Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression
Post-transcriptional control of RNA is important in health and disease. Here, the authors show that the RNA-binding protein Quaking guides pre-mRNA splicing and transcript abundance during monocyte to macrophage differentiation, and that Quaking depletion impairs pro-atherogenic foam cell formation.
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms10846 |
| _version_ | 1818842159257747456 |
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| author | Ruben G. de Bruin Lily Shiue Jurriën Prins Hetty C. de Boer Anjana Singh W. Samuel Fagg Janine M. van Gils Jacques M. G. J. Duijs Sol Katzman Adriaan O. Kraaijeveld Stefan Böhringer Wai Y. Leung Szymon M. Kielbasa John P. Donahue Patrick H.J. van der Zande Rick Sijbom Carla M. A. van Alem Ilze Bot Cees van Kooten J. Wouter Jukema Hilde Van Esch Ton J. Rabelink Hilal Kazan Erik A. L. Biessen Manuel Ares Jr. Anton Jan van Zonneveld Eric P. van der Veer |
| author_facet | Ruben G. de Bruin Lily Shiue Jurriën Prins Hetty C. de Boer Anjana Singh W. Samuel Fagg Janine M. van Gils Jacques M. G. J. Duijs Sol Katzman Adriaan O. Kraaijeveld Stefan Böhringer Wai Y. Leung Szymon M. Kielbasa John P. Donahue Patrick H.J. van der Zande Rick Sijbom Carla M. A. van Alem Ilze Bot Cees van Kooten J. Wouter Jukema Hilde Van Esch Ton J. Rabelink Hilal Kazan Erik A. L. Biessen Manuel Ares Jr. Anton Jan van Zonneveld Eric P. van der Veer |
| author_sort | Ruben G. de Bruin |
| collection | DOAJ |
| description | Post-transcriptional control of RNA is important in health and disease. Here, the authors show that the RNA-binding protein Quaking guides pre-mRNA splicing and transcript abundance during monocyte to macrophage differentiation, and that Quaking depletion impairs pro-atherogenic foam cell formation. |
| first_indexed | 2024-12-19T04:37:32Z |
| format | Article |
| id | doaj.art-e34ae01b9e3449c1bdf812e5f403f63e |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T04:37:32Z |
| publishDate | 2016-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-e34ae01b9e3449c1bdf812e5f403f63e2022-12-21T20:35:43ZengNature PortfolioNature Communications2041-17232016-03-017112010.1038/ncomms10846Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expressionRuben G. de Bruin0Lily Shiue1Jurriën Prins2Hetty C. de Boer3Anjana Singh4W. Samuel Fagg5Janine M. van Gils6Jacques M. G. J. Duijs7Sol Katzman8Adriaan O. Kraaijeveld9Stefan Böhringer10Wai Y. Leung11Szymon M. Kielbasa12John P. Donahue13Patrick H.J. van der Zande14Rick Sijbom15Carla M. A. van Alem16Ilze Bot17Cees van Kooten18J. Wouter Jukema19Hilde Van Esch20Ton J. Rabelink21Hilal Kazan22Erik A. L. Biessen23Manuel Ares Jr.24Anton Jan van Zonneveld25Eric P. van der Veer26Einthoven Laboratory of Experimental Vascular Medicine, Leiden University Medical CenterDepartment of Molecular, Center for Molecular Biology of RNA, Cell and Developmental Biology, University of CaliforniaEinthoven Laboratory of Experimental Vascular Medicine, Leiden University Medical CenterEinthoven Laboratory of Experimental Vascular Medicine, Leiden University Medical CenterDepartment of Pathology, CARIM, Academic University Hospital MaastrichtDepartment of Molecular, Center for Molecular Biology of RNA, Cell and Developmental Biology, University of CaliforniaEinthoven Laboratory of Experimental Vascular Medicine, Leiden University Medical CenterEinthoven Laboratory of Experimental Vascular Medicine, Leiden University Medical CenterDepartment of Molecular, Center for Molecular Biology of RNA, Cell and Developmental Biology, University of CaliforniaDepartment of Cardiology, Leiden University Medical CenterDepartment of Medical Biostatistics, Leiden University Medical CenterDepartment of Sequencing Analysis Support Core, Leiden University Medical CenterDepartment of Medical Biostatistics, Leiden University Medical CenterDepartment of Molecular, Center for Molecular Biology of RNA, Cell and Developmental Biology, University of CaliforniaEinthoven Laboratory of Experimental Vascular Medicine, Leiden University Medical CenterEinthoven Laboratory of Experimental Vascular Medicine, Leiden University Medical CenterDepartment of Internal Medicine (Nephrology), Leiden University Medical CenterDivision of Biopharmaceutics, Leiden/Amsterdam Center for Drug Research, Leiden UniversityDepartment of Internal Medicine (Nephrology), Leiden University Medical CenterDepartment of Cardiology, Leiden University Medical CenterDepartment of Human Genetics, University Hospitals LeuvenEinthoven Laboratory of Experimental Vascular Medicine, Leiden University Medical CenterDepartment of Computer Engineering, Antalya International UniversityDepartment of Pathology, CARIM, Academic University Hospital MaastrichtDepartment of Molecular, Center for Molecular Biology of RNA, Cell and Developmental Biology, University of CaliforniaEinthoven Laboratory of Experimental Vascular Medicine, Leiden University Medical CenterEinthoven Laboratory of Experimental Vascular Medicine, Leiden University Medical CenterPost-transcriptional control of RNA is important in health and disease. Here, the authors show that the RNA-binding protein Quaking guides pre-mRNA splicing and transcript abundance during monocyte to macrophage differentiation, and that Quaking depletion impairs pro-atherogenic foam cell formation.https://doi.org/10.1038/ncomms10846 |
| spellingShingle | Ruben G. de Bruin Lily Shiue Jurriën Prins Hetty C. de Boer Anjana Singh W. Samuel Fagg Janine M. van Gils Jacques M. G. J. Duijs Sol Katzman Adriaan O. Kraaijeveld Stefan Böhringer Wai Y. Leung Szymon M. Kielbasa John P. Donahue Patrick H.J. van der Zande Rick Sijbom Carla M. A. van Alem Ilze Bot Cees van Kooten J. Wouter Jukema Hilde Van Esch Ton J. Rabelink Hilal Kazan Erik A. L. Biessen Manuel Ares Jr. Anton Jan van Zonneveld Eric P. van der Veer Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression Nature Communications |
| title | Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression |
| title_full | Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression |
| title_fullStr | Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression |
| title_full_unstemmed | Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression |
| title_short | Quaking promotes monocyte differentiation into pro-atherogenic macrophages by controlling pre-mRNA splicing and gene expression |
| title_sort | quaking promotes monocyte differentiation into pro atherogenic macrophages by controlling pre mrna splicing and gene expression |
| url | https://doi.org/10.1038/ncomms10846 |
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