Relevance of dietary protein concentration and quality as risk factors for the formation of calcium oxalate stones in cats
The role of dietary protein for the development of feline calcium oxalate (CaOx) uroliths has not been conclusively clarified. The present study evaluated the effects of a varying dietary protein concentration and quality on critical indices for the formation of CaOx uroliths. Three diets with a hig...
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Cambridge University Press
2014-01-01
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| Series: | Journal of Nutritional Science |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S2048679014000135/type/journal_article |
| _version_ | 1811156022920740864 |
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| author | Nadine Paßlack Hannes Burmeier Thomas Brenten Konrad Neumann Jürgen Zentek |
| author_facet | Nadine Paßlack Hannes Burmeier Thomas Brenten Konrad Neumann Jürgen Zentek |
| author_sort | Nadine Paßlack |
| collection | DOAJ |
| description | The role of dietary protein for the development of feline calcium oxalate (CaOx) uroliths has not been conclusively clarified. The present study evaluated the effects of a varying dietary protein concentration and quality on critical indices for the formation of CaOx uroliths. Three diets with a high protein quality (10–11 % greaves meal/diet) and a varying crude protein (CP) concentration (35, 44 and 57 % in DM) were compared. Additionally, the 57 % CP diet was compared with a fourth diet that had a similar CP concentration (55 % in DM), but a lower protein quality (34 % greaves meal/diet). The Ca and oxalate (Ox) concentrations were similar in all diets. A group of eight cats received the same diet at the same time. Each feeding period was divided into a 21 d adaptation period and a 7 d sampling period to collect urine. There were increases in urinary volume, urinary Ca concentrations, renal Ca and Ox excretion and urinary relative supersaturation (RSS) with CaOx with increasing dietary protein concentrations. Urinary pH ranged between 6·34 and 6·66 among all groups, with no unidirectional effect of dietary protein. Lower renal Ca excretion was observed when feeding the diet with the lower protein quality, however, the underlying mechanism needs further evaluation. In conclusion, although the observed higher urinary volume is beneficial, the increase in urinary Ca concentrations, renal Ca and Ox excretion and urinary RSS CaOx associated with a high-protein diet may be critical for the development of CaOx uroliths in cats. |
| first_indexed | 2024-04-10T04:44:30Z |
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| institution | Directory Open Access Journal |
| issn | 2048-6790 |
| language | English |
| last_indexed | 2024-04-10T04:44:30Z |
| publishDate | 2014-01-01 |
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| record_format | Article |
| series | Journal of Nutritional Science |
| spelling | doaj.art-e3485fe1c9f54383a766c50404511ea52023-03-09T12:38:43ZengCambridge University PressJournal of Nutritional Science2048-67902014-01-01310.1017/jns.2014.13Relevance of dietary protein concentration and quality as risk factors for the formation of calcium oxalate stones in catsNadine Paßlack0Hannes Burmeier1Thomas Brenten2Konrad Neumann3Jürgen Zentek4Institute of Animal Nutrition, Department of Veterinary Medicine, Freie Universität Berlin, Königin-Luise-Str. 49, 14195 Berlin, GermanyInstitute of Animal Nutrition, Department of Veterinary Medicine, Freie Universität Berlin, Königin-Luise-Str. 49, 14195 Berlin, GermanyMars GmbH, Eitzer Straße 215, 27283 Verden, GermanyInstitute of Biometry and Clinical Epidemiology, Charité – Universitätsmedizin Berlin, Hindenburgdamm 30, 12203 Berlin, GermanyInstitute of Animal Nutrition, Department of Veterinary Medicine, Freie Universität Berlin, Königin-Luise-Str. 49, 14195 Berlin, GermanyThe role of dietary protein for the development of feline calcium oxalate (CaOx) uroliths has not been conclusively clarified. The present study evaluated the effects of a varying dietary protein concentration and quality on critical indices for the formation of CaOx uroliths. Three diets with a high protein quality (10–11 % greaves meal/diet) and a varying crude protein (CP) concentration (35, 44 and 57 % in DM) were compared. Additionally, the 57 % CP diet was compared with a fourth diet that had a similar CP concentration (55 % in DM), but a lower protein quality (34 % greaves meal/diet). The Ca and oxalate (Ox) concentrations were similar in all diets. A group of eight cats received the same diet at the same time. Each feeding period was divided into a 21 d adaptation period and a 7 d sampling period to collect urine. There were increases in urinary volume, urinary Ca concentrations, renal Ca and Ox excretion and urinary relative supersaturation (RSS) with CaOx with increasing dietary protein concentrations. Urinary pH ranged between 6·34 and 6·66 among all groups, with no unidirectional effect of dietary protein. Lower renal Ca excretion was observed when feeding the diet with the lower protein quality, however, the underlying mechanism needs further evaluation. In conclusion, although the observed higher urinary volume is beneficial, the increase in urinary Ca concentrations, renal Ca and Ox excretion and urinary RSS CaOx associated with a high-protein diet may be critical for the development of CaOx uroliths in cats.https://www.cambridge.org/core/product/identifier/S2048679014000135/type/journal_articleCatsDietary proteinProtein qualityRenal calcium and oxalate excretionUrinary pH |
| spellingShingle | Nadine Paßlack Hannes Burmeier Thomas Brenten Konrad Neumann Jürgen Zentek Relevance of dietary protein concentration and quality as risk factors for the formation of calcium oxalate stones in cats Journal of Nutritional Science Cats Dietary protein Protein quality Renal calcium and oxalate excretion Urinary pH |
| title | Relevance of dietary protein concentration and quality as risk factors for the formation of calcium oxalate stones in cats |
| title_full | Relevance of dietary protein concentration and quality as risk factors for the formation of calcium oxalate stones in cats |
| title_fullStr | Relevance of dietary protein concentration and quality as risk factors for the formation of calcium oxalate stones in cats |
| title_full_unstemmed | Relevance of dietary protein concentration and quality as risk factors for the formation of calcium oxalate stones in cats |
| title_short | Relevance of dietary protein concentration and quality as risk factors for the formation of calcium oxalate stones in cats |
| title_sort | relevance of dietary protein concentration and quality as risk factors for the formation of calcium oxalate stones in cats |
| topic | Cats Dietary protein Protein quality Renal calcium and oxalate excretion Urinary pH |
| url | https://www.cambridge.org/core/product/identifier/S2048679014000135/type/journal_article |
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