Regulation of T Helper Cell Fate by TCR Signal Strength
T cells are critical in orchestrating protective immune responses to cancer and an array of pathogens. The interaction between a peptide MHC (pMHC) complex on antigen presenting cells (APCs) and T cell receptors (TCRs) on T cells initiates T cell activation, division, and clonal expansion in seconda...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-05-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2020.00624/full |
| _version_ | 1828491977982738432 |
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| author | Nayan D. Bhattacharyya Nayan D. Bhattacharyya Carl G. Feng Carl G. Feng |
| author_facet | Nayan D. Bhattacharyya Nayan D. Bhattacharyya Carl G. Feng Carl G. Feng |
| author_sort | Nayan D. Bhattacharyya |
| collection | DOAJ |
| description | T cells are critical in orchestrating protective immune responses to cancer and an array of pathogens. The interaction between a peptide MHC (pMHC) complex on antigen presenting cells (APCs) and T cell receptors (TCRs) on T cells initiates T cell activation, division, and clonal expansion in secondary lymphoid organs. T cells must also integrate multiple T cell-intrinsic and extrinsic signals to acquire the effector functions essential for the defense against invading microbes. In the case of T helper cell differentiation, while innate cytokines have been demonstrated to shape effector CD4+ T lymphocyte function, the contribution of TCR signaling strength to T helper cell differentiation is less understood. In this review, we summarize the signaling cascades regulated by the strength of TCR stimulation. Various mechanisms in which TCR signal strength controls T helper cell expansion and differentiation are also discussed. |
| first_indexed | 2024-12-11T11:12:23Z |
| format | Article |
| id | doaj.art-e33e36b025ac4ddbbaef4e900e6f34a2 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-11T11:12:23Z |
| publishDate | 2020-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-e33e36b025ac4ddbbaef4e900e6f34a22022-12-22T01:09:29ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-05-011110.3389/fimmu.2020.00624522539Regulation of T Helper Cell Fate by TCR Signal StrengthNayan D. Bhattacharyya0Nayan D. Bhattacharyya1Carl G. Feng2Carl G. Feng3Immunology and Host Defense Group, Discipline of Infectious Diseases and Immunology, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, AustraliaTuberculosis Research Program, Centenary Institute, The University of Sydney, Sydney, NSW, AustraliaImmunology and Host Defense Group, Discipline of Infectious Diseases and Immunology, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, AustraliaTuberculosis Research Program, Centenary Institute, The University of Sydney, Sydney, NSW, AustraliaT cells are critical in orchestrating protective immune responses to cancer and an array of pathogens. The interaction between a peptide MHC (pMHC) complex on antigen presenting cells (APCs) and T cell receptors (TCRs) on T cells initiates T cell activation, division, and clonal expansion in secondary lymphoid organs. T cells must also integrate multiple T cell-intrinsic and extrinsic signals to acquire the effector functions essential for the defense against invading microbes. In the case of T helper cell differentiation, while innate cytokines have been demonstrated to shape effector CD4+ T lymphocyte function, the contribution of TCR signaling strength to T helper cell differentiation is less understood. In this review, we summarize the signaling cascades regulated by the strength of TCR stimulation. Various mechanisms in which TCR signal strength controls T helper cell expansion and differentiation are also discussed.https://www.frontiersin.org/article/10.3389/fimmu.2020.00624/fullTCR signal strengthTCR affinityAntigen doseCD4+ T Cell differentiationT cell expansionT cell proliferation |
| spellingShingle | Nayan D. Bhattacharyya Nayan D. Bhattacharyya Carl G. Feng Carl G. Feng Regulation of T Helper Cell Fate by TCR Signal Strength Frontiers in Immunology TCR signal strength TCR affinity Antigen dose CD4+ T Cell differentiation T cell expansion T cell proliferation |
| title | Regulation of T Helper Cell Fate by TCR Signal Strength |
| title_full | Regulation of T Helper Cell Fate by TCR Signal Strength |
| title_fullStr | Regulation of T Helper Cell Fate by TCR Signal Strength |
| title_full_unstemmed | Regulation of T Helper Cell Fate by TCR Signal Strength |
| title_short | Regulation of T Helper Cell Fate by TCR Signal Strength |
| title_sort | regulation of t helper cell fate by tcr signal strength |
| topic | TCR signal strength TCR affinity Antigen dose CD4+ T Cell differentiation T cell expansion T cell proliferation |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2020.00624/full |
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