Gut Microbiota and Iron: The Crucial Actors in Health and Disease
Iron (Fe) is a highly ample metal on planet earth (~35% of the Earth’s mass) and is particularly essential for most life forms, including from bacteria to mammals. Nonetheless, iron deficiency is highly prevalent in developing countries, and oral administration of this metal is so far the...
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| Format: | Article |
| Language: | English |
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MDPI AG
2018-10-01
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| Series: | Pharmaceuticals |
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| Online Access: | http://www.mdpi.com/1424-8247/11/4/98 |
| _version_ | 1818884693112651776 |
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| author | Bahtiyar Yilmaz Hai Li |
| author_facet | Bahtiyar Yilmaz Hai Li |
| author_sort | Bahtiyar Yilmaz |
| collection | DOAJ |
| description | Iron (Fe) is a highly ample metal on planet earth (~35% of the Earth’s mass) and is particularly essential for most life forms, including from bacteria to mammals. Nonetheless, iron deficiency is highly prevalent in developing countries, and oral administration of this metal is so far the most effective treatment for human beings. Notably, the excessive amount of unabsorbed iron leave unappreciated side effects at the highly interactive host–microbe interface of the human gastrointestinal tract. Recent advances in elucidating the molecular basis of interactions between iron and gut microbiota shed new light(s) on the health and pathogenesis of intestinal inflammatory diseases. We here aim to present the dynamic modulation of intestinal microbiota by iron availability, and conversely, the influence on dietary iron absorption in the gut. The central part of this review is intended to summarize our current understanding about the effects of luminal iron on host–microbe interactions in the context of human health and disease. |
| first_indexed | 2024-12-19T15:53:36Z |
| format | Article |
| id | doaj.art-e33aee1eb9ef4de5a63794b064903775 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-12-19T15:53:36Z |
| publishDate | 2018-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-e33aee1eb9ef4de5a63794b0649037752022-12-21T20:15:09ZengMDPI AGPharmaceuticals1424-82472018-10-011149810.3390/ph11040098ph11040098Gut Microbiota and Iron: The Crucial Actors in Health and DiseaseBahtiyar Yilmaz0Hai Li1Maurice Müller Laboratories, Department of Biomedical Research, University of Bern, 3008 Bern, SwitzerlandMaurice Müller Laboratories, Department of Biomedical Research, University of Bern, 3008 Bern, SwitzerlandIron (Fe) is a highly ample metal on planet earth (~35% of the Earth’s mass) and is particularly essential for most life forms, including from bacteria to mammals. Nonetheless, iron deficiency is highly prevalent in developing countries, and oral administration of this metal is so far the most effective treatment for human beings. Notably, the excessive amount of unabsorbed iron leave unappreciated side effects at the highly interactive host–microbe interface of the human gastrointestinal tract. Recent advances in elucidating the molecular basis of interactions between iron and gut microbiota shed new light(s) on the health and pathogenesis of intestinal inflammatory diseases. We here aim to present the dynamic modulation of intestinal microbiota by iron availability, and conversely, the influence on dietary iron absorption in the gut. The central part of this review is intended to summarize our current understanding about the effects of luminal iron on host–microbe interactions in the context of human health and disease.http://www.mdpi.com/1424-8247/11/4/98irongut microbiotairon supplementationiron transportersmucosal immunitySCFAintestinal inflammationinflammatory bowel disease (IBD)colorectal cancer |
| spellingShingle | Bahtiyar Yilmaz Hai Li Gut Microbiota and Iron: The Crucial Actors in Health and Disease Pharmaceuticals iron gut microbiota iron supplementation iron transporters mucosal immunity SCFA intestinal inflammation inflammatory bowel disease (IBD) colorectal cancer |
| title | Gut Microbiota and Iron: The Crucial Actors in Health and Disease |
| title_full | Gut Microbiota and Iron: The Crucial Actors in Health and Disease |
| title_fullStr | Gut Microbiota and Iron: The Crucial Actors in Health and Disease |
| title_full_unstemmed | Gut Microbiota and Iron: The Crucial Actors in Health and Disease |
| title_short | Gut Microbiota and Iron: The Crucial Actors in Health and Disease |
| title_sort | gut microbiota and iron the crucial actors in health and disease |
| topic | iron gut microbiota iron supplementation iron transporters mucosal immunity SCFA intestinal inflammation inflammatory bowel disease (IBD) colorectal cancer |
| url | http://www.mdpi.com/1424-8247/11/4/98 |
| work_keys_str_mv | AT bahtiyaryilmaz gutmicrobiotaandironthecrucialactorsinhealthanddisease AT haili gutmicrobiotaandironthecrucialactorsinhealthanddisease |