Mechanism of action of glycyrrhizin against Plasmodium falciparum

Mechanism of action of glycyrrhizin against Plasmodium falciparum

Extracts of the plant Glycyrrhiza glabra (licorice) are used in traditional medicine to treat malaria. The main active components are the saponin glycyrrhizin (GLR) and its active metabolite glycyrrhetinic acid (GA) which both display activities against Plasmodium falciparum. We have identified thre...

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Bibliographic Details
Main Authors: Maria de Nazaré Correia Soeiro, Gérard Vergoten, Christian Bailly
Format: Article
Language:English
Published: Fundação Oswaldo Cruz (FIOCRUZ) 2021-08-01
Series:Memorias do Instituto Oswaldo Cruz
Subjects:
cholesterol
glycyrrhizin
glyoxalase 1
HMGB1
Malaria
Plasmodium
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762021000100205&tlng=en

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