Mechanism of action of glycyrrhizin against Plasmodium falciparum
Extracts of the plant Glycyrrhiza glabra (licorice) are used in traditional medicine to treat malaria. The main active components are the saponin glycyrrhizin (GLR) and its active metabolite glycyrrhetinic acid (GA) which both display activities against Plasmodium falciparum. We have identified thre...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2021-08-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762021000100205&tlng=en |
| _version_ | 1797718190800764928 |
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| author | Maria de Nazaré Correia Soeiro Gérard Vergoten Christian Bailly |
| author_facet | Maria de Nazaré Correia Soeiro Gérard Vergoten Christian Bailly |
| author_sort | Maria de Nazaré Correia Soeiro |
| collection | DOAJ |
| description | Extracts of the plant Glycyrrhiza glabra (licorice) are used in traditional medicine to treat malaria. The main active components are the saponin glycyrrhizin (GLR) and its active metabolite glycyrrhetinic acid (GA) which both display activities against Plasmodium falciparum. We have identified three main mechanisms at the origin of their anti-plasmodial activity: (i) drug-induced disorganisation of membrane lipid rafts, (ii) blockade of the alarmin protein HMGB1 and (iii) potential inhibition of the detoxifying enzyme glyoxalase 1 (GLO-1) considered as an important drug target for malaria. Our analysis shed light on the mechanism of action of GLR against P. falciparum. |
| first_indexed | 2024-03-12T08:47:17Z |
| format | Article |
| id | doaj.art-e3453054122c45419476d86bb8b7fc9c |
| institution | Directory Open Access Journal |
| issn | 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T08:47:17Z |
| publishDate | 2021-08-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-e3453054122c45419476d86bb8b7fc9c2023-09-02T16:25:28ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz1678-80602021-08-0111610.1590/0074-02760210084Mechanism of action of glycyrrhizin against Plasmodium falciparumMaria de Nazaré Correia SoeiroGérard VergotenChristian Baillyhttps://orcid.org/0000-0002-2973-9357Extracts of the plant Glycyrrhiza glabra (licorice) are used in traditional medicine to treat malaria. The main active components are the saponin glycyrrhizin (GLR) and its active metabolite glycyrrhetinic acid (GA) which both display activities against Plasmodium falciparum. We have identified three main mechanisms at the origin of their anti-plasmodial activity: (i) drug-induced disorganisation of membrane lipid rafts, (ii) blockade of the alarmin protein HMGB1 and (iii) potential inhibition of the detoxifying enzyme glyoxalase 1 (GLO-1) considered as an important drug target for malaria. Our analysis shed light on the mechanism of action of GLR against P. falciparum.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762021000100205&tlng=encholesterolglycyrrhizinglyoxalase 1HMGB1MalariaPlasmodium |
| spellingShingle | Maria de Nazaré Correia Soeiro Gérard Vergoten Christian Bailly Mechanism of action of glycyrrhizin against Plasmodium falciparum Memorias do Instituto Oswaldo Cruz cholesterol glycyrrhizin glyoxalase 1 HMGB1 Malaria Plasmodium |
| title | Mechanism of action of glycyrrhizin against Plasmodium falciparum |
| title_full | Mechanism of action of glycyrrhizin against Plasmodium falciparum |
| title_fullStr | Mechanism of action of glycyrrhizin against Plasmodium falciparum |
| title_full_unstemmed | Mechanism of action of glycyrrhizin against Plasmodium falciparum |
| title_short | Mechanism of action of glycyrrhizin against Plasmodium falciparum |
| title_sort | mechanism of action of glycyrrhizin against plasmodium falciparum |
| topic | cholesterol glycyrrhizin glyoxalase 1 HMGB1 Malaria Plasmodium |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762021000100205&tlng=en |
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