Aggressive prostate cancer with somatic loss of the homologous recombination repair gene FANCA: a case report
Abstract Background Precision medicine based on genomic analysis of germline or tumor tissue is attracting attention. However, there is no consensus on how to apply the results of genomic analysis to treatment. Case presentation A 59-year-old man diagnosed with metastatic prostate cancer was diagnos...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-01-01
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| Series: | Diagnostic Pathology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13000-019-0916-z |
| _version_ | 1811270828758663168 |
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| author | Hiroshi Hongo Takeo Kosaka Eriko Aimono Hiroshi Nishihara Mototsugu Oya |
| author_facet | Hiroshi Hongo Takeo Kosaka Eriko Aimono Hiroshi Nishihara Mototsugu Oya |
| author_sort | Hiroshi Hongo |
| collection | DOAJ |
| description | Abstract Background Precision medicine based on genomic analysis of germline or tumor tissue is attracting attention. However, there is no consensus on how to apply the results of genomic analysis to treatment. Case presentation A 59-year-old man diagnosed with metastatic prostate cancer was diagnosed with castration-resistant prostate cancer. Although he was sequentially treated with enzalutamide and abiraterone, bone metastasis progression was identified by skeletal scintigraphy. Therefore, we sequentially performed docetaxel therapy followed by cabazitaxel. After the third cycle of cabazitaxel, his prostate-specific antigen level was stable at < 10 ng/mL, and no radiological progression was detected. The patient’s formalin-fixed paraffin-embedded tumor biopsy specimen underwent multiple-gene testing by next-generation sequencing, which identified a FANCA homodeletion. No significant germline mutation was observed. Conclusions We describe a case of aggressive, castration-resistant prostate cancer with FANCA homodeletion. Genomic analysis of prostate cancer tissue can be useful to determine optimal treatment of such cancers. |
| first_indexed | 2024-04-12T22:09:08Z |
| format | Article |
| id | doaj.art-e34530f1af0e439898e0b4712f6a85bd |
| institution | Directory Open Access Journal |
| issn | 1746-1596 |
| language | English |
| last_indexed | 2024-04-12T22:09:08Z |
| publishDate | 2020-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Diagnostic Pathology |
| spelling | doaj.art-e34530f1af0e439898e0b4712f6a85bd2022-12-22T03:14:50ZengBMCDiagnostic Pathology1746-15962020-01-011511410.1186/s13000-019-0916-zAggressive prostate cancer with somatic loss of the homologous recombination repair gene FANCA: a case reportHiroshi Hongo0Takeo Kosaka1Eriko Aimono2Hiroshi Nishihara3Mototsugu Oya4Department of Urology, Keio University School of MedicineDepartment of Urology, Keio University School of MedicineGenomics Unit, Keio Cancer Center, Keio University School of MedicineGenomics Unit, Keio Cancer Center, Keio University School of MedicineDepartment of Urology, Keio University School of MedicineAbstract Background Precision medicine based on genomic analysis of germline or tumor tissue is attracting attention. However, there is no consensus on how to apply the results of genomic analysis to treatment. Case presentation A 59-year-old man diagnosed with metastatic prostate cancer was diagnosed with castration-resistant prostate cancer. Although he was sequentially treated with enzalutamide and abiraterone, bone metastasis progression was identified by skeletal scintigraphy. Therefore, we sequentially performed docetaxel therapy followed by cabazitaxel. After the third cycle of cabazitaxel, his prostate-specific antigen level was stable at < 10 ng/mL, and no radiological progression was detected. The patient’s formalin-fixed paraffin-embedded tumor biopsy specimen underwent multiple-gene testing by next-generation sequencing, which identified a FANCA homodeletion. No significant germline mutation was observed. Conclusions We describe a case of aggressive, castration-resistant prostate cancer with FANCA homodeletion. Genomic analysis of prostate cancer tissue can be useful to determine optimal treatment of such cancers.https://doi.org/10.1186/s13000-019-0916-zFANCAHomologous recombination repairCastration-resistant prostate cancerNext-generation sequencingGenomic analysis |
| spellingShingle | Hiroshi Hongo Takeo Kosaka Eriko Aimono Hiroshi Nishihara Mototsugu Oya Aggressive prostate cancer with somatic loss of the homologous recombination repair gene FANCA: a case report Diagnostic Pathology FANCA Homologous recombination repair Castration-resistant prostate cancer Next-generation sequencing Genomic analysis |
| title | Aggressive prostate cancer with somatic loss of the homologous recombination repair gene FANCA: a case report |
| title_full | Aggressive prostate cancer with somatic loss of the homologous recombination repair gene FANCA: a case report |
| title_fullStr | Aggressive prostate cancer with somatic loss of the homologous recombination repair gene FANCA: a case report |
| title_full_unstemmed | Aggressive prostate cancer with somatic loss of the homologous recombination repair gene FANCA: a case report |
| title_short | Aggressive prostate cancer with somatic loss of the homologous recombination repair gene FANCA: a case report |
| title_sort | aggressive prostate cancer with somatic loss of the homologous recombination repair gene fanca a case report |
| topic | FANCA Homologous recombination repair Castration-resistant prostate cancer Next-generation sequencing Genomic analysis |
| url | https://doi.org/10.1186/s13000-019-0916-z |
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