Exophiala dermatitidis pneumonia with bronchiectasis required prolonged voriconazole treatment
Abstract Exophiala dermatitidis is a black fungus that rarely causes respiratory infection. We report a case of E. dermatitidis pneumonia with bronchiectasis that relapsed after 11 months of voriconazole (VRCZ) treatment in a rheumatoid arthritis (RA) patient with bronchiectasis. A 65‐year‐old woman...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-06-01
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| Series: | Respirology Case Reports |
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| Online Access: | https://doi.org/10.1002/rcr2.783 |
| _version_ | 1818726401190133760 |
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| author | Ryo Sekiguchi Naohisa Urabe Susumu Sakamoto Masakazu Sasaki Sakae Homma Kazuma Kishi |
| author_facet | Ryo Sekiguchi Naohisa Urabe Susumu Sakamoto Masakazu Sasaki Sakae Homma Kazuma Kishi |
| author_sort | Ryo Sekiguchi |
| collection | DOAJ |
| description | Abstract Exophiala dermatitidis is a black fungus that rarely causes respiratory infection. We report a case of E. dermatitidis pneumonia with bronchiectasis that relapsed after 11 months of voriconazole (VRCZ) treatment in a rheumatoid arthritis (RA) patient with bronchiectasis. A 65‐year‐old woman with RA and abnormal findings on chest radiography was referred for assessment of chronic cough and increased sputum production. She underwent bronchoscopy, and E. dermatitidis was identified from bronchoalveolar lavage fluid (BALF). Exophiala dermatitidis chronic lower respiratory tract infection and pneumonia were diagnosed. Although her condition improved after 11 months of VRCZ treatment, chest computed tomography (CT) images showed worsening at five months after the cessation of VRCZ treatment and E. dermatitidis was again detected in BALF. Re‐administration of VRCZ for two years improved symptoms and chest CT images, and her condition is currently stable. In patients with bronchiectasis, E. dermatitidis pneumonia might require prolonged antifungal treatment. |
| first_indexed | 2024-12-17T21:57:37Z |
| format | Article |
| id | doaj.art-e342febec31f451ba3eb89c9739f59c8 |
| institution | Directory Open Access Journal |
| issn | 2051-3380 |
| language | English |
| last_indexed | 2024-12-17T21:57:37Z |
| publishDate | 2021-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Respirology Case Reports |
| spelling | doaj.art-e342febec31f451ba3eb89c9739f59c82022-12-21T21:31:04ZengWileyRespirology Case Reports2051-33802021-06-0196n/an/a10.1002/rcr2.783Exophiala dermatitidis pneumonia with bronchiectasis required prolonged voriconazole treatmentRyo Sekiguchi0Naohisa Urabe1Susumu Sakamoto2Masakazu Sasaki3Sakae Homma4Kazuma Kishi5Department of Respiratory Medicine Toho University Omori Medical Center Tokyo JapanDepartment of Respiratory Medicine Toho University Omori Medical Center Tokyo JapanDepartment of Respiratory Medicine Toho University Omori Medical Center Tokyo JapanDepartment of Clinical Laboratory Toho University Omori Medical Center Tokyo JapanDepartment of Advanced and Integrated Interstitial Lung Disease Research Toho University School of Medicine Tokyo JapanDepartment of Respiratory Medicine Toho University Omori Medical Center Tokyo JapanAbstract Exophiala dermatitidis is a black fungus that rarely causes respiratory infection. We report a case of E. dermatitidis pneumonia with bronchiectasis that relapsed after 11 months of voriconazole (VRCZ) treatment in a rheumatoid arthritis (RA) patient with bronchiectasis. A 65‐year‐old woman with RA and abnormal findings on chest radiography was referred for assessment of chronic cough and increased sputum production. She underwent bronchoscopy, and E. dermatitidis was identified from bronchoalveolar lavage fluid (BALF). Exophiala dermatitidis chronic lower respiratory tract infection and pneumonia were diagnosed. Although her condition improved after 11 months of VRCZ treatment, chest computed tomography (CT) images showed worsening at five months after the cessation of VRCZ treatment and E. dermatitidis was again detected in BALF. Re‐administration of VRCZ for two years improved symptoms and chest CT images, and her condition is currently stable. In patients with bronchiectasis, E. dermatitidis pneumonia might require prolonged antifungal treatment.https://doi.org/10.1002/rcr2.783BronchiectasisExophiala dermatitidisnon‐cystic fibrosisvoriconazole |
| spellingShingle | Ryo Sekiguchi Naohisa Urabe Susumu Sakamoto Masakazu Sasaki Sakae Homma Kazuma Kishi Exophiala dermatitidis pneumonia with bronchiectasis required prolonged voriconazole treatment Respirology Case Reports Bronchiectasis Exophiala dermatitidis non‐cystic fibrosis voriconazole |
| title | Exophiala dermatitidis pneumonia with bronchiectasis required prolonged voriconazole treatment |
| title_full | Exophiala dermatitidis pneumonia with bronchiectasis required prolonged voriconazole treatment |
| title_fullStr | Exophiala dermatitidis pneumonia with bronchiectasis required prolonged voriconazole treatment |
| title_full_unstemmed | Exophiala dermatitidis pneumonia with bronchiectasis required prolonged voriconazole treatment |
| title_short | Exophiala dermatitidis pneumonia with bronchiectasis required prolonged voriconazole treatment |
| title_sort | exophiala dermatitidis pneumonia with bronchiectasis required prolonged voriconazole treatment |
| topic | Bronchiectasis Exophiala dermatitidis non‐cystic fibrosis voriconazole |
| url | https://doi.org/10.1002/rcr2.783 |
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