Catalytic deAMPylation in AMPylation-inhibitory/assistant forms of FICD protein

Catalytic deAMPylation in AMPylation-inhibitory/assistant forms of FICD protein

DeAMPylation, as a reversible reaction of AMPylation and mediated by the endoplasmic reticulum-localized enzyme FICD (filamentation induced by cAMP domain protein, also known as HYPE), is an important process in protein posttranslational modifications (PTMs). Elucidating the function and catalytic d...

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Bibliographic Details
Main Authors: Meili Liu, Li Li, Zhiqin Wang, Shuang Wang, Xiaowen Tang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Chemistry
Subjects:
FICD protein
deAMPylation
inhibitory helix
QM/MM MD
catalytic mechanism
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2023.1077188/full

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