Regression of corneal opacity and neovascularization in Stevens-Johnson syndrome and Toxic Epidermal Necrolysis with the use of prosthetic replacement of the ocular surface ecosystem (PROSE) treatment
Purpose: To report two cases demonstrating the regression of corneal neovascularization and clearing of corneal opacification in patients with Stevens Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) undergoing prosthetic replacement of the ocular surface ecosystem (PROSE) treatment. Obse...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | American Journal of Ophthalmology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451993622002663 |
| _version_ | 1818211821116456960 |
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| author | Jennifer Liao, OD Bita Asghari, OD Karen G. Carrasquillo, OD, PhD |
| author_facet | Jennifer Liao, OD Bita Asghari, OD Karen G. Carrasquillo, OD, PhD |
| author_sort | Jennifer Liao, OD |
| collection | DOAJ |
| description | Purpose: To report two cases demonstrating the regression of corneal neovascularization and clearing of corneal opacification in patients with Stevens Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) undergoing prosthetic replacement of the ocular surface ecosystem (PROSE) treatment. Observations: Four eyes of 2 patients were analyzed. Regression of neovascularization and clearing of corneal opacification was observed in both patients. All 4 eyes demonstrated improvement in visual acuity with treatment. With treatment, both patients ultimately discontinued all prescribed topical therapies. It was discovered upon review of these cases that all 4 eyes were managed with PROSE devices designed with back-surface channeled haptics. Conclusions and Importance: There currently is no known literature reporting on long-term regression of corneal neovascularization or clearing of corneal opacity in SJS or TEN patients with the use of scleral prosthetic devices. This report of 2 cases highlights the improvement in corneal function with PROSE treatment involving the use of channeled designs in patients with SJS or TEN. More research is needed to better understand how PROSE or scleral lens design features affect patient outcomes and why some patients may show regression in corneal neovascularization. |
| first_indexed | 2024-12-12T05:38:35Z |
| format | Article |
| id | doaj.art-e33ac55671804a1580299f87eeacbbe4 |
| institution | Directory Open Access Journal |
| issn | 2451-9936 |
| language | English |
| last_indexed | 2024-12-12T05:38:35Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Journal of Ophthalmology Case Reports |
| spelling | doaj.art-e33ac55671804a1580299f87eeacbbe42022-12-22T00:36:01ZengElsevierAmerican Journal of Ophthalmology Case Reports2451-99362022-06-0126101520Regression of corneal opacity and neovascularization in Stevens-Johnson syndrome and Toxic Epidermal Necrolysis with the use of prosthetic replacement of the ocular surface ecosystem (PROSE) treatmentJennifer Liao, OD0Bita Asghari, OD1Karen G. Carrasquillo, OD, PhD2New England College of Optometry, 424 Beacon St, Boston, MA, 02115, USABostonSight, 464 Hillside Ave., Suite 205, Needham, MA, 02494, USABostonSight, 464 Hillside Ave., Suite 205, Needham, MA, 02494, USA; Corresponding author.Purpose: To report two cases demonstrating the regression of corneal neovascularization and clearing of corneal opacification in patients with Stevens Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) undergoing prosthetic replacement of the ocular surface ecosystem (PROSE) treatment. Observations: Four eyes of 2 patients were analyzed. Regression of neovascularization and clearing of corneal opacification was observed in both patients. All 4 eyes demonstrated improvement in visual acuity with treatment. With treatment, both patients ultimately discontinued all prescribed topical therapies. It was discovered upon review of these cases that all 4 eyes were managed with PROSE devices designed with back-surface channeled haptics. Conclusions and Importance: There currently is no known literature reporting on long-term regression of corneal neovascularization or clearing of corneal opacity in SJS or TEN patients with the use of scleral prosthetic devices. This report of 2 cases highlights the improvement in corneal function with PROSE treatment involving the use of channeled designs in patients with SJS or TEN. More research is needed to better understand how PROSE or scleral lens design features affect patient outcomes and why some patients may show regression in corneal neovascularization.http://www.sciencedirect.com/science/article/pii/S2451993622002663Stevens-Johnson syndromeToxic epidermal necrolysisPROSE treatmentCorneal opacityCorneal neovascularizationScleral lenses |
| spellingShingle | Jennifer Liao, OD Bita Asghari, OD Karen G. Carrasquillo, OD, PhD Regression of corneal opacity and neovascularization in Stevens-Johnson syndrome and Toxic Epidermal Necrolysis with the use of prosthetic replacement of the ocular surface ecosystem (PROSE) treatment American Journal of Ophthalmology Case Reports Stevens-Johnson syndrome Toxic epidermal necrolysis PROSE treatment Corneal opacity Corneal neovascularization Scleral lenses |
| title | Regression of corneal opacity and neovascularization in Stevens-Johnson syndrome and Toxic Epidermal Necrolysis with the use of prosthetic replacement of the ocular surface ecosystem (PROSE) treatment |
| title_full | Regression of corneal opacity and neovascularization in Stevens-Johnson syndrome and Toxic Epidermal Necrolysis with the use of prosthetic replacement of the ocular surface ecosystem (PROSE) treatment |
| title_fullStr | Regression of corneal opacity and neovascularization in Stevens-Johnson syndrome and Toxic Epidermal Necrolysis with the use of prosthetic replacement of the ocular surface ecosystem (PROSE) treatment |
| title_full_unstemmed | Regression of corneal opacity and neovascularization in Stevens-Johnson syndrome and Toxic Epidermal Necrolysis with the use of prosthetic replacement of the ocular surface ecosystem (PROSE) treatment |
| title_short | Regression of corneal opacity and neovascularization in Stevens-Johnson syndrome and Toxic Epidermal Necrolysis with the use of prosthetic replacement of the ocular surface ecosystem (PROSE) treatment |
| title_sort | regression of corneal opacity and neovascularization in stevens johnson syndrome and toxic epidermal necrolysis with the use of prosthetic replacement of the ocular surface ecosystem prose treatment |
| topic | Stevens-Johnson syndrome Toxic epidermal necrolysis PROSE treatment Corneal opacity Corneal neovascularization Scleral lenses |
| url | http://www.sciencedirect.com/science/article/pii/S2451993622002663 |
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