Crosstalk between Statins and Cancer Prevention and Therapy: An Update
The importance of statins in cancer has been discussed in many studies. They are known for their anticancer properties against solid tumors of the liver or lung, as well as diffuse cancers, such as multiple myeloma or leukemia. Currently, the most commonly used statins are simvastatin, rosuvastatin...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/14/12/1220 |
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| author | Beniamin Oskar Grabarek Dariusz Boroń Emilia Morawiec Piotr Michalski Veronica Palazzo-Michalska Łukasz Pach Barbara Dziuk Magdalena Świder Nikola Zmarzły |
| author_facet | Beniamin Oskar Grabarek Dariusz Boroń Emilia Morawiec Piotr Michalski Veronica Palazzo-Michalska Łukasz Pach Barbara Dziuk Magdalena Świder Nikola Zmarzły |
| author_sort | Beniamin Oskar Grabarek |
| collection | DOAJ |
| description | The importance of statins in cancer has been discussed in many studies. They are known for their anticancer properties against solid tumors of the liver or lung, as well as diffuse cancers, such as multiple myeloma or leukemia. Currently, the most commonly used statins are simvastatin, rosuvastatin and atorvastatin. The anti-tumor activity of statins is largely related to their ability to induce apoptosis by targeting cancer cells with high selectivity. Statins are also involved in the regulation of the histone acetylation level, the disturbance of which can lead to abnormal activity of genes involved in the regulation of proliferation, differentiation and apoptosis. As a result, tumor growth and its invasion may be promoted, which is associated with a poor prognosis. High levels of histone deacetylases are observed in many cancers; therefore, one of the therapeutic strategies is to use their inhibitors. Combining statins with histone deacetylase inhibitors can induce a synergistic anticancer effect. |
| first_indexed | 2024-03-10T03:21:56Z |
| format | Article |
| id | doaj.art-e336d91bc3054b64b99a7de93d02ec9d |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-10T03:21:56Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-e336d91bc3054b64b99a7de93d02ec9d2023-11-23T10:02:38ZengMDPI AGPharmaceuticals1424-82472021-11-011412122010.3390/ph14121220Crosstalk between Statins and Cancer Prevention and Therapy: An UpdateBeniamin Oskar Grabarek0Dariusz Boroń1Emilia Morawiec2Piotr Michalski3Veronica Palazzo-Michalska4Łukasz Pach5Barbara Dziuk6Magdalena Świder7Nikola Zmarzły8Department of Histology, Cytophysiology and Embryology, Faculty of Medicine, University of Technology in Katowice, 41-800 Zabrze, PolandDepartment of Histology, Cytophysiology and Embryology, Faculty of Medicine, University of Technology in Katowice, 41-800 Zabrze, PolandDepartment of Histology, Cytophysiology and Embryology, Faculty of Medicine, University of Technology in Katowice, 41-800 Zabrze, PolandDepartment of Pathophysiology, Faculty of Medicine, University of Technology in Katowice, 41-800 Zabrze, PolandDepartment of Pathophysiology, Faculty of Medicine, University of Technology in Katowice, 41-800 Zabrze, PolandVoivodeship Emergency in Katowice, 40-055 Katowice, PolandDepartment of Histology, Cytophysiology and Embryology, Faculty of Medicine, University of Technology in Katowice, 41-800 Zabrze, PolandDepartment of Histology, Cytophysiology and Embryology, Faculty of Medicine, University of Technology in Katowice, 41-800 Zabrze, PolandDepartment of Histology, Cytophysiology and Embryology, Faculty of Medicine, University of Technology in Katowice, 41-800 Zabrze, PolandThe importance of statins in cancer has been discussed in many studies. They are known for their anticancer properties against solid tumors of the liver or lung, as well as diffuse cancers, such as multiple myeloma or leukemia. Currently, the most commonly used statins are simvastatin, rosuvastatin and atorvastatin. The anti-tumor activity of statins is largely related to their ability to induce apoptosis by targeting cancer cells with high selectivity. Statins are also involved in the regulation of the histone acetylation level, the disturbance of which can lead to abnormal activity of genes involved in the regulation of proliferation, differentiation and apoptosis. As a result, tumor growth and its invasion may be promoted, which is associated with a poor prognosis. High levels of histone deacetylases are observed in many cancers; therefore, one of the therapeutic strategies is to use their inhibitors. Combining statins with histone deacetylase inhibitors can induce a synergistic anticancer effect.https://www.mdpi.com/1424-8247/14/12/1220statinscancercancer preventionanticancer therapy |
| spellingShingle | Beniamin Oskar Grabarek Dariusz Boroń Emilia Morawiec Piotr Michalski Veronica Palazzo-Michalska Łukasz Pach Barbara Dziuk Magdalena Świder Nikola Zmarzły Crosstalk between Statins and Cancer Prevention and Therapy: An Update Pharmaceuticals statins cancer cancer prevention anticancer therapy |
| title | Crosstalk between Statins and Cancer Prevention and Therapy: An Update |
| title_full | Crosstalk between Statins and Cancer Prevention and Therapy: An Update |
| title_fullStr | Crosstalk between Statins and Cancer Prevention and Therapy: An Update |
| title_full_unstemmed | Crosstalk between Statins and Cancer Prevention and Therapy: An Update |
| title_short | Crosstalk between Statins and Cancer Prevention and Therapy: An Update |
| title_sort | crosstalk between statins and cancer prevention and therapy an update |
| topic | statins cancer cancer prevention anticancer therapy |
| url | https://www.mdpi.com/1424-8247/14/12/1220 |
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