Generation of four human induced pluripotent stem cell lines from COVID-19 hospitalized patients with increased levels of cardiac Troponin in the acute infection phase developing or not myocarditis
Coronavirus disease (COVID-19) is an infectious disease caused by SARS-CoV-2 virus, leading to mild to severe respiratory symptoms. Cardiovascular involvement is frequent and mainly manifests with myocarditis, arrhythmias, cardiac arrests, heart failure and coagulation abnormality. We generated huma...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-03-01
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| Series: | Stem Cell Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1873506123000041 |
| _version_ | 1797897332591689728 |
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| author | Martina Rabino Erica Rurali Chiara Zamboni Davide Rovina Sara Mallia Matteo Cauteruccio Andrea Baggiano Carlo Maria Giacari Milena Bellin Giulio Pompilio |
| author_facet | Martina Rabino Erica Rurali Chiara Zamboni Davide Rovina Sara Mallia Matteo Cauteruccio Andrea Baggiano Carlo Maria Giacari Milena Bellin Giulio Pompilio |
| author_sort | Martina Rabino |
| collection | DOAJ |
| description | Coronavirus disease (COVID-19) is an infectious disease caused by SARS-CoV-2 virus, leading to mild to severe respiratory symptoms. Cardiovascular involvement is frequent and mainly manifests with myocarditis, arrhythmias, cardiac arrests, heart failure and coagulation abnormality. We generated human induced pluripotent stem cells (hiPSCs) from four COVID-19 patients, all characterized by increased levels of high-sensitivity Troponin I (hsTnI) during the infection acute phase, who developed (n = 2) or not (n = 2) severe myocarditis, as COVID-19 complication. The established hiPSCs were characterized for pluripotency and genomic stability, and constitute a useful resource for studying the mechanisms underlying the variability in COVID-19 severe cardiac manifestations. |
| first_indexed | 2024-04-10T07:55:51Z |
| format | Article |
| id | doaj.art-e333f93aa82d4a948b10776b34e1ee80 |
| institution | Directory Open Access Journal |
| issn | 1873-5061 |
| language | English |
| last_indexed | 2024-04-10T07:55:51Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Stem Cell Research |
| spelling | doaj.art-e333f93aa82d4a948b10776b34e1ee802023-02-23T04:30:51ZengElsevierStem Cell Research1873-50612023-03-0167103018Generation of four human induced pluripotent stem cell lines from COVID-19 hospitalized patients with increased levels of cardiac Troponin in the acute infection phase developing or not myocarditisMartina Rabino0Erica Rurali1Chiara Zamboni2Davide Rovina3Sara Mallia4Matteo Cauteruccio5Andrea Baggiano6Carlo Maria Giacari7Milena Bellin8Giulio Pompilio9Unit of Vascular Biology and Regenerative Medicine, Centro Cardiologico Monzino IRCCS, Milan, Italy; Corresponding author at: Unit of Vascular Biology and Regenerative Medicine, Centro Cardiologico Monzino IRCCS, Milan, Italy.Unit of Vascular Biology and Regenerative Medicine, Centro Cardiologico Monzino IRCCS, Milan, ItalyUnit of Vascular Biology and Regenerative Medicine, Centro Cardiologico Monzino IRCCS, Milan, ItalyUnit of Vascular Biology and Regenerative Medicine, Centro Cardiologico Monzino IRCCS, Milan, ItalyUnit of Vascular Biology and Regenerative Medicine, Centro Cardiologico Monzino IRCCS, Milan, ItalyUnit of Vascular Biology and Regenerative Medicine, Centro Cardiologico Monzino IRCCS, Milan, ItalyPeri Operative Cardiology and Cardiovascular Imaging Department, Centro Cardiologico Monzino IRCCS, Milan, Italy; Dipartimento di Scienze Cliniche e di Comunità, Università degli Studi di Milano, Milan, ItalyPeri Operative Cardiology and Cardiovascular Imaging Department, Centro Cardiologico Monzino IRCCS, Milan, ItalyDepartment of Biology, University of Padova, Padova, Italy; Veneto Institute of Molecular Medicine, Padova, Italy; Departmant of Anatomy and Embryology, Leiden University Medical Center, Leiden, the NetherlandsUnit of Vascular Biology and Regenerative Medicine, Centro Cardiologico Monzino IRCCS, Milan, Italy; Dipartimento di Scienze Biomediche, Chirurgiche ed Odontoiatriche, Università degli Studi di Milano, Milan, ItalyCoronavirus disease (COVID-19) is an infectious disease caused by SARS-CoV-2 virus, leading to mild to severe respiratory symptoms. Cardiovascular involvement is frequent and mainly manifests with myocarditis, arrhythmias, cardiac arrests, heart failure and coagulation abnormality. We generated human induced pluripotent stem cells (hiPSCs) from four COVID-19 patients, all characterized by increased levels of high-sensitivity Troponin I (hsTnI) during the infection acute phase, who developed (n = 2) or not (n = 2) severe myocarditis, as COVID-19 complication. The established hiPSCs were characterized for pluripotency and genomic stability, and constitute a useful resource for studying the mechanisms underlying the variability in COVID-19 severe cardiac manifestations.http://www.sciencedirect.com/science/article/pii/S1873506123000041 |
| spellingShingle | Martina Rabino Erica Rurali Chiara Zamboni Davide Rovina Sara Mallia Matteo Cauteruccio Andrea Baggiano Carlo Maria Giacari Milena Bellin Giulio Pompilio Generation of four human induced pluripotent stem cell lines from COVID-19 hospitalized patients with increased levels of cardiac Troponin in the acute infection phase developing or not myocarditis Stem Cell Research |
| title | Generation of four human induced pluripotent stem cell lines from COVID-19 hospitalized patients with increased levels of cardiac Troponin in the acute infection phase developing or not myocarditis |
| title_full | Generation of four human induced pluripotent stem cell lines from COVID-19 hospitalized patients with increased levels of cardiac Troponin in the acute infection phase developing or not myocarditis |
| title_fullStr | Generation of four human induced pluripotent stem cell lines from COVID-19 hospitalized patients with increased levels of cardiac Troponin in the acute infection phase developing or not myocarditis |
| title_full_unstemmed | Generation of four human induced pluripotent stem cell lines from COVID-19 hospitalized patients with increased levels of cardiac Troponin in the acute infection phase developing or not myocarditis |
| title_short | Generation of four human induced pluripotent stem cell lines from COVID-19 hospitalized patients with increased levels of cardiac Troponin in the acute infection phase developing or not myocarditis |
| title_sort | generation of four human induced pluripotent stem cell lines from covid 19 hospitalized patients with increased levels of cardiac troponin in the acute infection phase developing or not myocarditis |
| url | http://www.sciencedirect.com/science/article/pii/S1873506123000041 |
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