Identification of correlation between human papillomavirus and prostate cancer: Bradford Hill Criteria Based Evaluation.
Background: Human papillomavirus (HPV) association has effectively been decoded in prostate cancer (PC) worldwide with controverting conclusions. Though the different groups of researchers explored the potential association of HPV with PC using meta-analysis but it still remains controversial due t...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Advance Educational Institute & Research Centre
2021-06-01
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| Series: | International Journal of Endorsing Health Science Research |
| Subjects: | |
| Online Access: | http://aeirc-edu.com/ojs14/index.php/IJEHSR/article/view/623 |
| _version_ | 1818319789195526144 |
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| author | Muhammad Usman Mukhtiar Ahmad Yasir Hameed Hamad Ahmed Muhammad Safdar Hussain Jalil Ur Rehman Rizwan Arshad Muhammad Atif |
| author_facet | Muhammad Usman Mukhtiar Ahmad Yasir Hameed Hamad Ahmed Muhammad Safdar Hussain Jalil Ur Rehman Rizwan Arshad Muhammad Atif |
| author_sort | Muhammad Usman |
| collection | DOAJ |
| description |
Background: Human papillomavirus (HPV) association has effectively been decoded in prostate cancer (PC) worldwide with controverting conclusions. Though the different groups of researchers explored the potential association of HPV with PC using meta-analysis but it still remains controversial due to the major limitations. Therefore, the present study was designed to investigate the potential link of HPV with PC using Bradford Hill criteria.
Methodology: Initially using PubMed, we extracted studies that associated HPV to PC. Then, to assess the potential association of HPV with PC, an examination of the available data on HPV in PC, normal/benign samples was conducted using all the major Bradford Hill criteria postulates. Furthermore, to improve the authenticity of the present study, we have also critically evaluated the methodologies of the identified studies to check the possibility of false-negative and false-positive results.
Results: After a careful assessment of the previous studies against Bradford Hill criteria postulates, we observed that all the major postulates were not fulfilled, including strength, temporality, consistency, plausibility, biological gradient, experiment, specificity, and analogy.
Conclusion: The findings of this systematic review suggest no casual association of HPV with PC.
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| first_indexed | 2024-12-13T10:14:41Z |
| format | Article |
| id | doaj.art-e33a9869b59242c687d0e8fbad87f0c8 |
| institution | Directory Open Access Journal |
| issn | 2307-3748 2310-3841 |
| language | English |
| last_indexed | 2024-12-13T10:14:41Z |
| publishDate | 2021-06-01 |
| publisher | Advance Educational Institute & Research Centre |
| record_format | Article |
| series | International Journal of Endorsing Health Science Research |
| spelling | doaj.art-e33a9869b59242c687d0e8fbad87f0c82022-12-21T23:51:21ZengAdvance Educational Institute & Research CentreInternational Journal of Endorsing Health Science Research2307-37482310-38412021-06-019210.29052/IJEHSR.v9.i2.2021.248-256Identification of correlation between human papillomavirus and prostate cancer: Bradford Hill Criteria Based Evaluation.Muhammad Usman0Mukhtiar Ahmad1Yasir Hameed2Hamad Ahmed3Muhammad Safdar Hussain4Jalil Ur Rehman5Rizwan Arshad6Muhammad Atif7Department of Biochemistry and Biotechnology, The Islamia University of Bahawalpur, Bahawalpur-Pakistan.Department of Biochemistry and Biotechnology, The Islamia University of Bahawalpur, Bahawalpur-Pakistan.Department of Biochemistry and Biotechnology, The Islamia University of Bahawalpur, Bahawalpur-Pakistan.Department of Eastern Medicine, Government College University, Faisalabad-Pakistan.Department of Eastern Medicine, Government College University, Faisalabad-Pakistan.University College of conventional Medicine, Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Bahawalpur-Pakistan.University College of conventional Medicine, Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Bahawalpur-Pakistan.University College of conventional Medicine, Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Bahawalpur-Pakistan. Background: Human papillomavirus (HPV) association has effectively been decoded in prostate cancer (PC) worldwide with controverting conclusions. Though the different groups of researchers explored the potential association of HPV with PC using meta-analysis but it still remains controversial due to the major limitations. Therefore, the present study was designed to investigate the potential link of HPV with PC using Bradford Hill criteria. Methodology: Initially using PubMed, we extracted studies that associated HPV to PC. Then, to assess the potential association of HPV with PC, an examination of the available data on HPV in PC, normal/benign samples was conducted using all the major Bradford Hill criteria postulates. Furthermore, to improve the authenticity of the present study, we have also critically evaluated the methodologies of the identified studies to check the possibility of false-negative and false-positive results. Results: After a careful assessment of the previous studies against Bradford Hill criteria postulates, we observed that all the major postulates were not fulfilled, including strength, temporality, consistency, plausibility, biological gradient, experiment, specificity, and analogy. Conclusion: The findings of this systematic review suggest no casual association of HPV with PC. http://aeirc-edu.com/ojs14/index.php/IJEHSR/article/view/623Prostate Cancer, Bradford Hill Criteria, Statistical Meta-Analysis, Human Papillomavirus. |
| spellingShingle | Muhammad Usman Mukhtiar Ahmad Yasir Hameed Hamad Ahmed Muhammad Safdar Hussain Jalil Ur Rehman Rizwan Arshad Muhammad Atif Identification of correlation between human papillomavirus and prostate cancer: Bradford Hill Criteria Based Evaluation. International Journal of Endorsing Health Science Research Prostate Cancer, Bradford Hill Criteria, Statistical Meta-Analysis, Human Papillomavirus. |
| title | Identification of correlation between human papillomavirus and prostate cancer: Bradford Hill Criteria Based Evaluation. |
| title_full | Identification of correlation between human papillomavirus and prostate cancer: Bradford Hill Criteria Based Evaluation. |
| title_fullStr | Identification of correlation between human papillomavirus and prostate cancer: Bradford Hill Criteria Based Evaluation. |
| title_full_unstemmed | Identification of correlation between human papillomavirus and prostate cancer: Bradford Hill Criteria Based Evaluation. |
| title_short | Identification of correlation between human papillomavirus and prostate cancer: Bradford Hill Criteria Based Evaluation. |
| title_sort | identification of correlation between human papillomavirus and prostate cancer bradford hill criteria based evaluation |
| topic | Prostate Cancer, Bradford Hill Criteria, Statistical Meta-Analysis, Human Papillomavirus. |
| url | http://aeirc-edu.com/ojs14/index.php/IJEHSR/article/view/623 |
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