Institute of Cancer Research, London SM2 5NG, UKDivision of Medical Oncology, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, 20122 Milan, ItalyDivision of Molecular Pathology, The Institute of Cancer Research, London SM2 5NG, UKClinic of Gastroenterology, Medical University, 9002 Varna, BulgariaPathologie Länggasse, 3001 Bern, SwitzerlandDivision of Molecular Pathology, The Institute of Cancer Research, London SM2 5NG, UKDivision of Molecular Pathology, The Institute of Cancer Research, London SM2 5NG, UKCirculating tumour DNAs and non-coding RNAs present in body fluids have been under investigation as tools for cancer diagnosis, disease monitoring, and prognosis for many years. These so-called liquid biopsies offer the opportunity to obtain information about the molecular make-up of a cancer in a minimal invasive way and offer the possibility to implement theranostics for precision oncology. Furthermore, liquid biopsies could overcome the limitations of tissue biopsies in capturing the complexity of tumour heterogeneity within the primary cancer and among different metastatic sites. Liquid biopsies may also be implemented to detect early tumour formation or to monitor cancer relapse of response to therapy with greater sensitivity compared with the currently available protein-based blood biomarkers. Most colorectal cancers are often diagnosed at late stages and have a high mortality rate. Hence, biomolecules as nucleic acids present in liquid biopsies might have prognostic potential and could serve as predictive biomarkers for chemotherapeutic regimens. This review will focus on the role of circulating tumour DNAs and non-coding RNAs as diagnostic, prognostic, and predictive biomarkers in the context of colorectal cancer.https://www.mdpi.com/2624-5647/2/3/22colorectal cancerliquid biopsymicroRNAcircularRNAlong non-coding RNAcirculating cell-free tumour DNA |
| spellingShingle | Andrea Lampis Michele Ghidini Margherita Ratti Milko B. Mirchev Ali Fuat Okuducu Nicola Valeri Jens Claus Hahne Circulating Tumour DNAs and Non-Coding RNAs as Liquid Biopsies for the Management of Colorectal Cancer Patients Gastrointestinal Disorders colorectal cancer liquid biopsy microRNA circularRNA long non-coding RNA circulating cell-free tumour DNA |
| title | Circulating Tumour DNAs and Non-Coding RNAs as Liquid Biopsies for the Management of Colorectal Cancer Patients |
| title_full | Circulating Tumour DNAs and Non-Coding RNAs as Liquid Biopsies for the Management of Colorectal Cancer Patients |
| title_fullStr | Circulating Tumour DNAs and Non-Coding RNAs as Liquid Biopsies for the Management of Colorectal Cancer Patients |
| title_full_unstemmed | Circulating Tumour DNAs and Non-Coding RNAs as Liquid Biopsies for the Management of Colorectal Cancer Patients |
| title_short | Circulating Tumour DNAs and Non-Coding RNAs as Liquid Biopsies for the Management of Colorectal Cancer Patients |
| title_sort | circulating tumour dnas and non coding rnas as liquid biopsies for the management of colorectal cancer patients |
| topic | colorectal cancer liquid biopsy microRNA circularRNA long non-coding RNA circulating cell-free tumour DNA |
| url | https://www.mdpi.com/2624-5647/2/3/22 |
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