Arsenic trioxide-induced apoptosis contributes to suppression of viral reservoir in SIV-infected rhesus macaques

Arsenic trioxide-induced apoptosis contributes to suppression of viral reservoir in SIV-infected rhesus macaques

ABSTRACT Latent viral reservoir is recognized as the major obstacle to achieving a functional cure for HIV infection. We previously reported that arsenic trioxide (As2O3) combined with antiretroviral therapy (ART) can reactivate the viral reservoir and delay viral rebound after ART interruption in c...

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Bibliographic Details
Main Authors: Yizi He, Chunxiu Wu, Zijian Liu, Yudi Zhang, Fengling Feng, Zihan Lin, Congcong Wang, Qing Yang, Ziyu Wen, Yichu Liu, Fan Zhang, Yanqin Lin, Hao Zhang, Linbing Qu, Linghua Li, Weiping Cai, Caijun Sun, Ling Chen, Pingchao Li
Format: Article
Language:English
Published: American Society for Microbiology 2023-10-01
Series:Microbiology Spectrum
Subjects:
arsenic trioxide
HIV/SIV
latent viral reservoir
rhesus macaques
apoptosis
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00525-23

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