The Telomeric Protein TRF2 Regulates Replication Origin Activity within Pericentromeric Heterochromatin

The Telomeric Protein TRF2 Regulates Replication Origin Activity within Pericentromeric Heterochromatin

Heterochromatic regions render the replication process particularly difficult due to the high level of chromatin compaction and the presence of repeated DNA sequences. In humans, replication through pericentromeric heterochromatin requires the binding of a complex formed by the telomeric factor TRF2...

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Bibliographic Details
Main Authors: Serge Bauwens, Liudmyla Lototska, Stephane Koundrioukoff, Michelle Debatisse, Jing Ye, Eric Gilson, Aaron Mendez-Bermudez
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Life
Subjects:
TRF2
heterochromatin
pericentromeric DNA
ORC
replication
telomeres
Online Access:https://www.mdpi.com/2075-1729/11/4/267

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