Diabetes mellitus: renal osmoregulating function
Aim. To evaluate the kidney status from osmotic urine concentration in different stages of diabetes mellitus (DM) to define whether not only glomeruli and proximal tubules, but also renal medullary substance structures are involved into the pathological process, as well as their reaction to endogeno...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2010-06-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/30575 |
| _version_ | 1811210273291239424 |
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| author | Yu V Natochin M V Shestakova A A Kuznetsova I I Klefortova N P Trubitsyna I I Dedov |
| author_facet | Yu V Natochin M V Shestakova A A Kuznetsova I I Klefortova N P Trubitsyna I I Dedov |
| author_sort | Yu V Natochin |
| collection | DOAJ |
| description | Aim. To evaluate the kidney status from osmotic urine concentration in different stages of diabetes mellitus (DM) to define whether not only glomeruli and proximal tubules, but also renal medullary substance structures are involved into the pathological process, as well as their reaction to endogenous vasopressin production.
Subjects and methods. Forty patients with a 1-to-28-year history of DM, including 18 with diabetic nephropathy, 10 with chronic renal failure, and 22 without diabetic nephropathy, were examined. Urine and blood osmolality were determined and renal osmoregulating function was estimated.
Results. Decreased glomerular filtration rate was found in relation to the duration of DM. The osmolality of nocturnal urine samples tended to diminish during short-term deprivation depending on the duration of DM. Increased diuresis in DM was shown to correlate with the higher reabsorption of osmotically free water.
Conclusion. Diminished renal concentrating capacity in DM appears to depend on evolving renal failure rather than vasopressin resistance. The application of a new approach, by calculating the clearance of sodium-free water, suggests that its increased reabsorption favors normalization of serum osmolality in hyperglycemia. |
| first_indexed | 2024-04-12T04:53:00Z |
| format | Article |
| id | doaj.art-e33bade196f84501aebeff3c37503c74 |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-04-12T04:53:00Z |
| publishDate | 2010-06-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-e33bade196f84501aebeff3c37503c742022-12-22T03:47:15Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422010-06-0182691427602Diabetes mellitus: renal osmoregulating functionYu V Natochin0M V Shestakova1A A Kuznetsova2I I Klefortova3N P Trubitsyna4I I Dedov5I. M. Sechenov Institute of Evolution Physiology and Biochemistry, Russian Academy of Sciences, Saint PetersburgEndocrinology Research Center, Russian Agency for Medical Technologies, MoscowI. M. Sechenov Institute of Evolution Physiology and Biochemistry, Russian Academy of Sciences, Saint PetersburgEndocrinology Research Center, Russian Agency for Medical Technologies, MoscowEndocrinology Research Center, Russian Agency for Medical Technologies, MoscowEndocrinology Research Center, Russian Agency for Medical Technologies, MoscowAim. To evaluate the kidney status from osmotic urine concentration in different stages of diabetes mellitus (DM) to define whether not only glomeruli and proximal tubules, but also renal medullary substance structures are involved into the pathological process, as well as their reaction to endogenous vasopressin production. Subjects and methods. Forty patients with a 1-to-28-year history of DM, including 18 with diabetic nephropathy, 10 with chronic renal failure, and 22 without diabetic nephropathy, were examined. Urine and blood osmolality were determined and renal osmoregulating function was estimated. Results. Decreased glomerular filtration rate was found in relation to the duration of DM. The osmolality of nocturnal urine samples tended to diminish during short-term deprivation depending on the duration of DM. Increased diuresis in DM was shown to correlate with the higher reabsorption of osmotically free water. Conclusion. Diminished renal concentrating capacity in DM appears to depend on evolving renal failure rather than vasopressin resistance. The application of a new approach, by calculating the clearance of sodium-free water, suggests that its increased reabsorption favors normalization of serum osmolality in hyperglycemia.https://ter-arkhiv.ru/0040-3660/article/view/30575diabetes mellitusosmolalitydiabetic nephropathy |
| spellingShingle | Yu V Natochin M V Shestakova A A Kuznetsova I I Klefortova N P Trubitsyna I I Dedov Diabetes mellitus: renal osmoregulating function Терапевтический архив diabetes mellitus osmolality diabetic nephropathy |
| title | Diabetes mellitus: renal osmoregulating function |
| title_full | Diabetes mellitus: renal osmoregulating function |
| title_fullStr | Diabetes mellitus: renal osmoregulating function |
| title_full_unstemmed | Diabetes mellitus: renal osmoregulating function |
| title_short | Diabetes mellitus: renal osmoregulating function |
| title_sort | diabetes mellitus renal osmoregulating function |
| topic | diabetes mellitus osmolality diabetic nephropathy |
| url | https://ter-arkhiv.ru/0040-3660/article/view/30575 |
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