Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer’s disease

Long-term effects of immunotherapy with a brain penetrating Aβ antibody in a mouse model of Alzheimer’s disease

Abstract Background Brain-directed immunotherapy is a promising strategy to target amyloid-β (Aβ) deposits in Alzheimer’s disease (AD). In the present study, we compared the therapeutic efficacy of the Aβ protofibril targeting antibody RmAb158 with its bispecific variant RmAb158-scFv8D3, which enter...

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Bibliographic Details
Main Authors: Tobias Gustavsson, Nicole G. Metzendorf, Elin Wik, Sahar Roshanbin, Ulrika Julku, Aikaterini Chourlia, Per Nilsson, Ken G. Andersson, Hanna Laudon, Greta Hultqvist, Stina Syvänen, Dag Sehlin
Format: Article
Language:English
Published: BMC 2023-05-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease (AD)
Immunotherapy
Amyloid-β (Aβ)
Monoclonal antibody
Blood–brain barrier (BBB)
Transferrin receptor (TfR)-mediated transcytosis
Online Access:https://doi.org/10.1186/s13195-023-01236-3

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https://doi.org/10.1186/s13195-023-01236-3

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