Developmental origins of adult diseases
The occurrence and mechanisms of developmental adult diseases have gradually attracted attention in recent years. Exposure of gametes and embryos to adverse environments, especially during plastic development, can alter the expression of certain tissue-specific genes, leading to increased susceptibi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2022-10-01
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| Series: | Medical Review |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/mr-2022-0027 |
| _version_ | 1797848676063772672 |
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| author | Mo Jiaying Liu Xuanqi Huang Yutong He Renke Zhang Yu Huang Hefeng |
| author_facet | Mo Jiaying Liu Xuanqi Huang Yutong He Renke Zhang Yu Huang Hefeng |
| author_sort | Mo Jiaying |
| collection | DOAJ |
| description | The occurrence and mechanisms of developmental adult diseases have gradually attracted attention in recent years. Exposure of gametes and embryos to adverse environments, especially during plastic development, can alter the expression of certain tissue-specific genes, leading to increased susceptibility to certain diseases in adulthood, such as diabetes, cardiovascular disease, neuropsychiatric, and reproductive system diseases, etc. The occurrence of chronic disease in adulthood is partly due to genetic factors, and the remaining risk is partly due to environmental-dependent epigenetic information alteration, including DNA methylation, histone modifications, and noncoding RNAs. Changes in this epigenetic information potentially damage our health, which has also been supported by numerous epidemiological and animal studies in recent years. Environmental factors functionally affect embryo development through epimutation, transmitting diseases to offspring and even later generations. This review mainly elaborated on the concept of developmental origins of adult diseases, and revealed the epigenetic mechanisms underlying these events, discussed the theoretical basis for the prevention and treatment of related diseases. |
| first_indexed | 2024-04-09T18:32:25Z |
| format | Article |
| id | doaj.art-e3322979d1c64c8fbe8e87c461a5f861 |
| institution | Directory Open Access Journal |
| issn | 2749-9642 |
| language | English |
| last_indexed | 2024-04-09T18:32:25Z |
| publishDate | 2022-10-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Medical Review |
| spelling | doaj.art-e3322979d1c64c8fbe8e87c461a5f8612023-04-11T17:07:17ZengDe GruyterMedical Review2749-96422022-10-012545047010.1515/mr-2022-0027Developmental origins of adult diseasesMo Jiaying0Liu Xuanqi1Huang Yutong2He Renke3Zhang Yu4Huang Hefeng5Department of Obstetrics and Gynecology, The Fourth Affiliated Hospital, International Institutes of Medicine, Zhejiang University School of Medicine, Yiwu, Zhejiang Province, ChinaThe Key Laboratory of Reproductive Genetics (Zhejiang University), Ministry of Education, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, ChinaThe Key Laboratory of Reproductive Genetics (Zhejiang University), Ministry of Education, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, ChinaDepartment of Obstetrics and Gynecology, The Fourth Affiliated Hospital, International Institutes of Medicine, Zhejiang University School of Medicine, Yiwu, Zhejiang Province, ChinaObstetrics and Gynecology Hospital, Institute of Reproduction and Development, Fudan University, Shanghai, ChinaDepartment of Obstetrics and Gynecology, The Fourth Affiliated Hospital, International Institutes of Medicine, Zhejiang University School of Medicine, Yiwu, Zhejiang Province, ChinaThe occurrence and mechanisms of developmental adult diseases have gradually attracted attention in recent years. Exposure of gametes and embryos to adverse environments, especially during plastic development, can alter the expression of certain tissue-specific genes, leading to increased susceptibility to certain diseases in adulthood, such as diabetes, cardiovascular disease, neuropsychiatric, and reproductive system diseases, etc. The occurrence of chronic disease in adulthood is partly due to genetic factors, and the remaining risk is partly due to environmental-dependent epigenetic information alteration, including DNA methylation, histone modifications, and noncoding RNAs. Changes in this epigenetic information potentially damage our health, which has also been supported by numerous epidemiological and animal studies in recent years. Environmental factors functionally affect embryo development through epimutation, transmitting diseases to offspring and even later generations. This review mainly elaborated on the concept of developmental origins of adult diseases, and revealed the epigenetic mechanisms underlying these events, discussed the theoretical basis for the prevention and treatment of related diseases.https://doi.org/10.1515/mr-2022-0027embryos developmentepigeneticgametesnon-communicable diseases |
| spellingShingle | Mo Jiaying Liu Xuanqi Huang Yutong He Renke Zhang Yu Huang Hefeng Developmental origins of adult diseases Medical Review embryos development epigenetic gametes non-communicable diseases |
| title | Developmental origins of adult diseases |
| title_full | Developmental origins of adult diseases |
| title_fullStr | Developmental origins of adult diseases |
| title_full_unstemmed | Developmental origins of adult diseases |
| title_short | Developmental origins of adult diseases |
| title_sort | developmental origins of adult diseases |
| topic | embryos development epigenetic gametes non-communicable diseases |
| url | https://doi.org/10.1515/mr-2022-0027 |
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