Protective Role of Polyphenols in Heart Failure: Molecular Targets and Cellular Mechanisms Underlying Their Therapeutic Potential
Heart failure (HF) is a leading cause of death in the United States, with a 5-year mortality rate of 50% despite modern pharmacological therapies. Plant-based diets are comprised of a diverse polyphenol profile, which lends to their association with reduced cardiovascular disease risk. Whether a pol...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/4/1668 |
| _version_ | 1797413354257514496 |
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| author | Rami S. Najjar Rafaela G. Feresin |
| author_facet | Rami S. Najjar Rafaela G. Feresin |
| author_sort | Rami S. Najjar |
| collection | DOAJ |
| description | Heart failure (HF) is a leading cause of death in the United States, with a 5-year mortality rate of 50% despite modern pharmacological therapies. Plant-based diets are comprised of a diverse polyphenol profile, which lends to their association with reduced cardiovascular disease risk. Whether a polyphenol-rich diet can slow the progression of or reverse HF in humans is not known. To date, in vitro and in vivo studies have reported on the protective role of polyphenols in HF. In this review, we will discuss the major mechanisms by which polyphenols mitigate HF in vitro and in vivo, including (1) reduced cardiac inflammation and oxidative stress, (2) reduced mitochondrial dysfunction, (3) improved Ca<sup>2+</sup> homeostasis, (4) increased survival signaling, and (5) increased sirtuin 1 activity. |
| first_indexed | 2024-03-09T05:16:28Z |
| format | Article |
| id | doaj.art-e33633ba91b74b1e94ee798212b86493 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T05:16:28Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e33633ba91b74b1e94ee798212b864932023-12-03T12:45:38ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-02-01224166810.3390/ijms22041668Protective Role of Polyphenols in Heart Failure: Molecular Targets and Cellular Mechanisms Underlying Their Therapeutic PotentialRami S. Najjar0Rafaela G. Feresin1Department of Nutrition, Georgia State University, Atlanta, GA 30302, USADepartment of Nutrition, Georgia State University, Atlanta, GA 30302, USAHeart failure (HF) is a leading cause of death in the United States, with a 5-year mortality rate of 50% despite modern pharmacological therapies. Plant-based diets are comprised of a diverse polyphenol profile, which lends to their association with reduced cardiovascular disease risk. Whether a polyphenol-rich diet can slow the progression of or reverse HF in humans is not known. To date, in vitro and in vivo studies have reported on the protective role of polyphenols in HF. In this review, we will discuss the major mechanisms by which polyphenols mitigate HF in vitro and in vivo, including (1) reduced cardiac inflammation and oxidative stress, (2) reduced mitochondrial dysfunction, (3) improved Ca<sup>2+</sup> homeostasis, (4) increased survival signaling, and (5) increased sirtuin 1 activity.https://www.mdpi.com/1422-0067/22/4/1668polyphenolsflavonoidsplant-based dietsheart failureinflammationoxidative stress |
| spellingShingle | Rami S. Najjar Rafaela G. Feresin Protective Role of Polyphenols in Heart Failure: Molecular Targets and Cellular Mechanisms Underlying Their Therapeutic Potential International Journal of Molecular Sciences polyphenols flavonoids plant-based diets heart failure inflammation oxidative stress |
| title | Protective Role of Polyphenols in Heart Failure: Molecular Targets and Cellular Mechanisms Underlying Their Therapeutic Potential |
| title_full | Protective Role of Polyphenols in Heart Failure: Molecular Targets and Cellular Mechanisms Underlying Their Therapeutic Potential |
| title_fullStr | Protective Role of Polyphenols in Heart Failure: Molecular Targets and Cellular Mechanisms Underlying Their Therapeutic Potential |
| title_full_unstemmed | Protective Role of Polyphenols in Heart Failure: Molecular Targets and Cellular Mechanisms Underlying Their Therapeutic Potential |
| title_short | Protective Role of Polyphenols in Heart Failure: Molecular Targets and Cellular Mechanisms Underlying Their Therapeutic Potential |
| title_sort | protective role of polyphenols in heart failure molecular targets and cellular mechanisms underlying their therapeutic potential |
| topic | polyphenols flavonoids plant-based diets heart failure inflammation oxidative stress |
| url | https://www.mdpi.com/1422-0067/22/4/1668 |
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