Cholangioscopy and its Role in Primary Sclerosing Cholangitis
Primary sclerosing cholangitis (PSC) is a cholestatic liver disease characterised by chronic inflammation and fibro-obliteration of the intrahepatic and/or extrahepatic bile ducts. It is associated with numerous hepatobiliary complications including an increased risk of malignancy (in particular,...
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| Format: | Article |
| Language: | English |
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European Medical Journal
2020-06-01
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| Series: | European Medical Journal Hepatology |
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| Online Access: | https://www.emjreviews.com/hepatology/article/cholangioscopy-and-its-role-in-primary-sclerosing-cholangitis/ |
| _version_ | 1818501240960581632 |
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| author | Brian M. Fung M. Phillip Fejleh Sooraj Tejaswi James H. Tabibian |
| author_facet | Brian M. Fung M. Phillip Fejleh Sooraj Tejaswi James H. Tabibian |
| author_sort | Brian M. Fung |
| collection | DOAJ |
| description | Primary sclerosing cholangitis (PSC) is a cholestatic liver disease characterised by chronic
inflammation and fibro-obliteration of the intrahepatic and/or extrahepatic bile ducts. It is
associated with numerous hepatobiliary complications including an increased risk of malignancy (in
particular, cholangiocarcinoma) and biliary tract stone formation. The evaluation of biliary strictures
in patients with PSC is especially challenging, with imaging and endoscopic methods having only
modest sensitivity for the diagnosis of cholangiocarcinoma, and treatment of biliary strictures
poses a similarly significant clinical challenge. In recent years, peroral cholangioscopy has evolved
technologically and increased in popularity as an endoscopic tool that can provide direct intraductal
visualisation and facilitate therapeutic manipulation of the biliary tract. However, the indications for
and effectiveness of its use in patients with PSC remain uncertain, with only a few studies performed
on this small but important subset of patients. In this review, the authors discuss the available data
regarding the use of peroral cholangioscopy in patients with PSC, with a focus on its use in the
evaluation and management of biliary strictures and stones. |
| first_indexed | 2024-12-10T20:53:29Z |
| format | Article |
| id | doaj.art-e34050cedfde4b5eb2adc1065f4af7d4 |
| institution | Directory Open Access Journal |
| issn | 2053-4221 |
| language | English |
| last_indexed | 2024-12-10T20:53:29Z |
| publishDate | 2020-06-01 |
| publisher | European Medical Journal |
| record_format | Article |
| series | European Medical Journal Hepatology |
| spelling | doaj.art-e34050cedfde4b5eb2adc1065f4af7d42022-12-22T01:34:02ZengEuropean Medical JournalEuropean Medical Journal Hepatology2053-42212020-06-01814253Cholangioscopy and its Role in Primary Sclerosing CholangitisBrian M. Fung0M. Phillip Fejleh1Sooraj Tejaswi2James H. Tabibian3Department of Medicine, Olive View-UCLA Medical Center, Los Angeles, California, USA; David Geffen School of Medicine at UCLA, Los Angeles, California, USAVatche and Tamar Manoukian Division of Digestive Diseases, David Geffen School of Medicine at UCLA, Los Angeles, California, USADivision of Gastroenterology & Hepatology, University of California, UC Davis Health, Sacramento, California, USADavid Geffen School of Medicine at UCLA, Los Angeles, California, USA; Division of Gastroenterology, Department of Medicine, Olive View-UCLA Medical Center, Los Angeles, California, USAPrimary sclerosing cholangitis (PSC) is a cholestatic liver disease characterised by chronic inflammation and fibro-obliteration of the intrahepatic and/or extrahepatic bile ducts. It is associated with numerous hepatobiliary complications including an increased risk of malignancy (in particular, cholangiocarcinoma) and biliary tract stone formation. The evaluation of biliary strictures in patients with PSC is especially challenging, with imaging and endoscopic methods having only modest sensitivity for the diagnosis of cholangiocarcinoma, and treatment of biliary strictures poses a similarly significant clinical challenge. In recent years, peroral cholangioscopy has evolved technologically and increased in popularity as an endoscopic tool that can provide direct intraductal visualisation and facilitate therapeutic manipulation of the biliary tract. However, the indications for and effectiveness of its use in patients with PSC remain uncertain, with only a few studies performed on this small but important subset of patients. In this review, the authors discuss the available data regarding the use of peroral cholangioscopy in patients with PSC, with a focus on its use in the evaluation and management of biliary strictures and stones.https://www.emjreviews.com/hepatology/article/cholangioscopy-and-its-role-in-primary-sclerosing-cholangitis/biliary stricturecholangiocarcinoma (cca)cholangioscopy-guided biopsycholangioscopy-guided lithotripsydominant strictureperoral cholangioscopy (poc)single-operator cholangioscopy (soc) |
| spellingShingle | Brian M. Fung M. Phillip Fejleh Sooraj Tejaswi James H. Tabibian Cholangioscopy and its Role in Primary Sclerosing Cholangitis European Medical Journal Hepatology biliary stricture cholangiocarcinoma (cca) cholangioscopy-guided biopsy cholangioscopy-guided lithotripsy dominant stricture peroral cholangioscopy (poc) single-operator cholangioscopy (soc) |
| title | Cholangioscopy and its Role in Primary Sclerosing Cholangitis |
| title_full | Cholangioscopy and its Role in Primary Sclerosing Cholangitis |
| title_fullStr | Cholangioscopy and its Role in Primary Sclerosing Cholangitis |
| title_full_unstemmed | Cholangioscopy and its Role in Primary Sclerosing Cholangitis |
| title_short | Cholangioscopy and its Role in Primary Sclerosing Cholangitis |
| title_sort | cholangioscopy and its role in primary sclerosing cholangitis |
| topic | biliary stricture cholangiocarcinoma (cca) cholangioscopy-guided biopsy cholangioscopy-guided lithotripsy dominant stricture peroral cholangioscopy (poc) single-operator cholangioscopy (soc) |
| url | https://www.emjreviews.com/hepatology/article/cholangioscopy-and-its-role-in-primary-sclerosing-cholangitis/ |
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