Using Multiparametric Cardiac Magnetic Resonance to Phenotype and Differentiate Biopsy-Proven Chronic from Healed Myocarditis and Dilated Cardiomyopathy
<b>(1) Objectives</b>: To discriminate biopsy-proven myocarditis (chronic vs. healed myocarditis) and to differentiate from dilated cardiomyopathy (DCM) using cardiac magnetic resonance (CMR). <b>(2) Methods</b>: A total of 259 consecutive patients (age 51 ± 15 years; 28% fem...
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MDPI AG
2022-08-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/17/5047 |
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| author | Patrick Krumm Jan M. Brendel Karin Klingel Karin A. L. Müller Jens Kübler Christoph Gräni Meinrad Gawaz Konstantin Nikolaou Simon Greulich |
| author_facet | Patrick Krumm Jan M. Brendel Karin Klingel Karin A. L. Müller Jens Kübler Christoph Gräni Meinrad Gawaz Konstantin Nikolaou Simon Greulich |
| author_sort | Patrick Krumm |
| collection | DOAJ |
| description | <b>(1) Objectives</b>: To discriminate biopsy-proven myocarditis (chronic vs. healed myocarditis) and to differentiate from dilated cardiomyopathy (DCM) using cardiac magnetic resonance (CMR). <b>(2) Methods</b>: A total of 259 consecutive patients (age 51 ± 15 years; 28% female) who underwent both endomyocardial biopsy (EMB) and CMR in the years 2008–2021 were evaluated. According to right-ventricular EMB results, patients were divided into either chronic (<i>n</i> = 130, 50%) or healed lymphocytic myocarditis (<i>n</i> = 60, 23%) or DCM (<i>n</i> = 69, 27%). The CMR protocol included functional, strain, and late gadolinium enhancement (LGE) imaging, T2w imaging, and T2 mapping. <b>(3) Results</b>: Left-ventricular ejection fraction (LV-EF) was higher, and the indexed end-diastolic volume (EDV) was lower in myocarditis patients (chronic: 42%, median 96 mL/m²; healed: 49%, 86 mL/m²) compared to the DCM patients (31%, 120 mL/m²), <i>p</i> < 0.0001. Strain analysis demonstrated lower contractility in DCM patients vs. myocarditis patients, <i>p</i> < 0.0001. Myocarditis patients demonstrated a higher LGE prevalence (68% chronic; 59% healed) than the DCM patients (45%), <i>p</i> = 0.01. Chronic myocarditis patients showed a higher myocardial edema prevalence and ratio (59%, median 1.3) than healed myocarditis (23%, 1.3) and DCM patients (13%, 1.0), <i>p</i> < 0.0001. T2 mapping revealed elevated values more frequently in chronic (90%) than in healed (21%) myocarditis and DCM (23%), <i>p</i> < 0.0001. T2 mapping yielded an AUC of 0.89 (sensitivity 90%, specificity 76%) in the discrimination of chronic from healed myocarditis and an AUC of 0.92 (sensitivity 86%, specificity 91%) in the discrimination of chronic myocarditis from DCM, both <i>p</i> < 0.0001. <b>(4) Conclusions</b>: Multiparametric CMR imaging, including functional parameters, LGE and T2 mapping, may allow differentiation of chronic from healed myocarditis and DCM and therefore help to optimize patient management in this clinical setting. |
| first_indexed | 2024-03-10T01:39:49Z |
| format | Article |
| id | doaj.art-e3305508ce4345139a6c536e9dd90e21 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T01:39:49Z |
| publishDate | 2022-08-01 |
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| series | Journal of Clinical Medicine |
| spelling | doaj.art-e3305508ce4345139a6c536e9dd90e212023-11-23T13:26:43ZengMDPI AGJournal of Clinical Medicine2077-03832022-08-011117504710.3390/jcm11175047Using Multiparametric Cardiac Magnetic Resonance to Phenotype and Differentiate Biopsy-Proven Chronic from Healed Myocarditis and Dilated CardiomyopathyPatrick Krumm0Jan M. Brendel1Karin Klingel2Karin A. L. Müller3Jens Kübler4Christoph Gräni5Meinrad Gawaz6Konstantin Nikolaou7Simon Greulich8Department of Radiology, Diagnostic and Interventional Radiology, University of Tübingen, Hoppe-Seyler-Straße 3, 72076 Tübingen, GermanyDepartment of Radiology, Diagnostic and Interventional Radiology, University of Tübingen, Hoppe-Seyler-Straße 3, 72076 Tübingen, GermanyCardiopathology, Institute for Pathology and Neuropathology, University of Tübingen, Liebermeisterstraße 8, 72076 Tübingen, GermanyDepartment of Internal Medicine III, Cardiology and Angiology, University of Tübingen, Otfried-Müller-Straße 10, 72076 Tübingen, GermanyDepartment of Radiology, Diagnostic and Interventional Radiology, University of Tübingen, Hoppe-Seyler-Straße 3, 72076 Tübingen, GermanyDepartment of Cardiology and Angiology, University of Bern, Freiburgstrasse 18, CH-3010 Bern, SwitzerlandDepartment of Internal Medicine III, Cardiology and Angiology, University of Tübingen, Otfried-Müller-Straße 10, 72076 Tübingen, GermanyDepartment of Radiology, Diagnostic and Interventional Radiology, University of Tübingen, Hoppe-Seyler-Straße 3, 72076 Tübingen, GermanyDepartment of Internal Medicine III, Cardiology and Angiology, University of Tübingen, Otfried-Müller-Straße 10, 72076 Tübingen, Germany<b>(1) Objectives</b>: To discriminate biopsy-proven myocarditis (chronic vs. healed myocarditis) and to differentiate from dilated cardiomyopathy (DCM) using cardiac magnetic resonance (CMR). <b>(2) Methods</b>: A total of 259 consecutive patients (age 51 ± 15 years; 28% female) who underwent both endomyocardial biopsy (EMB) and CMR in the years 2008–2021 were evaluated. According to right-ventricular EMB results, patients were divided into either chronic (<i>n</i> = 130, 50%) or healed lymphocytic myocarditis (<i>n</i> = 60, 23%) or DCM (<i>n</i> = 69, 27%). The CMR protocol included functional, strain, and late gadolinium enhancement (LGE) imaging, T2w imaging, and T2 mapping. <b>(3) Results</b>: Left-ventricular ejection fraction (LV-EF) was higher, and the indexed end-diastolic volume (EDV) was lower in myocarditis patients (chronic: 42%, median 96 mL/m²; healed: 49%, 86 mL/m²) compared to the DCM patients (31%, 120 mL/m²), <i>p</i> < 0.0001. Strain analysis demonstrated lower contractility in DCM patients vs. myocarditis patients, <i>p</i> < 0.0001. Myocarditis patients demonstrated a higher LGE prevalence (68% chronic; 59% healed) than the DCM patients (45%), <i>p</i> = 0.01. Chronic myocarditis patients showed a higher myocardial edema prevalence and ratio (59%, median 1.3) than healed myocarditis (23%, 1.3) and DCM patients (13%, 1.0), <i>p</i> < 0.0001. T2 mapping revealed elevated values more frequently in chronic (90%) than in healed (21%) myocarditis and DCM (23%), <i>p</i> < 0.0001. T2 mapping yielded an AUC of 0.89 (sensitivity 90%, specificity 76%) in the discrimination of chronic from healed myocarditis and an AUC of 0.92 (sensitivity 86%, specificity 91%) in the discrimination of chronic myocarditis from DCM, both <i>p</i> < 0.0001. <b>(4) Conclusions</b>: Multiparametric CMR imaging, including functional parameters, LGE and T2 mapping, may allow differentiation of chronic from healed myocarditis and DCM and therefore help to optimize patient management in this clinical setting.https://www.mdpi.com/2077-0383/11/17/5047myocarditisdilated cardiomyopathyDCMmagnetic resonance imagingCMRLGE |
| spellingShingle | Patrick Krumm Jan M. Brendel Karin Klingel Karin A. L. Müller Jens Kübler Christoph Gräni Meinrad Gawaz Konstantin Nikolaou Simon Greulich Using Multiparametric Cardiac Magnetic Resonance to Phenotype and Differentiate Biopsy-Proven Chronic from Healed Myocarditis and Dilated Cardiomyopathy Journal of Clinical Medicine myocarditis dilated cardiomyopathy DCM magnetic resonance imaging CMR LGE |
| title | Using Multiparametric Cardiac Magnetic Resonance to Phenotype and Differentiate Biopsy-Proven Chronic from Healed Myocarditis and Dilated Cardiomyopathy |
| title_full | Using Multiparametric Cardiac Magnetic Resonance to Phenotype and Differentiate Biopsy-Proven Chronic from Healed Myocarditis and Dilated Cardiomyopathy |
| title_fullStr | Using Multiparametric Cardiac Magnetic Resonance to Phenotype and Differentiate Biopsy-Proven Chronic from Healed Myocarditis and Dilated Cardiomyopathy |
| title_full_unstemmed | Using Multiparametric Cardiac Magnetic Resonance to Phenotype and Differentiate Biopsy-Proven Chronic from Healed Myocarditis and Dilated Cardiomyopathy |
| title_short | Using Multiparametric Cardiac Magnetic Resonance to Phenotype and Differentiate Biopsy-Proven Chronic from Healed Myocarditis and Dilated Cardiomyopathy |
| title_sort | using multiparametric cardiac magnetic resonance to phenotype and differentiate biopsy proven chronic from healed myocarditis and dilated cardiomyopathy |
| topic | myocarditis dilated cardiomyopathy DCM magnetic resonance imaging CMR LGE |
| url | https://www.mdpi.com/2077-0383/11/17/5047 |
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