Structural insights into the substrate-bound condensation domains of non-ribosomal peptide synthetase AmbB

Structural insights into the substrate-bound condensation domains of non-ribosomal peptide synthetase AmbB

Abstract Non-ribosomal peptide synthetases (NRPS) are multi-modular/domain enzymes that catalyze the synthesis of bioactive peptides. A crucial step in the process is peptide elongation accomplished by the condensation (C) domain with the aid of a peptidyl carrier or thiolation (T) domain. Here, we...

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Bibliographic Details
Main Authors: Melissa-Jane Chu Yuan Kee, Sakshibeedu R. Bharath, Sheena Wee, Matthew W. Bowler, Jayantha Gunaratne, Shenquan Pan, Lianhui Zhang, Haiwei Song
Format: Article
Language:English
Published: Nature Portfolio 2022-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-09188-8

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