Cardiac troponins and coronary artery calcium score: a systematic review
Abstract An early diagnosis of atherosclerosis, particularly in subclinical status, can play a remarkable role in reducing mortality and morbidity. Because of coronary artery calcification (CAC) nature in radiation exposure, finding biomarkers associated with CAC could be useful in identifying indiv...
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | BMC Cardiovascular Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12872-024-03761-x |
| _version_ | 1827328719714254848 |
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| author | Naghmeh Shahraki Sara Samadi Omid Arasteh Reza Javidi Dashtbayaz Batool Zarei Amir Hooshang Mohammadpour Vahid Jomehzadeh |
| author_facet | Naghmeh Shahraki Sara Samadi Omid Arasteh Reza Javidi Dashtbayaz Batool Zarei Amir Hooshang Mohammadpour Vahid Jomehzadeh |
| author_sort | Naghmeh Shahraki |
| collection | DOAJ |
| description | Abstract An early diagnosis of atherosclerosis, particularly in subclinical status, can play a remarkable role in reducing mortality and morbidity. Because of coronary artery calcification (CAC) nature in radiation exposure, finding biomarkers associated with CAC could be useful in identifying individuals at high risk of CAC score. In this review, we focused on the association of cardiac troponins (hs-cTns) and CAC to achieve insight into the pathophysiology of CAC. In October 2022, we systematically searched Web of Science, Scopus, PubMed, and Embase databases to find human observational studies which have investigated the association of CAC with cardiac troponins. To appraise the included articles, we used the Newcastle Ottawa scale (NOS). Out of 520 records, 10 eligible studies were included. Based on findings from longitudinal studies and cross-sectional analyses, troponin T and I were correlated with occurrence of CAC and its severity. Two of the most important risk factors that affect the correlation between hs-cTns serum levels and CAC were age and gender. The elevation of cardiac troponins may affect the progression of CAC and future cardiovascular diseases. Verifying the association between cardiac troponins and CAC may lead to identify individuals exposed to enhanced risk of cardiovascular disease (CVD) complications and could establish innovative targets for pharmacological therapy. |
| first_indexed | 2024-03-07T15:21:23Z |
| format | Article |
| id | doaj.art-e33e61d20e8f473bb57cf2cb6cd3f2ee |
| institution | Directory Open Access Journal |
| issn | 1471-2261 |
| language | English |
| last_indexed | 2024-03-07T15:21:23Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cardiovascular Disorders |
| spelling | doaj.art-e33e61d20e8f473bb57cf2cb6cd3f2ee2024-03-05T17:37:46ZengBMCBMC Cardiovascular Disorders1471-22612024-02-0124111110.1186/s12872-024-03761-xCardiac troponins and coronary artery calcium score: a systematic reviewNaghmeh Shahraki0Sara Samadi1Omid Arasteh2Reza Javidi Dashtbayaz3Batool Zarei4Amir Hooshang Mohammadpour5Vahid Jomehzadeh6Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical SciencesDepartment of Internal Medicine, Faculty of Medicine, Mashhad University of Medical SciencesDepartment of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical SciencesDepartment of cardiovascular diseases, Faculty of Medicine, Mashhad University of Medical SciencesDepartment of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical SciencesDepartment of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical SciencesDepartment of Surgery, Faculty of Medicine, Mashhad University of Medical SciencesAbstract An early diagnosis of atherosclerosis, particularly in subclinical status, can play a remarkable role in reducing mortality and morbidity. Because of coronary artery calcification (CAC) nature in radiation exposure, finding biomarkers associated with CAC could be useful in identifying individuals at high risk of CAC score. In this review, we focused on the association of cardiac troponins (hs-cTns) and CAC to achieve insight into the pathophysiology of CAC. In October 2022, we systematically searched Web of Science, Scopus, PubMed, and Embase databases to find human observational studies which have investigated the association of CAC with cardiac troponins. To appraise the included articles, we used the Newcastle Ottawa scale (NOS). Out of 520 records, 10 eligible studies were included. Based on findings from longitudinal studies and cross-sectional analyses, troponin T and I were correlated with occurrence of CAC and its severity. Two of the most important risk factors that affect the correlation between hs-cTns serum levels and CAC were age and gender. The elevation of cardiac troponins may affect the progression of CAC and future cardiovascular diseases. Verifying the association between cardiac troponins and CAC may lead to identify individuals exposed to enhanced risk of cardiovascular disease (CVD) complications and could establish innovative targets for pharmacological therapy.https://doi.org/10.1186/s12872-024-03761-xTroponin TTroponin ICardiac troponinsCoronary calcium scoreCACAtherosclerosis |
| spellingShingle | Naghmeh Shahraki Sara Samadi Omid Arasteh Reza Javidi Dashtbayaz Batool Zarei Amir Hooshang Mohammadpour Vahid Jomehzadeh Cardiac troponins and coronary artery calcium score: a systematic review BMC Cardiovascular Disorders Troponin T Troponin I Cardiac troponins Coronary calcium score CAC Atherosclerosis |
| title | Cardiac troponins and coronary artery calcium score: a systematic review |
| title_full | Cardiac troponins and coronary artery calcium score: a systematic review |
| title_fullStr | Cardiac troponins and coronary artery calcium score: a systematic review |
| title_full_unstemmed | Cardiac troponins and coronary artery calcium score: a systematic review |
| title_short | Cardiac troponins and coronary artery calcium score: a systematic review |
| title_sort | cardiac troponins and coronary artery calcium score a systematic review |
| topic | Troponin T Troponin I Cardiac troponins Coronary calcium score CAC Atherosclerosis |
| url | https://doi.org/10.1186/s12872-024-03761-x |
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