Systems Biology of Yersinia pestis
Omics technologies developed in recent years significantly changed our approach in study molecular biology of bacterial pathogens. The research now can be conducted at a whole-genome level enabling us to simultaneously measure variable components, such as proteins, nucleic acids, metabolites, cell l...
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| Format: | Article |
| Language: | Russian |
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Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe”
2013-09-01
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| Series: | Проблемы особо опасных инфекций |
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| Online Access: | https://journal.microbe.ru/jour/article/view/61 |
| Summary: | Omics technologies developed in recent years significantly changed our approach in study molecular biology of bacterial pathogens. The research now can be conducted at a whole-genome level enabling us to simultaneously measure variable components, such as proteins, nucleic acids, metabolites, cell lipid composition, etc . This complex work requires a constant interaction of multi-disciplinary experts to integrate biology, instrumentation and computational science. A multi-omics research (transcriptomics, proteomics, metabolomics) was applied to Y. pestis -centric system biology study. Integrated omics datasets allowed to refine genome annotations, discover novel putative virulence factors, build regulatory networks, and create an interactive computational metabolic model. |
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| ISSN: | 0370-1069 2658-719X |