Increased NLRP1 mRNA and Protein Expression Suggests Inflammasome Activation in the Dorsolateral Prefrontal and Medial Orbitofrontal Cortex in Schizophrenia

Increased NLRP1 mRNA and Protein Expression Suggests Inflammasome Activation in the Dorsolateral Prefrontal and Medial Orbitofrontal Cortex in Schizophrenia

Schizophrenia is a complex mental condition, with key symptoms marked for diagnosis including delusions, hallucinations, disorganized thinking, reduced emotional expression, and social dysfunction. In the context of major developmental hypotheses of schizophrenia, notably those concerning maternal i...

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Bibliographic Details
Main Authors: Ena Španić Popovački, Dora Vogrinc, Heidi R. Fuller, Lea Langer Horvat, Davor Mayer, Janja Kopić, Klara Pintarić, Mirjana Babić Leko, Mihaela Pravica, Željka Krsnik, Darko Marčinko, Marina Šagud, Patrick R. Hof, Mihovil Mladinov, Goran Šimić
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Biomolecules
Subjects:
schizophrenia
NLRP1 inflammasome
predictive processing
prefrontal cortex
pyramidal neurons
Online Access:https://www.mdpi.com/2218-273X/14/3/302

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