Targeted Stimuli-Responsive Mesoporous Silica Nanoparticles for Bacterial Infection Treatment
The rise of antibiotic resistance and the growing number of biofilm-related infections make bacterial infections a serious threat for global human health. Nanomedicine has entered into this scenario by bringing new alternatives to design and develop effective antimicrobial nanoweapons to fight again...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-11-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/21/22/8605 |
| _version_ | 1797547857775951872 |
|---|---|
| author | Montserrat Colilla María Vallet-Regí |
| author_facet | Montserrat Colilla María Vallet-Regí |
| author_sort | Montserrat Colilla |
| collection | DOAJ |
| description | The rise of antibiotic resistance and the growing number of biofilm-related infections make bacterial infections a serious threat for global human health. Nanomedicine has entered into this scenario by bringing new alternatives to design and develop effective antimicrobial nanoweapons to fight against bacterial infection. Among them, mesoporous silica nanoparticles (MSNs) exhibit unique characteristics that make them ideal nanocarriers to load, protect and transport antimicrobial cargoes to the target bacteria and/or biofilm, and release them in response to certain stimuli. The combination of infection-targeting and stimuli-responsive drug delivery capabilities aims to increase the specificity and efficacy of antimicrobial treatment and prevent undesirable side effects, becoming a ground-breaking alternative to conventional antibiotic treatments. This review focuses on the scientific advances developed to date in MSNs for infection-targeted stimuli-responsive antimicrobials delivery. The targeting strategies for specific recognition of bacteria are detailed. Moreover, the possibility of incorporating anti-biofilm agents with MSNs aimed at promoting biofilm penetrability is overviewed. Finally, a comprehensive description of the different scientific approaches for the design and development of smart MSNs able to release the antimicrobial payloads at the infection site in response to internal or external stimuli is provided. |
| first_indexed | 2024-03-10T14:51:17Z |
| format | Article |
| id | doaj.art-e34139c2276b4b3aa1c35f34e1ea9383 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T14:51:17Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-e34139c2276b4b3aa1c35f34e1ea93832023-11-20T21:01:38ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-11-012122860510.3390/ijms21228605Targeted Stimuli-Responsive Mesoporous Silica Nanoparticles for Bacterial Infection TreatmentMontserrat Colilla0María Vallet-Regí1Departamento de Química en Ciencias Farmacéuticas, Unidad de Química Inorgánica y Bioinorgánica, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Hospital 12 de Octubre i+12, Plaza Ramón y Cajal s/n, 28040 Madrid, SpainDepartamento de Química en Ciencias Farmacéuticas, Unidad de Química Inorgánica y Bioinorgánica, Universidad Complutense de Madrid, Instituto de Investigación Sanitaria Hospital 12 de Octubre i+12, Plaza Ramón y Cajal s/n, 28040 Madrid, SpainThe rise of antibiotic resistance and the growing number of biofilm-related infections make bacterial infections a serious threat for global human health. Nanomedicine has entered into this scenario by bringing new alternatives to design and develop effective antimicrobial nanoweapons to fight against bacterial infection. Among them, mesoporous silica nanoparticles (MSNs) exhibit unique characteristics that make them ideal nanocarriers to load, protect and transport antimicrobial cargoes to the target bacteria and/or biofilm, and release them in response to certain stimuli. The combination of infection-targeting and stimuli-responsive drug delivery capabilities aims to increase the specificity and efficacy of antimicrobial treatment and prevent undesirable side effects, becoming a ground-breaking alternative to conventional antibiotic treatments. This review focuses on the scientific advances developed to date in MSNs for infection-targeted stimuli-responsive antimicrobials delivery. The targeting strategies for specific recognition of bacteria are detailed. Moreover, the possibility of incorporating anti-biofilm agents with MSNs aimed at promoting biofilm penetrability is overviewed. Finally, a comprehensive description of the different scientific approaches for the design and development of smart MSNs able to release the antimicrobial payloads at the infection site in response to internal or external stimuli is provided.https://www.mdpi.com/1422-0067/21/22/8605mesoporous silica nanoparticlesbacterial infectionbacterial resistancebiofilmtargetingantimicrobials |
| spellingShingle | Montserrat Colilla María Vallet-Regí Targeted Stimuli-Responsive Mesoporous Silica Nanoparticles for Bacterial Infection Treatment International Journal of Molecular Sciences mesoporous silica nanoparticles bacterial infection bacterial resistance biofilm targeting antimicrobials |
| title | Targeted Stimuli-Responsive Mesoporous Silica Nanoparticles for Bacterial Infection Treatment |
| title_full | Targeted Stimuli-Responsive Mesoporous Silica Nanoparticles for Bacterial Infection Treatment |
| title_fullStr | Targeted Stimuli-Responsive Mesoporous Silica Nanoparticles for Bacterial Infection Treatment |
| title_full_unstemmed | Targeted Stimuli-Responsive Mesoporous Silica Nanoparticles for Bacterial Infection Treatment |
| title_short | Targeted Stimuli-Responsive Mesoporous Silica Nanoparticles for Bacterial Infection Treatment |
| title_sort | targeted stimuli responsive mesoporous silica nanoparticles for bacterial infection treatment |
| topic | mesoporous silica nanoparticles bacterial infection bacterial resistance biofilm targeting antimicrobials |
| url | https://www.mdpi.com/1422-0067/21/22/8605 |
| work_keys_str_mv | AT montserratcolilla targetedstimuliresponsivemesoporoussilicananoparticlesforbacterialinfectiontreatment AT mariavalletregi targetedstimuliresponsivemesoporoussilicananoparticlesforbacterialinfectiontreatment |