Genetic Ablation of miR-33 Increases Food Intake, Enhances Adipose Tissue Expansion, and Promotes Obesity and Insulin Resistance

Genetic Ablation of miR-33 Increases Food Intake, Enhances Adipose Tissue Expansion, and Promotes Obesity and Insulin Resistance

Summary: While therapeutic modulation of miRNAs provides a promising approach for numerous diseases, the promiscuous nature of miRNAs raises concern over detrimental off-target effects. miR-33 has emerged as a likely target for treatment of cardiovascular diseases. However, the deleterious effects o...

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Bibliographic Details
Main Authors: Nathan L. Price, Abhishek K. Singh, Noemi Rotllan, Leigh Goedeke, Allison Wing, Alberto Canfrán-Duque, Alberto Diaz-Ruiz, Elisa Araldi, Ángel Baldán, Joao-Paulo Camporez, Yajaira Suárez, Matthew S. Rodeheffer, Gerald I. Shulman, Rafael de Cabo, Carlos Fernández-Hernando
Format: Article
Language:English
Published: Elsevier 2018-02-01
Series:Cell Reports
Subjects:
miR-33
obesity
insulin-resistance
food-consumption
metabolism
micro-RNA
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718301384

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