Strong decrease in streptomycin-resistance and absence of XDR 12 years after the Reorganization of the National Tuberculosis Control Program in the Central Region of Cameroon.
BACKGROUND: In the 1990s, resistance rates of 15% for streptomycin-resistance and 0.6% for multidrug-resistance (MDR) were reported from the Central Region of Cameroon. This work assesses drug resistant tuberculosis in this region 12 years after reorganization of the National Tuberculosis Control Pr...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4047025?pdf=render |
| _version_ | 1819065413395283968 |
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| author | Larissa Kamgue Sidze Emmanuel Mouafo Tekwu Christopher Kuaban Jean-Paul Assam Assam Jean-Claude Tedom Sara Eyangoh François-Xavier Fouda Désiré Nolna Francine Ntoumi Matthias Frank Véronique N Penlap Beng |
| author_facet | Larissa Kamgue Sidze Emmanuel Mouafo Tekwu Christopher Kuaban Jean-Paul Assam Assam Jean-Claude Tedom Sara Eyangoh François-Xavier Fouda Désiré Nolna Francine Ntoumi Matthias Frank Véronique N Penlap Beng |
| author_sort | Larissa Kamgue Sidze |
| collection | DOAJ |
| description | BACKGROUND: In the 1990s, resistance rates of 15% for streptomycin-resistance and 0.6% for multidrug-resistance (MDR) were reported from the Central Region of Cameroon. This work assesses drug resistant tuberculosis in this region 12 years after reorganization of the National Tuberculosis Control Program (NTCP). METHODS: This cross-sectional study was conducted from April 2010 to March 2011 in Jamot Hospital in Yaoundé, Cameroon. Only patients with smear positive pulmonary tuberculosis were included. Sputa were cultured and subsequently underwent drug susceptibility testing (DST). All consenting individuals were tested for their HIV status. RESULTS: A total of 665 smear positive pulmonary tuberculosis patients were enrolled. The HIV prevalence was 28.5% (95%CI [25.2-32.1]). Of the 582 sputa that grew Mycobacterium tuberculosis complex species, DST results were obtained for 576. The overall resistance rate was 10.9% (63/576). The overall resistance rates for single drug resistance were: isoniazid-resistance 4.7% (27/576), streptomycin-resistance 3.3% (19/576), rifampicin-resistance 0.2% (1/576), kanamycin-resistance 0.2% (1/576) and ofloxacin-resistance 0.2% (1/576). The MDR rate was 1.1% (6/576) and no extensively drug resistant tuberculosis (XDR) was detected. CONCLUSIONS: The data show that reorganization of the NTCP resulted in a strong decrease in streptomycin-resistance and suggest that it prevented the emergence of XDR in the Central Region of Cameroon. |
| first_indexed | 2024-12-21T15:46:04Z |
| format | Article |
| id | doaj.art-e33c32a082dc4beebb579bb818b9d6fc |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T15:46:04Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-e33c32a082dc4beebb579bb818b9d6fc2022-12-21T18:58:22ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0196e9837410.1371/journal.pone.0098374Strong decrease in streptomycin-resistance and absence of XDR 12 years after the Reorganization of the National Tuberculosis Control Program in the Central Region of Cameroon.Larissa Kamgue SidzeEmmanuel Mouafo TekwuChristopher KuabanJean-Paul Assam AssamJean-Claude TedomSara EyangohFrançois-Xavier FoudaDésiré NolnaFrancine NtoumiMatthias FrankVéronique N Penlap BengBACKGROUND: In the 1990s, resistance rates of 15% for streptomycin-resistance and 0.6% for multidrug-resistance (MDR) were reported from the Central Region of Cameroon. This work assesses drug resistant tuberculosis in this region 12 years after reorganization of the National Tuberculosis Control Program (NTCP). METHODS: This cross-sectional study was conducted from April 2010 to March 2011 in Jamot Hospital in Yaoundé, Cameroon. Only patients with smear positive pulmonary tuberculosis were included. Sputa were cultured and subsequently underwent drug susceptibility testing (DST). All consenting individuals were tested for their HIV status. RESULTS: A total of 665 smear positive pulmonary tuberculosis patients were enrolled. The HIV prevalence was 28.5% (95%CI [25.2-32.1]). Of the 582 sputa that grew Mycobacterium tuberculosis complex species, DST results were obtained for 576. The overall resistance rate was 10.9% (63/576). The overall resistance rates for single drug resistance were: isoniazid-resistance 4.7% (27/576), streptomycin-resistance 3.3% (19/576), rifampicin-resistance 0.2% (1/576), kanamycin-resistance 0.2% (1/576) and ofloxacin-resistance 0.2% (1/576). The MDR rate was 1.1% (6/576) and no extensively drug resistant tuberculosis (XDR) was detected. CONCLUSIONS: The data show that reorganization of the NTCP resulted in a strong decrease in streptomycin-resistance and suggest that it prevented the emergence of XDR in the Central Region of Cameroon.http://europepmc.org/articles/PMC4047025?pdf=render |
| spellingShingle | Larissa Kamgue Sidze Emmanuel Mouafo Tekwu Christopher Kuaban Jean-Paul Assam Assam Jean-Claude Tedom Sara Eyangoh François-Xavier Fouda Désiré Nolna Francine Ntoumi Matthias Frank Véronique N Penlap Beng Strong decrease in streptomycin-resistance and absence of XDR 12 years after the Reorganization of the National Tuberculosis Control Program in the Central Region of Cameroon. PLoS ONE |
| title | Strong decrease in streptomycin-resistance and absence of XDR 12 years after the Reorganization of the National Tuberculosis Control Program in the Central Region of Cameroon. |
| title_full | Strong decrease in streptomycin-resistance and absence of XDR 12 years after the Reorganization of the National Tuberculosis Control Program in the Central Region of Cameroon. |
| title_fullStr | Strong decrease in streptomycin-resistance and absence of XDR 12 years after the Reorganization of the National Tuberculosis Control Program in the Central Region of Cameroon. |
| title_full_unstemmed | Strong decrease in streptomycin-resistance and absence of XDR 12 years after the Reorganization of the National Tuberculosis Control Program in the Central Region of Cameroon. |
| title_short | Strong decrease in streptomycin-resistance and absence of XDR 12 years after the Reorganization of the National Tuberculosis Control Program in the Central Region of Cameroon. |
| title_sort | strong decrease in streptomycin resistance and absence of xdr 12 years after the reorganization of the national tuberculosis control program in the central region of cameroon |
| url | http://europepmc.org/articles/PMC4047025?pdf=render |
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